ID W1U2C3_CLOBU Unreviewed; 583 AA.
AC W1U2C3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=Q607_CBUC00215G0057 {ECO:0000313|EMBL:ETI87806.1};
OS Clostridium butyricum DORA_1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1403941 {ECO:0000313|EMBL:ETI87806.1, ECO:0000313|Proteomes:UP000018876};
RN [1] {ECO:0000313|EMBL:ETI87806.1, ECO:0000313|Proteomes:UP000018876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DORA_1 {ECO:0000313|Proteomes:UP000018876};
RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA Banfield J.F.;
RT "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT community with otherwise low bacterial novelty that shifts toward anaerobic
RT metabolism during the third week of life.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI87806.1}.
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DR EMBL; AZLX01000215; ETI87806.1; -; Genomic_DNA.
DR AlphaFoldDB; W1U2C3; -.
DR PATRIC; fig|1403941.3.peg.3224; -.
DR Proteomes; UP000018876; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 458..556
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
SQ SEQUENCE 583 AA; 68045 MW; 60A906D7E8108B50 CRC64;
MALDGIYLNS LMRSLEDTLL GSKIDKINQP EKDEIILTLR KDRKNIKLLI SSSPRFARIH
LTETVKENPI KAPMYLMVLR KYILGGRIIK VTQKDSDRIL IMEIENRDEL GFDSVYSLII
EIMGRHSNIT LVRNRDNKVM ESIKHITPDI NSYRVLYPGV NYVFPPKSEK LNPFTCSYDE
FNNYISSNSL IFDDKFYSAC FTGVSKLLSQ DLYFTLTEKI QSPTRTEIYN NFKDLMDNLD
KNLSFKIYTT KTGLIKDFYS LNLSFFEKDY NSISYDDPNE LMDDFYSKKD KQDRLQNKST
DLQKLIHTNI ERCNKKAKIL HETLKECEEK EELRIKGDLL TSFIYTIKKG DKECSLLNFY
NENEEEYITI SLDSNKTPSE NIQRYYKKYN KLKVSEEYAK MQLSKNEEEI EYLNSVLTNI
INVESYDEID EIKKELIETG YIRFNKNLKN GKKNKTSKPH HFVSSDNIDI YVGKNNLQND
YLSLKFANKN YLWLHAKDIP GSHVIVCDFN VPDTTLEEAA IIAGYYSKGK NSPKLSIDYT
KVKELKKPNG AKPGMVIYHT NKTVIINPNE FTKKFEKNNS NKQ
//
