ID W2FT43_PHYPR Unreviewed; 2292 AA.
AC W2FT43;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Pre-mRNA-splicing helicase BRR2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=L915_19792 {ECO:0000313|EMBL:ETK73250.1}, L916_19676
GN {ECO:0000313|EMBL:ETL26687.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETK73250.1};
RN [1] {ECO:0000313|EMBL:ETK73250.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ02B3 {ECO:0000313|EMBL:ETK73250.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ02B3.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETL26687.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ05E6 {ECO:0000313|EMBL:ETL26687.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ05E6.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI689360; ETK73250.1; -; Genomic_DNA.
DR EMBL; KI676163; ETL26687.1; -; Genomic_DNA.
DR EnsemblProtists; ETK73250; ETK73250; L915_19792.
DR EnsemblProtists; ETL26687; ETL26687; L916_19676.
DR VEuPathDB; FungiDB:PPTG_05693; -.
DR Proteomes; UP000053236; Unassembled WGS sequence.
DR Proteomes; UP000053864; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 556..742
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 753..992
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1437..1635
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..261
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2292 AA; 257785 MW; FD0890AC99E9B2F5 CRC64;
MAEEVARSRQ YAYQQNSNLV LQADSESRRR PDEPTGEVES LAGKITYRMG DRAQKATPQS
SRKRHGGDKD AESKHKKKKR RGDADDAGKG VLFTATGGLA AAKSNILKES SAFESAAYRP
KNPASQEAYE QILGVVAQQL GAQPGEILAG AAEEVLAIIK NDNYRDDEKH KEVQKLLKTI
PTHTFSQLVA AGKRITDFFP ESGEKKAGEE DGEDAAAVES DEEVDKEMGV AVVFDEEDEE
EESDLDEVRD EEEDDEEEEA TATGREAMKM KDGYDDEDDG DAKYRLDVHA IDAFWLQREL
SKFYKDAEIS AKLAEDVLNI LKEAGSDLSA CENRLVLLLD YDKFDFIKLL LENRAKVLYC
TRLKQAQNDE ERRSIEEEMV ADETLNDGEG RTILEQLRTT ASADSWMQDR IGAMETTSRA
EANKLRKLQQ KSGGQRAQAR GDESDDDVDM EDVSRDAVKK EGEGVPKKKP QHYVDVESLA
FQEGGHLMSN RECRLPEGTW RAQKKGYEEV HVPAVRTKIA AAEEKARIKI STLPKWAQGA
FKGMESLNRV QSKMFPAAFK TSENLLLCAP TGAGKTNVAM LTILHEVMKA RDPETGEIDL
NSFKIVYVAP MKALVQEVVL NLSARLSSAY GIQVRELSGD QNLSREQLFN TQIIVTTPEK
WDIITRKSGD DRTYTQLVRL VIIDEIHLLH DTRGPVLEAL VARTIRNVEA TQQMVRLVGL
SATLPNYEDV AAFLRVDPAQ GLFYFDSSYR PVPLQQQYIG IMEKKAVKRF ALMNEICYEK
VMEQAELDNQ VLIFVHSRKE TASTAQALRD LFVENDTLAR LIKPNSASSE VLLQEAEKIE
RNDDLKDLLP YGFGIHHAGM KRQDRTLVEN AFADGHLKVL VSTSTLAWGV NLPAHTVIIK
GTQIYNAEKG DWCELSPLDI LQMLGRAGRV QFDTQGEGII ITQHSQLTYY LSLMNQQLPV
ESQLMSRLAD NLNAEIVVGS VQNVAQAATW LGYTYLFIRM LRNPTLYGIS IVDRKADPTL
LQYRTDLVHS AATLLAKHNL IKYERRSGLF QVTALGRVAS HYYIAHDSIS TYNEYLKPHM
SDIEILRLFS LSNEFKYVIV RSEEKLELVK LLERVPVPVK ESLVSTAPGS VAAGSGSAKV
NVLLQAYISR LKLDGFALLA DMAHIHQSAA RIFRALFEIC LTRGWASLAE RMLSFCKMVD
KRMWLSHSPL RQFAPGISET ILKRIEKKDI SWEKYNDLEP ADLGQLINNP QYGKQLYKMI
HQFPKLELSA HVQPITRSML KVDLVVTPDF EFTRDVHGNA EGFWVFVEDV DGETILHHEW
LLIKRRFASQ ETYLSFTMPL FEPLAPLYYI KVISDKWIHC ESSLPVSFHK LILPQKNAPP
TELLDLQPLF VNNILLKLVG GKKKTAESVL KSLSNAREVP NPWRFKRFNP IQTQVLPRVL
ESESNLFIGS PPGSGKGVLA ELAIMKTLLS LGQPDPKSDE FGEHLIVYLT PKESSCHQKY
GDWNAKFGEE SFWRQNVVEL TGDSTADLRL LASANILIAT PTQWDVLSRR WKQRKRIQNV
SLLLLDEAHF VGGGEYGPTI EVVMSRMRFI AADMEKKKKA AGERGGRMRI LAMSNSIANA
RDVGEWLGAS ASEGIFNFHP NVRPQPLEIR VQGFEINDFS SRMLAMAKPL YNTIANQAEK
KPAVVFVPSA KQAQLSAIDL ITFALAENDP QKFVSHSAKD KVELPLDDAA LLHTLENGVG
YCTDTMSSRN REYVLNRFAT GKLQVLIVPQ SMAWELQSAQ TSAFMVVIMG TQFYDGREHR
YVDYQLADVF QMTKFANHAA SPAVKCVLFC HASKKKFYAK FLYDPLPVES QLEHFLSDHI
NAEIVTKTIE SKQDAVDYLT WTFMYRRFMK NPNYYNLQGA TNVHLSDHLS ELVETTVNAL
EESRCIQVVE EEEDEENEGE ERLVPLNLGM IAAYYYIKYT TIELFACSLK ADSKVRALLT
ILSSATEFSD LPSRYGEDKK LEGLAKHLKF PVAAGGDYGQ PHVKTNVLLQ VHFSKQHDRL
SPALRQDLDY ILRHAVRLLH AMVDVISSNG WLKPALAAMD LAQMVVQAQW SSESPLLQIP
FFTKDMLKKL GEMELDEEVE TPVDILSMED DARSKLLPLD TQKMSAVAKF CNAFPDVTVQ
TKVQQDGKDL PQGSAVSVKV QLEREGADED EEEDEDKELG LVNACHYPVK KAENWWVVLG
DAKKNTLLSI KRVPFASARA NVTLQFAAPD ELGAHTFQLY VICDGYAGCD LENEVKITVV
QGEDTDEEED EE
//
