ID W1DNU9_KLEPN Unreviewed; 323 AA.
AC W1DNU9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
OS Klebsiella pneumoniae IS43.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1432552 {ECO:0000313|EMBL:CDL11078.1, ECO:0000313|Proteomes:UP000019183};
RN [1] {ECO:0000313|EMBL:CDL11078.1, ECO:0000313|Proteomes:UP000019183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IS43 {ECO:0000313|EMBL:CDL11078.1,
RC ECO:0000313|Proteomes:UP000019183};
RA Barisic I., Mitteregger D., Hirschl A.M., Noehammer C., Wiesinger-Mayr H.;
RT "Antibiotic resistance diversity of beta-lactamase producers in the General
RT Hospital Vienna.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 GTP = 3',3'-c-di-GMP + 2 diphosphate; Xref=Rhea:RHEA:24898,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58805; EC=2.7.7.65;
CC Evidence={ECO:0000256|ARBA:ARBA00034247};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; 3',5'-cyclic di-GMP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004665}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL11078.1}.
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DR EMBL; CBWK010000603; CDL11078.1; -; Genomic_DNA.
DR AlphaFoldDB; W1DNU9; -.
DR SMR; W1DNU9; -.
DR eggNOG; COG2199; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR Proteomes; UP000019183; Unassembled WGS sequence.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
FT DOMAIN 194..323
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 323 AA; 36291 MW; E5158B34E4D2D455 CRC64;
MKLAGLHPDE QRRLQSLRSS GLLNSGKEER FDRLTRLARS LYNLPVASIS LVGEDLLHIK
SCAGLDVDTV PRDISFCAHT ILQTDPLIVN DMQQDERFHD NPLVIEAPFI RFYAGYPVQL
PDGATVGSFC LMDHQPRSFS AHEMQILSDL AAIVEDEFKV LDAATSDELT GLFNRRGFLT
LAEYALLTAQ RRHEPVSLAF VDLDRFKHIN DTWGHEEGDR ALIAIADLMK AAFRESDILA
RQGGDEFIIL FANTSRHDAA TAMETLSHNV ARFNQQAANP WQLAFSWGCV EYDPASHPSL
NALVATADRL MYQAKQKQGR ERR
//
