ID W2GXX7_PHYPR Unreviewed; 2446 AA.
AC W2GXX7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=L915_07870 {ECO:0000313|EMBL:ETK87734.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETK87734.1};
RN [1] {ECO:0000313|EMBL:ETK87734.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ02B3 {ECO:0000313|EMBL:ETK87734.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ02B3.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI686074; ETK87734.1; -; Genomic_DNA.
DR EnsemblProtists; ETK87734; ETK87734; L915_07870.
DR VEuPathDB; FungiDB:PPTG_11257; -.
DR Proteomes; UP000053236; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 4.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 4.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF00520; Ion_trans; 2.
DR SMART; SM00100; cNMP; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 4.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 275..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1297..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1370..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1431..1451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1873..1890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2015..2035
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2060..2077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2089..2120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 377..475
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1103..1175
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1620..1751
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2240..2330
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2365..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2446 AA; 277523 MW; 044556D88BF8D064 CRC64;
MRVMPAPAAS RRSSRSRRRS SVARTPSRLT TLLLRQRARA GSSERLLNEN HNAFDPSSRF
IRICQQLRLA AILFELVAIP FLPAFHPETS RSQLIGIYAC ELLFCADIYV QLNTGYYENG
NVLRDAKKAR RKYLSSPAFA ADLLALIPLS LLLPTSTTGS RSIALLEMHK LVRVWRLPAL
ASNLDDLYAR HFESLKLTKM LGFTLLLTHF VACGRFSFGY SHPAPGEEPN HWLPHAPHEG
HHSARRQYLM SLFWAFGLLT GGFEGELPHH NAEFAFTIVV GLCGFTLFTS LCATFFLLSK
CESGDAELAE ARVHQFQHIL AFHRVPVQLQ AQAVDYLQRY HTQAEANDRE AARRLCPSIS
VDIQVELLEA TVALVPVFAS CDTQFIRAVA RLLELIALPA RTPLFRAGDH GDAMYIVHTG
VLHTVVGGVK VRELRKGNFV GEVAVFARQP RTATVITATY CTLYRLSRVH ADKLLEGYPQ
YAQVINQTVA EMLQKSSTTA VEPIGNDSDN LQVDNSRSER EPKTRGMLSF AQLVRIKQLL
HTRVLARKTR NQVIDEAAKQ KVWAAPPSPS KETREESKPA VEHLHSPPLE VRGASIAPET
STAPRHSLSL LQSFHSTSFR SDSALSSRTR SKNESHSKVS PMSPQGTSSI TVLPTEQSTR
RNSRRISFLA GGLNRLTTLR DNFFHDNAVR PSDAIQGFYD RIPHLAVSSK PRYHWWHRFL
MERGLDAESN WRMVWIALVT AVNCYNWVLV PLLLSFSALD GLWTRWYLIM LNLIADFVLW
IDIYINLHLS FTVNSEKILE PTRTAERYVY SGKLFVDLCC AWPYWIFIPR KFTHPVVRVP
RLISGYRMRG FIGEAAAYFH LSSKHKLLLL GVLFLMLYHI VACLYFSTTY IDGYSTGENQ
WLPSEDVYLQ RLNATHFQTI SGIILAADSD HVQAIRAEQY FRSLYYAANV LAAVGRMVEP
SSDTEYGAAL IFMLSGFFIT AIVVDHVQKG FTASALEEKE FFAARARFQR FLKRQNAPLS
IHVRVNSFLD FWWSAHRGAI IDELLEDLPA AIKRDVVHSI CTPAMDSLEI LCSSATVPNN
AEADGTTTKK ESSALLEQID EIFLDNLKFV LYGQGEIIYR RGDYAAGLFF LLEGKVSVVL
DGEAPRHVPL GGFFGTAALQ SSARDRRETR RRSNVDVFAG IGYAERVTAV SGCIVVYILR
EHLQAMQNIL PSLPENLRKL EQRFHDARVT RSADLRALQP RVPLGAIGLN NPTMRGALRR
KQMTGLVQVL AKNLDWWQRG TAIDPDWPFV GIWEATMLMA STVQGTLVVF YICFGAIESS
NGRAFADAVT ITLELLFVLD VYLHFRLGFY EYGNKVMDLA VIQKRYLRSM HFAIDMAALV
PLFIVNWSLP SRKLEILNVN KMLRYLKGSS QFRTLETKYV KLTTELRLLK LVYYSFLASH
MFGCIWFDFA AHKSGVHIVM SGSTDTSTPS FGASVWGPYN SLESAARGLQ YLASIFWAYG
LMSNSSQGEL PKTVGECLFS VITMTTGFFL FAYVVGHISD VIELQDSENR HFVAKLSSLR
QLLRHFDLPP RVEEKFKKYF FFKRFHSITQ EHVLERVLPP SLVVDMRMFQ LQPMIVKVAF
LVGMEDSVTR MLVSLFTQVL YVKDEFICHF GEEGSEMFFI YTGVLDIYIP FLSPSTHPVF
FPTSATGGRV SLSGLRKVNE ITAGSYFGEA ALFTNTPRNA YVRANTSCIL YKLSRHSLEL
VFLRYPEWQQ KVLRIVKIQQ QQQRLQRLAY EAQAPDAGGG GRRRGAKRTE SSMDLVNSKA
ENIEQLLLSH RRAVKGAENA PHRIKSWIIR QWQKFQVLNP VVRWIIPPLR TVQGIGKQLA
HGSEIQSPFY LQWMRLVSIC TVYVAVMVPY RLTYDSLDRW NVIPICLRVF EALCEVVFWI
DIWFQFHMRT NQAAMELYEQ DQLVGYKRER LAFDLAATFP LDHFVTSFVS GSNRLMLWKW
LRLNRCLKVA NLVYYRNEIT RRSVSYEINR AQTLWLLYLL AMFWTSCAYF AVSIYDGFGT
EWQNWLPSSS LIAEDPSSDL LMLRLFRGLA FAVTAFVKKS RTFVPASQIN FAFAIVISFI
GQLVMALMIA EMANIFLLYI DNEVQFRKNH LVVERSLARW KVSTTLKRRA DNFLTSWWSS
HAGVDYQLIF DELPASVRPE GILAIVKEPL GLFVHHVFRP LLHEGEGEIN NKEQKAEETE
NPSQPNCGAK FQLGNLTYAI AKCLRFEGYP RGENVIVEGS VCKAMYFVVR GYLLSKSVSN
SEMYPVSRFR GGDYFGENGL LGHSVSLMTV TTMRACDLFV LNSDHLLQVL QSHSYFSLVL
ATAQLAVSQK KTTAEFVADW LRSDDDDEDM ESSDSSDSDG DESKSESGSE QDQVSQEVKL
RHRSQQLKRA LQGASQETMK LWVETFALFM EMLVPKGSME TKALIS
//
