ID W2PYZ6_PHYPN Unreviewed; 698 AA.
AC W2PYZ6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=PPTG_14855 {ECO:0000313|EMBL:ETN05245.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN05245.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN05245.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN05245.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR EMBL; KI669601; ETN05245.1; -; Genomic_DNA.
DR EMBL; KI669601; ETN05246.1; -; Genomic_DNA.
DR EMBL; KI669601; ETN05247.1; -; Genomic_DNA.
DR EMBL; KI669601; ETN05248.1; -; Genomic_DNA.
DR RefSeq; XP_008909715.1; XM_008911467.1.
DR RefSeq; XP_008909716.1; XM_008911468.1.
DR RefSeq; XP_008909717.1; XM_008911469.1.
DR RefSeq; XP_008909718.1; XM_008911470.1.
DR AlphaFoldDB; W2PYZ6; -.
DR EnsemblProtists; ETN05245; ETN05245; PPTG_14855.
DR EnsemblProtists; ETN05246; ETN05246; PPTG_14855.
DR EnsemblProtists; ETN05247; ETN05247; PPTG_14855.
DR EnsemblProtists; ETN05248; ETN05248; PPTG_14855.
DR GeneID; 20184108; -.
DR VEuPathDB; FungiDB:PPTG_14855; -.
DR OrthoDB; 5478214at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF446; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 167..197
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 423..698
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
SQ SEQUENCE 698 AA; 78563 MW; 237F371B31464555 CRC64;
MHRYLRVHAR LNTTRHPRLI RCLQAAKMRI ANVSRASAIR RRNFLSIVAG LLLCTIKSVA
ATVTDTQADQ LEGADKRDVV GLRGLMPIVD GTYSNSSGGY GYYYGSSSGY NGYEDSSDGS
SSVKTVVIGV SIGVGLMLIT VCLTWKACVE CCTSTNRRSR HRAFIERPNA GWKCEVCLHT
NEFSQTGCVL CGTTAEELKI IRSRQEDTNT SAVVAPQVED STRSASNYLL MSSPRAAWVR
SLNTFHSGDL TDRQLVARER HQWKRCIGGQ NVRWVHIPFE VLQDNEALCS TIIKERDFQD
WHKRHPPKVS GPSRMSVSSV LFSDSSGQQL SWLTPGTAFV RDDDSRSQSR TARWRLAEEF
SASSRQYSKT VVRASTLVFS EKAQWFYQYS LKLCSSIVDG YHTIRIHRDR VLKQSMNLFM
SAPSGTLHRR LRVDFMDEAG VDGGGILREW LHLVCSQLFA EAPGLFTLTS SSAHQGYWFN
RTSAEKCTKQ LEMYIFFGKL LGKALLEGLL LNVRLSIPLL KHILGVPLKL SDLYLLDETV
YSSMMWILEN DNTNALGLNF TVEGVELIPS GADVTLHDGN KQLYVAKVAQ YYLFDSVRAE
ISSIMEGLRS VISDTVLHVF DFKELDLLLS GLPQIDVNDW RQHTDVRFYE QSTHEFELVG
WFWEVLESFS QDQRGRLLQY VTGSSGVPVE GFKVVLAI
//
