ID W2ER81_9ACTN Unreviewed; 393 AA.
AC W2ER81;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Molecular chaperone GroES {ECO:0000313|EMBL:ETK34194.1};
GN ORFNames=MPTA5024_20815 {ECO:0000313|EMBL:ETK34194.1};
OS Microbispora sp. ATCC PTA-5024.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK34194.1, ECO:0000313|Proteomes:UP000018869};
RN [1] {ECO:0000313|EMBL:ETK34194.1, ECO:0000313|Proteomes:UP000018869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK34194.1,
RC ECO:0000313|Proteomes:UP000018869};
RX PubMed=24459268;
RA Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA Stegmann E., Weber T.;
RT "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT Producing the Lantibiotic NAI-107.";
RL Genome Announc. 2:e01198-13(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK34194.1}.
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DR EMBL; AWEV01000153; ETK34194.1; -; Genomic_DNA.
DR RefSeq; WP_036325661.1; NZ_KI866523.1.
DR AlphaFoldDB; W2ER81; -.
DR STRING; 316330.MPTA5024_20815; -.
DR PATRIC; fig|316330.3.peg.4015; -.
DR HOGENOM; CLU_026673_11_3_11; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000018869; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08283; FDH_like_1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..142
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 189..257
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 393 AA; 42392 MW; 9C16924C118124F0 CRC64;
MKAVTWHGKR DVRVEEVPDP AIKEPTDAII RVTTTAICGS DLHLYELLGP FIGEGDVLGH
EPMGIVEEVG AQVTHIAPGD RVVIPFNISC GHCYMCDRAL FAQCETTQVR EYDTGAALFG
YTKLYGEVPG GQAEYLRVPQ AHFGPIKVPE GPPDERFVYL SDVLPTSWQA VEWAEVPDGG
SVTVFGLGPI GQMSARVARY RGYRVIGVDV VPERLEMARR HGVEVIDGSQ VDDVPGAVRS
MTGGRGTDSV IDAVGMEAHG SAGGKLAQTM TSLLPDRAAA AMMTRVGVDR LAALQQAIET
VRRGGTISVS GVYGGMTDPL PMLQMFDKGV ALRMGQAHVK RWIDDLMPLV TDDADPLGVE
DLATHVLPLD EAPHGYEIFQ KKEDGAIKVL LRP
//
