ID W1QD36_OGAPD Unreviewed; 1148 AA.
AC W1QD36;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=ADP-ribosylation factor GTPase-activating protein {ECO:0000256|RuleBase:RU369028};
GN ORFNames=HPODL_03260 {ECO:0000313|EMBL:ESW99369.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW99369.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW99369.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase-activating protein for the ADP ribosylation factor
CC family. {ECO:0000256|RuleBase:RU369028}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369028}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW99369.1}.
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DR EMBL; AEOI02000007; ESW99369.1; -; Genomic_DNA.
DR RefSeq; XP_013935041.1; XM_014079566.1.
DR AlphaFoldDB; W1QD36; -.
DR STRING; 871575.W1QD36; -.
DR GeneID; 25772700; -.
DR KEGG; opa:HPODL_03260; -.
DR eggNOG; ENOG502QU87; Eukaryota.
DR HOGENOM; CLU_001720_0_0_1; -.
DR OMA; TKVEWLW; -.
DR OrthoDB; 2027807at2759; -.
DR Proteomes; UP000008673; Chromosome IV.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13280; PH_SIP3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045258; ACAP1/2/3-like.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042067; Sip3_PH.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23180:SF160; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1; 1.
DR PANTHER; PTHR23180; CENTAURIN/ARF; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51778; VAST; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|RuleBase:RU369028};
KW Cytoplasm {ECO:0000256|RuleBase:RU369028};
KW GTPase activation {ECO:0000256|RuleBase:RU369028};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|RuleBase:RU369028};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Repeat {ECO:0000256|RuleBase:RU369028};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Zinc {ECO:0000256|RuleBase:RU369028};
KW Zinc-finger {ECO:0000256|RuleBase:RU369028}.
FT DOMAIN 312..413
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 733..895
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
SQ SEQUENCE 1148 AA; 131688 MW; 9782C65ECFB9F135 CRC64;
MASNGERKDP HLAPGVLGST DVAFHHSEDR VVKLIAVGLK EASTDSPSFR ASVNYMNSEI
RSYHLLIKKT IDYLKRFVAA CTVLQSVSSE FQTIFTSIGQ NSLVNRDIAK TCIERTSQDM
NEVLGFINGA LAFKKEPIQN LLNLDGDFAA YFELRHAFEG IQAKYDSYLD KFVAQPKTLD
PTTAREDAQQ LFELRKQYIH ISLSIWISIT KLKHKVSSVL VEVCDTLRNS SEQSRNLAEF
LALEESSKKI ERAKYFMDLQ ARSHKSLIKD LLSARRTSEE SVINICTPSN DLDSYIPATI
NMAHLTDTDV EQYEKHGWVF LKSKRINSKE IVWIKRWLFI KGDLFGFLSI STSGTYVEES
DKIGILLANV RYKPEEDRKF CFEIKTLQTE VTIQVETLGE LKSWLSVFHT VKNSALQRNS
TISMSRYEPM LDLFALEPVV EKDLELVNLP STKPENAQML LNKSLPSLKV DVDFSAPLVT
ELTNLACLSH LYLTSPKVPS AFTANVWGFV NWGLYYAIKN RNDTLEIATK MHSSTLNSIN
LRYPASYPIE LRQLDLQLRS LFESYIDTDE FVLVAFRAFW SANSKQELFC HLYVTESHIY
VYTTNCGLVS ISLFKLTNFL YVDSVQKASY DLLRFYTVSG VSTKMKLCLE PGNLVKDQVN
YLISLKKSSV RKPLEMIMDE LTKIKQVHSK PKPKGLSSVP LAVPQNSEGE KPIVTIASSA
DMDTNMKLNY NEDMHLIWIQ KYDLPAKALF HVLVGDQSFL LQSMLPFAQL SVDTGTQHTV
WRCDSQQKLT RIIWSPTMEL LSAEQRIESM LNNKYYNFTQ STPYLYLPFG SAGRLIIRFI
IFNTDSRSSK LLVYYKVMRN RNILEIFSSF FFRQVILFKI DDLHKHLLAA IQNLANENRK
IASAIKLYGP ITKFDADELT EEEVRFDKDI KHIKMEFLLN LVLQKLNLEF DKLLHVAAKL
LMNALFSTYK NFQLHWLLIL SLSTSLIFNV YLSGKSTHAY WIEHNTEKYV NSLVQKPTLM
KRMISISDVQ DFAHNTSVQL SYNASESQCF LEFRKQAGVG EISLPTESKV QSRLVEFGLQ
RNELLTELGI VNAAERAYLA SEWKRWVFAE HRNCELARTK YPQKYDEQLS RYCESAKAEM
DHISHVLL
//
