ID W2GJH8_PHYPR Unreviewed; 3293 AA.
AC W2GJH8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Myosin-I heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=L915_12198 {ECO:0000313|EMBL:ETK82410.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETK82410.1};
RN [1] {ECO:0000313|EMBL:ETK82410.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ02B3 {ECO:0000313|EMBL:ETK82410.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ02B3.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KI687215; ETK82410.1; -; Genomic_DNA.
DR EnsemblProtists; ETK82410; ETK82410; L915_12198.
DR VEuPathDB; FungiDB:PPTG_13150; -.
DR Proteomes; UP000053236; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17781; CBS_pair_MUG70_1; 3.
DR CDD; cd17782; CBS_pair_MUG70_2; 2.
DR CDD; cd14890; MYSc_Myo29; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 10.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13140:SF856; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF00571; CBS; 14.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00564; PB1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00116; CBS; 18.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 10.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51371; CBS; 15.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51745; PB1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3268..3290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..764
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1264..1322
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1331..1391
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1422..1485
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1494..1552
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1603..1662
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1670..1727
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1840..1901
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1946..2004
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2013..2070
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2304..2362
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2371..2427
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2572..2631
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2702..2762
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2770..2826
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2868..2927
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 3095..3181
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..666
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1048..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2670..2696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3225..3258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 902..962
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1000..1046
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1096
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 129..136
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 3293 AA; 362042 MW; 318C03124B7B77FB CRC64;
MERRGGGTRK ERLLRAKMKK KMQDSDSSPN GNTFEDILHM PDLSEQSLLE NLRKRYEHEL
IYTYVGPIVI AINPYKQLDV YSERHMTEYY GKAMGALPPH VFALADHAYT QLIQGGALDP
ANQSIIISGE SGSGKTETTK IIMQYLARAT SYRKGPEGEG PPPAPLEGMS GALGKLEERV
LESNPLLESF GNAKTLRNDN SSRFGKFIEI QFNHHGKIVG AQILNFLLEK TRIVSQSLGE
RNYHIFYQLL AGADNALRER LQLQTPHDYE YLRKSECFNI HSCDDAKEFA TTKRCLETIG
ITEDRQEMVF ELLAAVLHLG NLQFAMENDT CVTVGDISAN GMKLVANLLK VSEDALSKAL
LTRQLYVGGK VIVQQQNSEQ VRDKRDALAK GIYSSLFLWL VSELNRTISR HQDKWGFIGV
LDIYGFEKFE WNTFEQLCIN YANEKLQRHF NQHMLEVEQN DYAKEGIDWK HIDFEDNQEC
LDLIESKVNG KPGIFISLDD NWRLKGEEAN KKFVSNLHNS FGRTSSGHSS GKNKFYVHPK
MDADLHFGIK HYAGEVIYDA SGFNDKNNET LNDDMKELIR QSKSDWLRGI FDLNMQSIEA
IPGNKPQQQH SISRRPNEMK KGMQGNKSRN IREVSVSAQF RHQLHELMNK ISLANPRYVR
CIKPNEFKRP SELNDADCAR QLKYSGMMEA IQIRQRGFAL REDHDVFFYD YQSLAPDAEN
IKELVEEISS MLGAGKEEWQ LGKTKVFLKR AMAFKLRKLE MLRCKSAARA IQKWVRNMAR
AEAAVKIQTK ARQFVAKRRL QRLRRSAYRV MYILRMRVAV SKYRRMRDEY RMQNEKAVAV
QKIARGYLVR KRDLLHPFGD MGPKELDAKI AEMEKAIEDA AVSKQFELCA NLQLELEKIV
EARKKVRTAK EIDAEIKKLN EDMEAAALSK QFGLCAELQK QLEVLQEARK HVKEDLNELE
PEELDERIHA MEATIAEAMA ARDFGKCSDL QVSLDALVSA RKKKQTPEEL DAEIEKLNEE
LDNLMKKKQF DKCAQLQKDI DVLKKKRAKF PAAVKAPTPP PSPKPEPPAE PTPPPSPKKE
TNPPEEPEPQ PATPAPPSNM DRSGILPSRD AATAAPNSSP AALPGEKRPA PEVQAAPIPA
PAPTPAPLAS PVAVSSTQSF EEHPTAPVNE YVAPQEIPTA PQMPRRPPAI YNGPSPSVRR
GESNTMTPMM PIKQPTFERR ARSGSNSSAT SGHSFARSHS SMMSTSSKTK KSSNADPSRT
VARLRPAKAI TVNQEATVLE AARLMKSHRS AAVLVTNWEG ALTGIFSDTD AARRVISKGM
DPARVTIGSV MTPNPSCVSL EDSAVDAMDI MLSGKFRHLP VVSAHSGNIV GVLNVAKCLH
DAIRRVENMS TSLQQELGAS SNNAMLRGML EKMLSPSLLD VLSKPGEVMP PLVYGNMTVF
EATTYMAETR RPALVVSSNP EAPDLIGIFT PKDVLLRVVA EDLDVNTTPV SDVMTPNPES
AAPETSVLDA FHIMHDGKFL NLPVVAPDSG EIMGVADVLS ISLASFGESR DIGKFFNAAF
DYHDDETNSI VSGRSTSNLS VASKARQQKD RDKGVNVRPV SSLRPLPAIT IDEVASVFEA
SLLMKQKRTD ALLVVDEAGG LNGILTDTDI CRRVLALNLN PEEVPVCNVM TRDIKYVSPN
DSAIDALLSM QEGHFRHLPV VDGGSIAGVL NIGKCIYDVS KRLEHAMQST DQLKASLEKS
GKSSTLQQLL APMLEKLSTP TLGSILDNET QNGSTPAPRL PKSSLVSDVA KAMASTKKAA
LIVDDINFDK LVGVFSPNEL VLNVIAKGLK ASATYVEEVM LNDPEIATPS TSVLDGLHIM
HDSRILNLPV LKDDSNELVG MVDVLDLSYG TIDAIYGENR EQMQEFWNTT LQLDQPSLPS
EAGDRERTTL LSRAEREEKS RTVAKLRPTK VLTVVETTTV AELSRIMGRN KMDCVLVVSE
EGMLAGIITD TDLTRRVVSE NRPLDSTLVG DVMTRNPVFV SMDDPAIDAL ICMLEGKFRH
LPVVERNGPV VGILNIAKCL YDAIRKMEKS EQSSAALRHT LEKEMKSRVN GGARVGGVSQ
LLGSMVNKMF SPDIKTVIEE EGVEPPRVQR YTSVFEVSKQ MAVTKKGALV VNNRGQFCGI
FTPKEMLEKV LARGLPVHTT PVCEVMLEKD VTINGATSVI DAMHTMHDHK TLYLAVMQTE
TSQQPIGLID VLSLSYGSFA KGKPSEWKSF WNASFEATDD DDVSSQHSFR SGFSHNLAPS
SSGLSQKGRQ ANLATGNVRP VSKLRPSKAI TISETFSVAD AAKEMSTAQT DAALVIGRDG
GLLGILTDTD VTRRVVALGN DPFYVSVLDA MTPDPKFVDE RDSAMDAMFM MLEGKFRHLP
VVDETGMVAG MLRIQKCLYD AITRIEKVQQ SSSGSLRQRL EKQLQATGIG TGQGALKQLV
APMVEKLLSP TVDQILEDET LPPLVSEHDT VMEVARQMAA SRKAALIVED PNGDNSSSIS
GGHRSSISGG GYDIGTSALT RKVLGVFTPK DLLLRVTGAG LDAAETTVGQ VMTPDPETAP
PSTRLVDALH IMYEHNFLHL PVVNDETATI VGMLDVLSLC YGTFASGAAA ESGKPVDEDS
DWRAFWDVSL ALGHDEDDFS ELASVTGSRV SRRRPGKYTE SHHSSMMDHI PEPEGAMRPV
SMLRPQEVTR INEFITVAEA ARRMRQARVE AVVVTTEEGE LRGILTDTDI TRRVLAEEID
PESCSVASVM TTKPMCVYME DQAIEAITKM LEGRFKHLPV LGSDGTPQGM LDISKCLYDA
ITCLEKVQQS TEAAASEFSR DLGTGSNLQR LLGPMMEKMV RPTVGDALDG EIMPPVVNIH
TTAARAAKLM ANTKKAAIVL GDEQELCGMV TTKDLLRKLV AKGLYAETTT VEEVMTMDPD
LMGPDMSIVD GLRSLHDAGQ LFMPVLADDG EILGMADVIC LSYGQFQTTS GGTSNGDWRQ
FWQTAMNLQE EVAGGAYGGM NDDARSVGTI EEFERDEYNA GGSVSTPTAS AVGLNGAGRY
SNSLGAYAEL GESVSVVSGA NTATTSVLMQ KNMDDNTFVF KVSDGAQGHF HRIMCRFNSM
GPLLEQIRFK MGMDDNEALR LKYEDDEGDL ALLTSDESLV EAVHMAQRAG WKRLVLVVDV
VKRPQHDGNG SVVSMASSAA SATPSAAPSG SNAVGPKPRN RLLTKVDEMS SSSESSDESS
DEEIVRKKSK KSRRKRERVQ GFSLNNQAGL IAGGAATLVV GLGAMALMLL RRK
//
