ID W2LED4_PHYPR Unreviewed; 4473 AA.
AC W2LED4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Dynein heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=L917_06486 {ECO:0000313|EMBL:ETL95757.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL95757.1};
RN [1] {ECO:0000313|EMBL:ETL95757.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL95757.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI678972; ETL95757.1; -; Genomic_DNA.
DR EnsemblProtists; ETL95757; ETL95757; L917_06486.
DR VEuPathDB; FungiDB:PPTG_02892; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR PANTHER; PTHR10676:SF398; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
FT DOMAIN 984..1415
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1619..1895
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 3199..3401
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2775..2808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4254..4290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2777..2808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4254..4275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4473 AA; 505674 MW; 7D22931ADC3440F0 CRC64;
MDSHLKTRRE SLGRPPSSPR TPTLHAIATG TALRTREQAR LELRQASDRE NAANPSPCDE
SSTEMDANNH ERLTSSSDTG GGDEDNVSPN IFEQSRMHVD EDELLELRRR PPVAFVVRNA
ATKEEEMQAA ATTTDSTVAR PKRGQSWHSP VHVPLSHRKL VQPPEIFRED PPFRPIAPRA
PTSARMGRWR GKAGNTPGRM TLNPTKLTPM ASPTPETRDQ LSDRAFVRKL REKNQELFDR
LVQRFSTLRR VSIQEQESHN STDNNALKLS GVEDAILFFL DAKHKHDVLY FKRKHTRGAK
SAETAKISLG LSSASATMGK YMPYDLERVD EAPRSDAGDY FMMTCSSLVH HTNNNDNDVS
GEVIPLSQWI MESKMFSLLL AGIPLFQKFL LRKTFVGWVR AIRRTIYRDN CKQIAHCLPF
ARQSFVRSIL QSSRALRDIQ RIRSLTLPTT RPAVDLVAVQ EHQKEQLAMA EMGLIDAKEN
LLGLMEEMVQ KIYDDLDPPT NLDELYSAEA TSVRTINTKW KSAPIAAMRQ RKTALQRQKD
AATHDISLLE TYIRVLDYMF TESLYLMIIY CVRHLREQLS AEENSGAVCA AVAIIGDSLE
LTPSFEQTKH IFLDGLARLI RLVSNFHFTK NATTWSNNRG TGLLAVVAES FESNLFSSEF
DLQSVLRKDP KFDKITRELV SELALWFDRA TQQMLTFESL RVIYVEVQSV QKPRGTDQRA
GNESNLTRLI GISGGELSRF LKNIANRLNV LDRSQYACQK VQSSWKVGFL EIQCRNSISE
ILELISQERN LLHQNLYALA VEGVTECVSV LQRATLLLED RPQLIEFFCE QMKQVRLLKE
GEKQLNQNIR NVDETVRALK RFAPSLGSDI SPQHNAMHQF LGKYTTLIQS HAKFAAKVLP
NITYQVNSAL QKYSLRCQKL LTVYDEFSDM EEQGDMEKNV GVFQEVVREL SAIEKATKLY
QEYQKMVGLK VVEIPSLAEA MTKWGEVQEL VNFTLQWLAA INSMENGIFS EQNWEVHADK
VHSFLPIIRE LQSRERAGFA DKMLGNIYQA VIDYLRKLSL VKEMAQPWVK IHHWKEILKL
MNILNYVSSI GVLITDGYTV TLGFLRSRDL WKYELQIREI TQKAHHDAVT EKKLNAMKCR
LQDAVLPIIR VHDSHELDLP RAIQLLESFE DDLLMIQSLA QVTASGSLQF QLVQWRDEVR
HCEEVLDKWI IVQRSRTKLS LLFSLRDVQH SVTDASFEFQ AIDRKWRGMM HSAKGTASLS
ICLREVVTIG FLVGAQESYA KLWLQLGTYL DEKRKYFPRF NFLSNHDLFQ LIIYARDPKH
LPRMVSKCFR GIQSLRMRRT TMELVTSTGS SGTGINEERV EDDVAVSSLQ AGVDIDAIYG
AAEGEELPIK PLRVTANSQF WMKELDERVS VAMVEAVNSA MNGSIVTLFE DNLESLIKPR
SSASNRRVET CTDSADNILC TTELNAQTDD REWTDYPLQV VLLCVHILVT HELSPLVRLD
RTGGAWQRFW QVFEQKKSNL IEFLARRASS PRERWIASSI LTLLLNQSQG IRELYEDQPL
TIVSQSAETA THQTDSDVSI HHYSYAAGDS FTWTKLPRFY YDPFEKKCTI HHLVKTFRYE
YSFIGSYTCP VLTPLCTRTV LAMSTALSLE HGLLVHSLSD GGSGRKRTLV RELAAMVGRE
CIDFDYSNGL TLTHFKRILR GVLQSNSMWL LFSGIEVSKM LRIFAQEMNQ IVDALRAHQN
CLVLDGSPVD ITNNELAVVV TCSLDYQHTH HQQIFLRLSS CFAPIACSSA NSEFIVEALL
LVNGFKDGKE LSDKLKALFC LLVDDCIPFI KDLPQNRLSF SFAIVRNVTH RLDTNVWQSA
EKSLVAAIWD EIHTKILPER RVAFLKCIRT IFPHAVDLEI NAFGTLVLRT PTGKSTTVSS
DFCENSANDE DAALSCDSDE EDEFHDLKIV KMRIQTAISS RRLSVSEIYV RKLLELYQIV
SKKVFVVVVG RGVCGKSTAI NVLSSVFAEK VPSSESTLFG DPDRQLRAVR LYPEAFNLKD
IYGEATGDSA WDDGFFSHFF RQNCVDVASI DNNVDYTLES IDGDSSLSPQ PTRRRSVFIP
EDAPTNRSLA PASWIVFDGV QDAFTLLEPL RGLMDSCPKD TKKMTLPNGD QVECTQQSLR
VFCEVESLQH WSPALLARCG LVYMQTEHIV PYTLLIKSWL QQQQPKRKRS SLAHLTKLLE
PTSEFVAKLM RTHLPSLLDV FKRYCPTFLE CSLTHIVANM LQLVTPFVVE IAKGVVEDES
EWMTDARIVV AYAATISIGV ILPRCGRMEF HLAAIKIAPH LIEEHPIFTL DASVTLFDVG
LRFQDHRVVL FQWSSSVLES SKPTRRSSFA YQSQFPRRTS AVLKARGRIV TSEDKEGDDE
LVGDTSTITS PLSIIYVPTA ATVSCSAWLT MIGLAKANAF VVGESGVGKT LVMENCLRQL
GKNDRVSATA LQINCTTTGV DTQRAIEHGM TGKLKGAHCP GVGKRALVLL LENLNLDTQD
SSTLVNGPCS AMIRQVIDGK GSFIKSTKEY VEFRDLAIWC SFSLSNFGYP RVPARLLRHF
HMMWLPSQTD QVFAQVVPMF SNYFRKRYEG PIFGDVTDIV YRLSQFPIQM FKRGRKLWKL
SAAVPHLLFS IGSVLSVFLS LMNASLSRIP ADPETEFELL TLYLTLQLHR NRFLERVNRD
QLESSARRIA KRLGFSSQSL SFLRSPSDFF FADCGDTEGI TKINAKTLAT FFVAGEERFH
WNRKSALKFG FSVPESGELS PHSSRGKGTR SVATNDEGIG LNSSNSVQET ANVRRSSLAM
FALKNGLPDE KVTTSLSFHQ LQNTLDVFSF LQSGARHLLL SGSDTADRRS TTMVACGALS
FQFREICTEL RLPIFIEHVK TIVLDAGLKA TQTVLYAEFE DLNAEEVALL VYLIRQDDLP
PHVYSSADKV KLHTIDHHPK PRPASPLTNR SSFLQDMSSV EKGKVTGAKK TTRSLAHLQT
VFRENVRRSL YIVLSFGCEA KLVEFMTQQP SVYYRFVSKT FPQWQDVSAE EICNSALQEW
TLLNENPDII GTFSSAQLRD MVLIIHRTAE SFKNDRLYQR LPSFTMRGRR FGAVTTRLDD
MLRVFTILFA FYHKKLGKQL RDLRKVLKFL TKRLTQTNVR VAKEETSEIA QSDASQAVVD
IAAQLAAQES IEKEARRLFL LDEERCVKIQ GEIEIKRASI QRELSKTLPD VLEATEALSQ
INKYHIVEMK SFTNPPQLVR LAMQAVCVLL DVPPTWSEAL RILADIRFLD RLRNFDKDNI
DPSIMDRVRF YVNHPDFSME NMRRASLAST TLCKWVLALV RYFEAMKRVA PTQKLLDEIE
QSYHIVVQRA DAEKKKLVDI EIHLSELRVL QAQKIQREAE LQRTQETRQR YKSSVTSFGQ
VIKQWHDVTK ERLESVEKQQ ENLLLDCVCV ATLIIFGAEK CHEAREKLVC QCQQAVQKNF
SSYPMAVDIP ALIQLSGEGL TTHFQRSISD MLEDEDEAFA TSLFLMDQIQ QVCFKIPFLV
DPLGRGISWI KEAYSNSTPS KGSRSFGENV VVDAGDPLFL RAIETCLAQS APPMVLVENA
SEGDEAAIEA ALELIVLLKE KSTCAVYFAA KSLDKVSSWT PKTWSHFAVV DFTPTRRDLD
NHFLTLFCHN SRAAAQNDIE SIRSKLSVEK SQEEALFQNF LVNLCAASDE AAKPSTAGLS
STTVSILSAW ISSGSGQQGF YNEDSMERIS MQLDDFMAVR HTRMQLQQDL RNLYTERRHA
LPFARRSRAF VLTEEGLAKL GLSLHLSLSR TLDNIGESLV DSQTKIQKSS EENKSWYLNV
SALTALTTTS FIRQRLAGIL TSLHRTYMFV LVLSIGEIDG EDETFDIQQQ IFAENVRERI
LRLCSRRNLS CHHSGQGDDC NLNNAAKLTA QRFVDQIVEA ALISTATSTS CTQLDDELLA
AFVKIKKGFL HSCEPAVQAL YLNMIENAND WKIYIKSTLA YEPADESTNI QSPRNAKSSW
IKSIQWPKWM MKHFRLLGRL QIHLSLFDSL PLRLIDDLIA THLGEREMNS ILSEGIVRPS
LDSLVKNANS STPLLVLTNS SEFAANGSSS VRHCARRSGI PVEKVVYMSV GHDATAKNPV
SIWSYREISA TTDSVVRAVT AVTRLKELST NSGWIIIDGA NTASASLSIT NALRLQIAHL
SGVKSTHHDF RLCIVENLAD SLGDLTLPAH RLFLESPQTL KQLYDSFLQS EQERKEAETN
LEKAQHKEEA PKRPPPLSRH ASSISSSLQR GNTEQQVRAA LWLFHSTFRL HLEATGSSIP
TDLFISQYEL DRVTRLIQLH LHQRVVASTV TSGTSSLQTA PPSAAATEAH WKTLMELAVL
IYLSRLWGDS RDNQCRQLLT WCFHSNTRDH NTEQESVLSR ILQLRQRLAS STMSPGSTLF
EKVELDFLPV DLQRQQHEYE SSSLLKNLLT IYA
//
