ID W2JF50_PHYPR Unreviewed; 1403 AA.
AC W2JF50;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=L914_04798 {ECO:0000313|EMBL:ETM51354.1}, L916_04795
GN {ECO:0000313|EMBL:ETL45041.1}, L917_04696
GN {ECO:0000313|EMBL:ETL98194.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL45041.1, ECO:0000313|Proteomes:UP000053864};
RN [1] {ECO:0000313|EMBL:ETL98194.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL98194.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETL45041.1, ECO:0000313|Proteomes:UP000053864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ05E6 {ECO:0000313|EMBL:ETL45041.1,
RC ECO:0000313|Proteomes:UP000053864};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ05E6.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETM51354.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAC_01/95 {ECO:0000313|EMBL:ETM51354.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica IAC_01/95.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR EMBL; KI671851; ETL45041.1; -; Genomic_DNA.
DR EMBL; KI678588; ETL98194.1; -; Genomic_DNA.
DR EMBL; KI691834; ETM51354.1; -; Genomic_DNA.
DR EnsemblProtists; ETL45041; ETL45041; L916_04795.
DR EnsemblProtists; ETL98194; ETL98194; L917_04696.
DR EnsemblProtists; ETM51354; ETM51354; L914_04798.
DR VEuPathDB; FungiDB:PPTG_09205; -.
DR Proteomes; UP000053864; Unassembled WGS sequence.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR Proteomes; UP000054532; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT TRANSMEM 1196..1218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 897..921
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 932..964
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1241..1403
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 198..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..445
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 160210 MW; 0004DD930C95A708 CRC64;
MDMRSKAYPA LPDCRGLCLV IPRAGDLRFR PQIPAAFKQR LYIHADPRRR FWYARFQVRR
KFIVMSTQGD LYAKTSVATF TMADLPKQNV LSMPRVARGD LVKVLDLVQC SRSEGQQWEL
VFTRWRNGME TWLPLEVVQL YATNLLQEFF VNSINSWAFH GRLQPGNLSA YRTEVELWLF
HPEFQEFYKR LRLKRAGGST ASNPQQQARQ TSDRVPIKPE QLTAPVNTSH TSPAPHPTQT
AHPPALVTTA TESDPSEAVI REFEQRRLAR ERQERQEQLD RDRQQRLLQA QQQRQRQQQL
QEQERQWRLQ HEQQRKRAHE ELQRSQKEYQ QRLRMQQERE KLMELQQQEH GRQQRAKEQE
QLRQRLQQDK SQKKKSVHKQ IPTHRQETPM RTQLRPKERP NKSDSHSSQK SKDKHSSSIW
NDGGDDEYVP PEASDSEDSD TGEDSEVSED SLRSRPIRKR RRKRLLYSQV ELEDDDDEDL
PDLSQPRTRR RKTLQSSSED GSPVGTPTRA SKKRRRLRKP DSNGGKSSGV DVDLTQVSGD
EEETDNSVEL LAENGVTTPV QSNGGEAGDG EVISELDIDL DDDLDFEPSI LIGEIQCVCG
VTSVGGYRGQ WLQCWKEDCG VWEHADCVGY LTSFETRPPL KYLCSRCDPE AYSTRCMKAS
HRILDWLFQC CGSRNSKKLM DLLEDNTGVA NLPSDWKNAN YDNRTLAMHA ARNGLVKCLF
YLLDKRKVNL FETDSRSRNA LHHAALGGSV RCCQALLKRD RKLLLHQDLR GCMPFHLMLQ
SAKVNRLCVP FIREDAALVG MGDLDSNFPI HYACQAINKS TVEICQMIFT AQPSMLQEKS
SDGLYPLMIL CKATDTATAI RNRAVNAGEV CTSAKDIIAL MLDVDVFGDC LNQTAPNGWP
PLHFAAASGN HELVTHLCNI GLCDVQHAAK GSDQTALHIA AQNNHPLCVR ALLLEGLNVV
AKDTDGWIPM LYAQDAACVQ EFMHYKLTKQ LSRLHRMLGK FQQRGLVCRW QRRVARDPTC
FDILNDWCQS DTERIERMEG LLLSNPFLLR LDNKMDYVWK YIIQSIKNSP GQCSIGRENG
KAGTQQSGQK KLAFTFSRKH GCFWKQFVGM GMRLEPEDFR LPIIFSIDRN HTNNQGAENR
EGNLKLVLIR LAAGLLKEMP GLLVRGSNCD LEKNPLSADK EELAAQLLGF FVLGELVAHF
VLFAVPLSGI LDFTAAFLRC IACKGRYRLA HDKPWKNAGR SFAAGFEAVL PATLELFHAD
ELRVLFNGPE TSLNALQIDW NSAVDWNMCG QEVMGDNDVE NAKTWLPRLM NELVEEEQQL
LLLFMTGTFQ LVNERFFRSE GSSGRITVES FPETDSIFDH DAMFPTMEHK PDILRLPSYS
CYEAFKKGVL AVIRHTDKAF LPE
//
