ID   W0V0A5_9BURK            Unreviewed;       517 AA.
AC   W0V0A5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase PaaC {ECO:0000313|EMBL:CDG81301.1};
DE            EC=1.1.1.- {ECO:0000313|EMBL:CDG81301.1};
GN   Name=paaC {ECO:0000313|EMBL:CDG81301.1};
GN   ORFNames=GJA_642 {ECO:0000313|EMBL:CDG81301.1};
OS   Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Janthinobacterium.
OX   NCBI_TaxID=1349767 {ECO:0000313|EMBL:CDG81301.1, ECO:0000313|Proteomes:UP000027604};
RN   [1] {ECO:0000313|EMBL:CDG81301.1, ECO:0000313|Proteomes:UP000027604}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 102515 / DSM 9628 {ECO:0000313|Proteomes:UP000027604};
RX   PubMed=25883287; DOI=10.1128/genomeA.00277-15;
RA   Graupner K., Lackner G., Hertweck C.;
RT   "Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium
RT   agaricidamnosum.";
RL   Genome Announc. 3:e00277-e00277(2015).
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; HG322949; CDG81301.1; -; Genomic_DNA.
DR   RefSeq; WP_038488658.1; NZ_HG322949.1.
DR   AlphaFoldDB; W0V0A5; -.
DR   STRING; 1349767.GJA_642; -.
DR   KEGG; jag:GJA_642; -.
DR   PATRIC; fig|1349767.4.peg.2355; -.
DR   eggNOG; COG1250; Bacteria.
DR   HOGENOM; CLU_009834_2_2_4; -.
DR   OrthoDB; 5287258at2; -.
DR   Proteomes; UP000027604; Chromosome I.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:0010124; P:phenylacetate catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR011967; 3-OHacyl-CoA_DH_PaaH.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR041040; 3HCDH_RFF.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR02279; PaaC-3OHAcCoADH; 1.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF18321; 3HCDH_RFF; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:CDG81301.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027604}.
FT   DOMAIN          10..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          190..287
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          359..428
FT                   /note="3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-
FT                   fold"
FT                   /evidence="ECO:0000259|Pfam:PF18321"
FT   DOMAIN          429..512
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   517 AA;  54375 MW;  3AC7722BE2BD35D2 CRC64;
     MAALTQDSIV AVVGSGAMGA GIAQVAAASG YRVKLYDSRP QAVSKALAGI GKMFVKLAEK
     GRMTAGEAAA ASARLQAASS LDDLADAGLV VEAIVEHLEA KRGLFAQLEQ VVGDHCILAT
     NTSSLSVTAI AAGLRLPQRL VGMHFFNPVP LMALVEVVSG LATDAQAAST VFDTAAAWGK
     SPVHATSTPG FIVNRVARPF YAEGLRLLNE RAGDAVTIDT LMREAGGFRM GPFELMDLIG
     HDVNFSVTQS VFDAYFGDPR FTPSVLQQEL VNAGFLGRKT GRGFYAYGEQ AVQPLAQAEA
     PRPQPEFVAR SGAVGSHGAV IDALGQRLVQ AGITVSQRGM PEGHQDHEAP ALHCHGAAIY
     LSDGRSATQR ARDNRHPDTV LFDLVFDFAS AKRIAVTCAD QCSPAAYDAA VGLFQAAGFI
     VSRLDDVPGL AVMRTVAMLA NEAADAVNQG VCSVAAVDLA MRKGVNYPRG PLAWADDIGL
     GQVVAVLDNL ARAYGEDRYR ISPLLRRKLA HGVTFHA
//