ID W1PI18_AMBTC Unreviewed; 1462 AA.
AC W1PI18;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=ceramidase {ECO:0000256|ARBA:ARBA00011891};
DE EC=3.5.1.23 {ECO:0000256|ARBA:ARBA00011891};
GN ORFNames=AMTR_s00029p00196710 {ECO:0000313|EMBL:ERN09637.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN09637.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- SIMILARITY: Belongs to the neutral ceramidase family.
CC {ECO:0000256|ARBA:ARBA00009835}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI392980; ERN09637.1; -; Genomic_DNA.
DR STRING; 13333.W1PI18; -.
DR EnsemblPlants; ERN09637; ERN09637; AMTR_s00029p00196710.
DR Gramene; ERN09637; ERN09637; AMTR_s00029p00196710.
DR eggNOG; KOG2232; Eukaryota.
DR eggNOG; KOG4197; Eukaryota.
DR HOGENOM; CLU_250705_0_0_1; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0102121; F:ceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0017040; F:N-acylsphingosine amidohydrolase activity; IBA:GO_Central.
DR GO; GO:0046514; P:ceramide catabolic process; IBA:GO_Central.
DR GO; GO:0042759; P:long-chain fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.60.40.2300; Neutral/alkaline non-lysosomal ceramidase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR InterPro; IPR006823; Ceramidase_alk.
DR InterPro; IPR038445; NCDase_C_sf.
DR InterPro; IPR031331; NEUT/ALK_ceramidase_C.
DR InterPro; IPR031329; NEUT/ALK_ceramidase_N.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00756; PPR; 6.
DR PANTHER; PTHR12670; CERAMIDASE; 1.
DR PANTHER; PTHR12670:SF1; NEUTRAL CERAMIDASE; 1.
DR Pfam; PF04734; Ceramidase_alk; 1.
DR Pfam; PF17048; Ceramidse_alk_C; 1.
DR Pfam; PF01535; PPR; 4.
DR Pfam; PF13041; PPR_2; 5.
DR PROSITE; PS51375; PPR; 7.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 112..146
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 182..212
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 213..247
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 312..346
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 413..447
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 516..550
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 617..647
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 713..1294
FT /note="Neutral/alkaline non-lysosomal ceramidase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF04734"
FT DOMAIN 1296..1461
FT /note="Neutral/alkaline non-lysosomal ceramidase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17048"
SQ SEQUENCE 1462 AA; 162321 MW; 38A5A00A81441E36 CRC64;
MLMTLYPRYF GTNPLPMHTY LCIRHGFLRR FSFPATVKIA IDKPVSCSEQ YYYTNLLSSC
KNLSSLKQIH GRLIALGLES DHSLEAKLLN LYSVYHGSVG GRLIFDFSKT PTVILWNSMI
KVYNKSNLYR EALVLYTDML KQAIEPDNYT FPFVLKACTG SLCLEMGFSL HGEVVKRGFG
LDGYICTGLI DMYCKFGYTE FAREVFNKMS ERDVVAWNAM ISGYSQVGDP KEALKVFREM
QMVGIEANSV SLLNLFPSVC WLSSLVLCKC LHCFAIKREF ELSVFNGLID LYAKCGNVEA
SRRIFDRLLK RDDVSWGSLI SAYSQNGYSV EALEIFGVLK RDKVRLNQVQ IVGALLAATD
LRDIEKGKEI HDYLIQRGTS LDIEVSTTLI TMYAKCGNLN LAKELFNGIE NGDLVAWSAM
ISALAHGEHP NEALQFFREM QNVNLKPNRV TIVSVLPSCA EISALKLGKS IHGYVMKVDM
GMGLDVSIGT ALVAMYVKCG CFSHAKLWFH EMPCKDVVTW NAMVNGYAQM GHAHKAMETF
RHMQSVGLKL DSSTLVGLLP SCALLKAINN GNCIHGHAIK LGFESDLHVM NATIDMYAKC
GCIGHAEKLF ETEFVKDEIS WNTMIAGYAQ NGRPKDAVSI FCWMREKEEL QPNLVSIVNI
IPAYAQLAAL NEGKTIHSYI KNMLTMSSLR KNAHSVLLST AGIWDALIRD SPYLIGLGSY
DITGPAADVN MMGYANTEQV ASGVHFRLRA RSFIVADSGG NRVVFVNLDA CMASQLVTIK
VLERLKARYG NLYNVQNVAI SGIHTHAGPG GYLQYVVYLV TSLGFVRQSF DVIVDGIEKS
IIEAHENLRP GSIFVNKGDL LDAGINRSPS AYLNNPAEER KKYKYNVDKE MTLLKFVDAE
WGPVGTFNWF PTHGTSMSRT NSLISGDNKG AAARFMEDWY EQNQKRAQRM HSSLLGLSLN
QISEIPRRVS WMISDQNANH KELIELAGSF QSPGGRPVTK LLGVSQRIRN SLKMSGHPSF
VSAFCQSNVG DVSPNVLGAF CNDTGLPCDF NHSTCNGKNE LCYGRGPGYP DEFESTRIIG
ERQFRKAVDL FNTASEQLKG KVEYRHTYVD FSKLEVSLSG GNGKQEVAKT CPAAMGFAFA
AGTTDGPGAF DFKQGDDKGN PFWKLVRNVL KTPDKEQVDC QQPKPILLDT GEMKRPYDWA
PSILPIQILR IGQMVILCVP GEFTTMAGRR LRDAVKTALI NGGNGVFDGN MHVVIAGLTN
SYSQYVTTLE EYQIQRYEGA STLYGPHTLS AYIQEFNKLA TALTSGHPAS PGPQPPDLLN
KQISLLPPVV VDMTPPGTSF GDMDTDVPKN ASFKRGDKVV ASFWSACPRN DLLTEGSFAV
VEKLSETDNK TWVPSYDDDD FCLRFKWGRP SRFSTHSYAT LEWYIRQNAV PGVYRLTHYG
AAKRIFGSIH HFTGSSSAFV VV
//
