ID W0RF59_9BACT Unreviewed; 660 AA.
AC W0RF59;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Protein kinase {ECO:0000313|EMBL:AHG88975.1};
GN ORFNames=J421_1438 {ECO:0000313|EMBL:AHG88975.1};
OS Gemmatirosa kalamazoonensis.
OC Bacteria; Gemmatimonadota; Gemmatimonadetes; Gemmatimonadales;
OC Gemmatimonadaceae; Gemmatirosa.
OX NCBI_TaxID=861299 {ECO:0000313|EMBL:AHG88975.1, ECO:0000313|Proteomes:UP000019151};
RN [1] {ECO:0000313|EMBL:AHG88975.1, ECO:0000313|Proteomes:UP000019151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBS708 {ECO:0000313|EMBL:AHG88975.1,
RC ECO:0000313|Proteomes:UP000019151};
RX PubMed=24699952;
RA Debruyn J.M., Radosevich M., Wommack K.E., Polson S.W., Hauser L.J.,
RA Fawaz M.N., Korlach J., Tsai Y.C.;
RT "Genome Sequence and Methylome of Soil Bacterium Gemmatirosa
RT kalamazoonensis KBS708T, a Member of the Rarely Cultivated Gemmatimonadetes
RT Phylum.";
RL Genome Announc. 2:e00226-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CP007128; AHG88975.1; -; Genomic_DNA.
DR AlphaFoldDB; W0RF59; -.
DR STRING; 861299.J421_1438; -.
DR KEGG; gba:J421_1438; -.
DR PATRIC; fig|861299.3.peg.1461; -.
DR eggNOG; COG0515; Bacteria.
DR HOGENOM; CLU_391702_0_0_0; -.
DR InParanoid; W0RF59; -.
DR Proteomes; UP000019151; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR45832:SF24; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45832; SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:AHG88975.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000019151};
KW Transferase {ECO:0000313|EMBL:AHG88975.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 249..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 271..335
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 387..657
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 416
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 660 AA; 68167 MW; 36E85537C08383AE CRC64;
MRRADERAAR RRLEQDAEFV AHLLAGRERS LAGGARVFAQ GPYFRGLVAS QRPLHDELLD
QAMEAEDLLD ASWVFITDAR GRLLAKSDEP GAAGTDMGGV ALIAGALRGQ VMSGFGVSRD
SLLFQVIAMP IAVPNGTPVG VLVATNVIGE EVVRDVRATT GSDVLFYALG VDGRPHIAAS
SVARTTALDS ALGALSAGRR PGGGLLRVGA EDFHVQGARA TTAGGEAVGG WTVLRAHGAE
ASEVAGMRAT VAAVAVVGLA LALLAAWLAA RQVTRPIRAL ATLAHRAVEG DYDPTRDGVE
AVVGAADLDG EASDEIAALG AAFRAMIAEL RDREALTALG ARVPNEPAAA SAAVAAPTDA
RGASAVSGVR VLRLASPARP ARLAERYELQ AVVGAGGTGI VYKALDDALG EIVAVKMLRP
ELLAADPLAR ERLTHEIRLA RRISHRHVVR IHDIAENDGV PFLTMEFVDG PSLDALLHAR
GALEPRAVLA VAKQLVRALD VAHTQGVVHG DLKPANLLVA PGGVVKVTDF GVARLVRGPV
GPDAARIAGA VVGTPEYMAP ELLLGSAPDV RADIYAAGVV LHECLTGETP FNADTPVAFF
AHKLDETPAR GTPIPQGPTL AAPRGIAAAL GALVAQMTAA DPAGRPASAR AVYAMLLRIG
//
