ID W2L0X7_PHYPR Unreviewed; 1017 AA.
AC W2L0X7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:ETL91017.1};
DE Flags: Fragment;
GN ORFNames=L917_10393 {ECO:0000313|EMBL:ETL91017.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL91017.1};
RN [1] {ECO:0000313|EMBL:ETL91017.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL91017.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI680190; ETL91017.1; -; Genomic_DNA.
DR AlphaFoldDB; W2L0X7; -.
DR EnsemblProtists; ETL91017; ETL91017; L917_10393.
DR VEuPathDB; FungiDB:PPTG_12503; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24141; 2-5A-DEPENDENT RIBONUCLEASE; 1.
DR PANTHER; PTHR24141:SF1; 2-5A-DEPENDENT RIBONUCLEASE; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00248; ANK; 12.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:ETL91017.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Transferase {ECO:0000313|EMBL:ETL91017.1}.
FT REPEAT 231..263
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 454..716
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 966
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1017
FT /evidence="ECO:0000313|EMBL:ETL91017.1"
SQ SEQUENCE 1017 AA; 114055 MW; E4225A055BEB1486 CRC64;
MMEAASSGKV EVVRYLANQC HADVNVKNWD GETAFTRTGS IEVVRYLAEE CGVDVSATEE
NAKAALMNAS FRGNIEIVRY LIEECGADAH ATDESGRTAL IQACCLGKIR AVKYLIEKCG
VNVNAQDSFG RTAVMKAAES GAIDVVRYLA EKCGADMNSR NTTGYTALME AATNEKTDIV
RYLVEQWGAD ANARSNAGET ALMRAIRFDR IAVVRYLVKQ CGADVNAPDG WGWTALMNAA
RFDRIDIVQY LCRQGANVNV TDSLRYSALL RAIEGGNIKV IRYLVERYGA DVNIANCFGD
TALVVAAERG NIDVVRYFVE DVGVNMKPTS KDECTAVFLR AAGYGHKAVV QYLVEQLGAD
VNATDDDGDT ALLMATKRDD AGTVRYLVEQ CGADVHATCK DGYTALRIAT DRGYHQIVRI
LTPYVQQSLR VDTHTSGENT VISPLVPFIR PYEIELTFFS HDGNIGGDFR AKWLDADVVL
KLFIPDSSHS AFEDEVRMWQ QLRHPNVIKM YGACTAGPNL QFFVCEYATQ GSLSEPTNAC
KQMAWMKSNG YQPARIKRPW VWKWLHEAAL GLEYLHERRI IYGDLRCSNI LVGSDGMAKL
SNFGLSGSID VVSSRTTGAI RWQAPEVLKG EAPSQQSDVY SLGMCILEAA TGKRPWYTMP
EYHIRTTKLD WIPETTEGRE PGDLEGDVRA LVWSMCSQDP SQRLKLSSVR YELEQLSKID
NTNLSQTEQD HTSSYGEYRG GAMNELWMKV LVLMEKCDHI QYHQDFDKLK KLRELLRGST
HNSMLFRRFE TLLIEFYQMV KISPEQARIM RLSSTRATSN SVYAFQWRVK SLMASLGGTV
ETVETKEKRC PDQRYEQREG FISCISDTFL LLKDLKTSEE RAFFLRNLKT ELEDHQGEYT
VDQRAVMGKV YKELTSKLQK EGGSDLVPRW FIPWYELVID EWGKLGEGGF GSVFRAKWLD
SEVVVKRVIL DGSDVSFDTE RSMSTSYASA GPSTSEAAIN STKRAEALEM FRREVDI
//
