ID   W2EK91_9ACTN            Unreviewed;       549 AA.
AC   W2EK91;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Ribulokinase {ECO:0000256|RuleBase:RU003455};
DE            EC=2.7.1.16 {ECO:0000256|RuleBase:RU003455};
GN   ORFNames=MPTA5024_31680 {ECO:0000313|EMBL:ETK32079.1};
OS   Microbispora sp. ATCC PTA-5024.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Microbispora.
OX   NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK32079.1, ECO:0000313|Proteomes:UP000018869};
RN   [1] {ECO:0000313|EMBL:ETK32079.1, ECO:0000313|Proteomes:UP000018869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK32079.1,
RC   ECO:0000313|Proteomes:UP000018869};
RX   PubMed=24459268;
RA   Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA   Stegmann E., Weber T.;
RT   "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT   Producing the Lantibiotic NAI-107.";
RL   Genome Announc. 2:e01198-13(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:22072, ChEBI:CHEBI:15378, ChEBI:CHEBI:16880,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58226, ChEBI:CHEBI:456216;
CC         EC=2.7.1.16; Evidence={ECO:0000256|RuleBase:RU003455};
CC   -!- PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-
CC       ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route):
CC       step 2/3. {ECO:0000256|RuleBase:RU003455}.
CC   -!- SIMILARITY: Belongs to the ribulokinase family.
CC       {ECO:0000256|RuleBase:RU003455}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETK32079.1}.
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DR   EMBL; AWEV01000255; ETK32079.1; -; Genomic_DNA.
DR   RefSeq; WP_036330683.1; NZ_KI866525.1.
DR   AlphaFoldDB; W2EK91; -.
DR   STRING; 316330.MPTA5024_31680; -.
DR   PATRIC; fig|316330.3.peg.6108; -.
DR   HOGENOM; CLU_009281_9_1_11; -.
DR   OrthoDB; 9805576at2; -.
DR   UniPathway; UPA00145; UER00566.
DR   Proteomes; UP000018869; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0008741; F:ribulokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019569; P:L-arabinose catabolic process to xylulose 5-phosphate; IEA:UniProtKB-UniPathway.
DR   CDD; cd07781; FGGY_RBK; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; FGGY_C.
DR   InterPro; IPR018484; FGGY_N.
DR   InterPro; IPR005929; Ribulokinase.
DR   NCBIfam; TIGR01234; L-ribulokinase; 1.
DR   PANTHER; PTHR43435:SF4; FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43435; RIBULOKINASE; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   3: Inferred from homology;
KW   Arabinose catabolism {ECO:0000256|ARBA:ARBA00022935,
KW   ECO:0000256|RuleBase:RU003455};
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW   ECO:0000256|RuleBase:RU003455};
KW   Kinase {ECO:0000256|RuleBase:RU003455, ECO:0000313|EMBL:ETK32079.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW   Transferase {ECO:0000256|RuleBase:RU003455}.
FT   DOMAIN          8..277
FT                   /note="Carbohydrate kinase FGGY N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00370"
FT   DOMAIN          289..486
FT                   /note="Carbohydrate kinase FGGY C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02782"
SQ   SEQUENCE   549 AA;  58238 MW;  5C65E1B1D0475D56 CRC64;
     MNANSERYVV GVDFGTLSGR AVVVRVSDGA ELGAAVHEYA HGVIEDALPG SGVRLGPDWA
     LQSPQDWVDV LRHAVPKALA AAQVPAAQVV GIGTDFTACT ILPAAADGTP LSETLPDRPH
     AWPKLWKHHA AQRHADRINE LAAERGESWL ARYGGKISSE WAFAKGLQVL EEDPEVYERA
     DRWIEAADWI IWQLCGVETR NVCTAGYKAI YQDGGYPSDD FLAALNPAFA GFTGKLGREL
     APLGGLAGRL TAQAAEWTGL PEGVAVAVGN VDAHVTLAAA DAVRPGQMVA IMGTSTCHVM
     NSDHLAEVPG MCGVVRDGIV PGLWGYEAGQ SAVGDIFAWF VESSVPASYA ERAAELGLGL
     HEYLTQLAEA QPVGGHGLVA LDWQGGNRSV LVDHNLSGVI VGQTLATRPE DVYRALIEAT
     AFGARLIVET FEKAGVPVEE FVVAGGLLKN AFLMQVYSDV LRRPLSVIGS DQGPALGSAI
     HAAVAAGEYP GISEAAAAMG KREAAVYAPD PERADAYDRL YAEYRRLHDH FADGEVLHRL
     RAIRNGATA
//