ID   W0I3Z5_9EURY            Unreviewed;       386 AA.
AC   W0I3Z5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Cystathionine gamma-lyase {ECO:0000313|EMBL:AHF80774.1};
GN   ORFNames=TES1_1396 {ECO:0000313|EMBL:AHF80774.1};
OS   Thermococcus paralvinellae.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=582419 {ECO:0000313|EMBL:AHF80774.1, ECO:0000313|Proteomes:UP000019027};
RN   [1] {ECO:0000313|EMBL:AHF80774.1, ECO:0000313|Proteomes:UP000019027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ES1 {ECO:0000313|EMBL:AHF80774.1,
RC   ECO:0000313|Proteomes:UP000019027};
RX   PubMed=25082851; DOI=10.1099/ijs.0.066100-0;
RA   Hensley S.A., Jung J.H., Park C.S., Holden J.F.;
RT   "Thermococcus paralvinellae sp. nov. and Thermococcus cleftensis sp. nov.
RT   of hyperthermophilic heterotrophs from deep-sea hydrothermal vents.";
RL   Int. J. Syst. Evol. Microbiol. 64:3655-3659(2014).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR   EMBL; CP006965; AHF80774.1; -; Genomic_DNA.
DR   RefSeq; WP_042681523.1; NZ_CP006965.1.
DR   AlphaFoldDB; W0I3Z5; -.
DR   STRING; 582419.TES1_1396; -.
DR   GeneID; 24907886; -.
DR   KEGG; ths:TES1_1396; -.
DR   HOGENOM; CLU_018986_2_0_2; -.
DR   OrthoDB; 43458at2157; -.
DR   Proteomes; UP000019027; Chromosome.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:AHF80774.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
SQ   SEQUENCE   386 AA;  43310 MW;  B3496FD58C7DA9E7 CRC64;
     MRGFSTKAIH VGEDPREMQH GDVVSPIHLT TTFAKKSVRE VEEGYVYSRS GNPTRDRLER
     KLAALENAKY GLAFSSGLAA ESTILLALLK KGDHVIAFDD LYGGTKRLFN QVMERFGIEF
     TYVDAREPEN VRSVIKENTK MIWLETPTNP LLKLADIKAI SEIAHERDLI VVVDNTFASP
     YFQNPLDLGA DIVLHSVTKY IGGHSDVVGG AVMVNDDEIY EKLKFHQNAV GAILSPFDSW
     LVMRGIKTLA VRMERHEKNA IRIAKYLEEH PLVERVYYPG LPSHPQHELA RRQMRGFGGM
     LSFELKGGLK EAIKFVESLE IFALAESLGG VESLIELPAL MTHASLPKEE REKVGIKDSL
     IRVSVGIEDV EDLIEDLERG FEAVRR
//