ID W2Q8F7_PHYPN Unreviewed; 1675 AA.
AC W2Q8F7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=PPTG_11847 {ECO:0000313|EMBL:ETN09453.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN09453.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN09453.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN09453.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; KI669585; ETN09453.1; -; Genomic_DNA.
DR RefSeq; XP_008905286.1; XM_008907038.1.
DR STRING; 761204.W2Q8F7; -.
DR EnsemblProtists; ETN09453; ETN09453; PPTG_11847.
DR GeneID; 20181362; -.
DR VEuPathDB; FungiDB:PPTG_11847; -.
DR OMA; TWVQHCT; -.
DR OrthoDB; 91406at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF23; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00695; DUSP; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018817}.
FT DOMAIN 435..582
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 795..1619
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 691..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1516..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1675 AA; 186674 MW; CA2854B3F61675CF CRC64;
MGNVMSMGGA PSADASTVDA YVSRLSDAEI KRYTDGYRRI CRVEGSASAS SANAPAFLQR
ASSSASNGSS SNLTGATVAA TTEATNGPLL SKKLFRNKVL GAFTMIPHSL ADRLFEVLDT
EHSGELSLVN VLSGLAWLKH GTYEEQVQLL FIIYDLDAAG EISREVLDRF MDVIYGRRRA
RHATTVQFLD RVFDGRAVLN PEEFRRTVQQ KDARGDALLV KWLAVLAAKI GTEDDPQILA
LEKTYNPVAI RRRIAQATLF SLTEVTALER QFQKMFDPKG GASTRIPSTQ FVEVLSAKGL
FPEMLLDRFC ECTAMPELVL FEEFCQFLSD FCRGSSRDEK VHCLFKIYSD RSTVRVDYAA
MKELIHVGVH CDTNANEDAV QDEERQVEEI SATQTAETGW DEEAFARWAA NAAAVQRLLD
QLAFAACIVF GLKPESAHLE KRIVEWHWRD ATRVIGIGQT WNLVGAEWWR KWCDYVNMDP
KNGSPYGSLP VPLIPPNTVV EVARNIRGNI ALRSASFNAD GSTNRPPRPG PIANWSLLMQ
SGSRRLKQKL VLARDFYMIP SQVYTVLFSW YSGGPDLIRS IVEVPTLTEP ELQIELFPLV
LRVARVDPSN GSVIRSGEEI LLSELSTPVS LLEATCRALL LLKLMDKARL WYFNEKAPDH
KIRLRDEYSN ELKKLTQDSV FLLEVQDDDG SWPLSQTDDT ITSSPSNSGS RQSTQGNGRM
TENNAIPASR KRQREHRPSL RTSDICSRGN LGEALGQRAS GSEAGSPTIE VDPVLASPVV
RKRFSKDAFK GPGLVGLDNL GNTCYMSSAL QCLSHTRLLV EYFKNEAYLK DINLRNRDGT
NGKLTAAFGE LLRVLWTSDR KRFAPNEFKK VLAKCSPQFA GSDQHDAQEL LACLLSSLSE
DLNRVVKKPY TEQPDSDGRP DALVAEEWWQ NHQKREFSVI VALFTGQYKS LLECSVCRYE
SARFEPFTFL QLSLPESNTR SIVLTIIFRT DRVPLRFSVR VKNGDTVQKM KEQVAAFLNR
MEKENSSAVT ADDEASKDEG DWTKVVIART SNLHTVESLL DDNLPLTQIH EKDQLTAFQL
DREEDLLPPR QVSPKPTELE SASNTTISLD TYQETRSNGK SVPASPKDAP KKGDMELVNG
SPVNGTALVD TNGVDKDSDP PTPTGSVNTN NESDPDDEDE LLPIGTSVYV RIDKTKDTVA
ARVIGSSANL GIVNVAYPSG VRRYHIPLSK VIERRQNDAF IFLVHRRVER STDSFTNAHI
TRLFGAPLVI RVSLRVTTAY NLYLLIWNRL RRIFNWQQPP SPLELDTNQG RKRVRTDTSS
LALGEHLTLT KFGFCLRLVT SHGIGCSRCE WLDGCLGCLL LPSSETVIPL AAEETVAIDW
DIRTLKEEYD PIQASKMDFD ASVQQHQRQD NQPLNLAHCM EIFTAKETIP EAYCGHCKTL
RPATKKMDLW RLPPLLVIHL KRFCFTQVSR RKLHHLVDFP LRGLQFGDFV ARKREPRGRL
SGLEYWLFLG GKLRADGQSE PSPTSSSEQA RPGSPRRVSS SALDAPAAAT AAVRGDDGFL
YDLYAVVNHV GALGGGHYFA YVLSDHDGKW KCFNDHQCKD IDEKEVVSSM AYILFYRRRD
TANVSIEQLF PPLPVDATGN GASSEEEAAS DKAQVEELLQ QSKLAASNGS GCIIS
//
