ID W2E4W1_9BACL Unreviewed; 460 AA.
AC W2E4W1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Flagellar biosynthesis protein FlhF {ECO:0000256|ARBA:ARBA00014919};
DE AltName: Full=Flagella-associated GTP-binding protein {ECO:0000256|ARBA:ARBA00030866};
GN Name=flhF {ECO:0000313|EMBL:ETK26624.1};
GN ORFNames=ERIC1_1c00510 {ECO:0000313|EMBL:ETK26624.1};
OS Paenibacillus larvae subsp. larvae DSM 25719.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=697286 {ECO:0000313|EMBL:ETK26624.1, ECO:0000313|Proteomes:UP000018834};
RN [1] {ECO:0000313|EMBL:ETK26624.1, ECO:0000313|Proteomes:UP000018834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25719 {ECO:0000313|EMBL:ETK26624.1,
RC ECO:0000313|Proteomes:UP000018834};
RX PubMed=24599066;
RA Djukic M., Brzuszkiewicz E., Funfhaus A., Voss J., Gollnow K., Poppinga L.,
RA Liesegang H., Garcia-Gonzalez E., Genersch E., Daniel R.;
RT "How to Kill the Honey Bee Larva: Genomic Potential and Virulence
RT Mechanisms of Paenibacillus larvae.";
RL PLoS ONE 9:E90914-E90914(2014).
CC -!- FUNCTION: Necessary for flagellar biosynthesis. May be involved in
CC translocation of the flagellum. {ECO:0000256|ARBA:ARBA00025337}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK26624.1}.
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DR EMBL; ADFW01000001; ETK26624.1; -; Genomic_DNA.
DR RefSeq; WP_023484711.1; NZ_ADFW01000001.1.
DR AlphaFoldDB; W2E4W1; -.
DR PATRIC; fig|697286.3.peg.54; -.
DR OrthoDB; 9778554at2; -.
DR Proteomes; UP000018834; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd17873; FlhF; 1.
DR Gene3D; 1.20.120.1380; Flagellar FlhF biosynthesis protein, N domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR020006; FlhF.
DR InterPro; IPR047040; FlhF__GTPase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR NCBIfam; TIGR03499; FlhF; 1.
DR PANTHER; PTHR43134:SF3; FLAGELLAR BIOSYNTHESIS PROTEIN FLHF; 1.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00448; SRP54; 1.
DR SMART; SM00962; SRP54; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795};
KW Bacterial flagellum protein export {ECO:0000256|ARBA:ARBA00023225};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000313|EMBL:ETK26624.1};
KW Cilium {ECO:0000313|EMBL:ETK26624.1};
KW Flagellum {ECO:0000313|EMBL:ETK26624.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 264..455
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|SMART:SM00962"
FT REGION 60..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50530 MW; E92C9CBA1635183C CRC64;
MRVKRYVVDS MPDALQKIRT DLGKDAVIMN TKEIRSGGFL GFFSKKRIEV IAAIEQENTV
KTAKEPPVSR PKAKSAAVPA KSATAKKEQP AQPEPVKPVP AVPAATVPKA YKAAVAVSSP
HDQPAEAVKE VSQLSTAFLS EMKAFREEAA ETSDQAGEPE VPHSSREDVL LSEIQQMKAM
MAQMSAVGVQ PPPSRAEPFA GMERHLRNQG IDPKWIEELL NQADSAAAGA QTTWTPDELR
QSVASQLKDW FNRDGSPSPV SRTAKMIHFV GPTGVGKTTT IAKLAAEQVL KHHKKAGFIT
SDTYRISAVE QLRTYANILG VPLEVVFSPQ DLPRAFEALQ DVDVIFMDTA GRNFRKELAV
SELNALLQSC GETETYLVLS LTTKYEDIRV ITENFIKFGV DKVLFTKMDE TATYGTLVNL
KRDFQLPFSY LTDGQNVPDD ITLADEDKIV ELLLEGYSHG
//
