ID W0SLP3_HASV8 Unreviewed; 497 AA.
AC W0SLP3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE RecName: Full=Non-structural polyprotein 1AB {ECO:0000256|ARBA:ARBA00019743};
DE Flags: Fragment;
GN Name=RdRp {ECO:0000313|EMBL:BAO31551.1};
OS Human astrovirus-8 (HAstV-8).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Mamastrovirus; Mamastrovirus 1.
OX NCBI_TaxID=43358 {ECO:0000313|EMBL:BAO31551.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:BAO31551.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IDH1300 {ECO:0000313|EMBL:BAO31551.1};
RA Pativada M.S., Krishnan T.;
RT "Molecular characterization of ORF1b of human astrovirus detected in
RT Kolkata, India.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Contains the viral protease participating in the cleavage of
CC the polyprotein into functional products. It contains also the
CC activities necessary for replication of genomic RNA, as well as
CC transcription of subgenomic mRNA. {ECO:0000256|ARBA:ARBA00029407}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
CC -!- SIMILARITY: Belongs to the astroviridae polyprotein 1AB family.
CC {ECO:0000256|ARBA:ARBA00005873}.
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DR EMBL; AB740319; BAO31551.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 248..374
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAO31551.1"
FT NON_TER 497
FT /evidence="ECO:0000313|EMBL:BAO31551.1"
SQ SEQUENCE 497 AA; 58154 MW; 94310C5F6994685B CRC64;
RAQTYHSLDA WKSLLVPPRE RRCVPANFPL LGHLPINRPI FDDKKPKDDL LGLLPEPTWH
AFEEYGPTTW GPQAFIKSFD KFFYAEPIDF FSEYPQLCAF ADWATYREFR YLEDTRVIHI
TATEKNNNST PVGPKMNYFD TEEDYLEAHG WAPYIREFTR VFKGDKPEVL WYLFLKKEII
KEEKMRNSDI RQIVCADPIY TRIGACLEAH QNALMKQHTD TSVGQCGWSP MEGGFKKTMQ
RLVNKGNKHF IEFDWTRYDG TIPPALFKHI KEIRWNFINK DQREKYRHVH EWYVDNLLNR
HVLLPSGEVT LQTRGNPSGQ FSTTMDNNMV NFWLQAFEFA YFNGPDKDLW KTYDTVVYGD
DRLSTTPSVP DNYEERVITM YRDIFGMWVK PGKVICRDSI VGLSFCGFTV NENLEPVPTS
PEKLMASLLK PYKILPDLES LHGKLLCYQL LAAFMAEDHP FKVYVEHCLS RTAKQLRDSG
LPARLTEEQL HRIWRGG
//
