ID W2QUG2_PHYPN Unreviewed; 709 AA.
AC W2QUG2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=3-isopropylmalate dehydratase large subunit {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPTG_05918 {ECO:0000313|EMBL:ETN16807.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN16807.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN16807.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN16807.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI669568; ETN16807.1; -; Genomic_DNA.
DR RefSeq; XP_008897907.1; XM_008899659.1.
DR AlphaFoldDB; W2QUG2; -.
DR STRING; 761204.W2QUG2; -.
DR EnsemblProtists; ETN16807; ETN16807; PPTG_05918.
DR GeneID; 20175929; -.
DR VEuPathDB; FungiDB:PPTG_05918; -.
DR OMA; EDNEPHT; -.
DR OrthoDB; 1326656at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0016836; F:hydro-lyase activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1901607; P:alpha-amino acid biosynthetic process; IEA:UniProt.
DR CDD; cd01577; IPMI_Swivel; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR InterPro; IPR033940; IPMI_Swivel.
DR InterPro; IPR011827; LeuD_type2/HacB/DmdB.
DR NCBIfam; TIGR02087; LEUD_arch; 1.
DR PANTHER; PTHR43822:SF2; 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43822; HOMOACONITASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817}.
FT DOMAIN 62..423
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 563..619
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
FT REGION 448..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 76436 MW; 639D2401FCCD9A69 CRC64;
MASAPPMNVI EKILCHHAVG LTQPYVRVGD VLCVKADWTI ASELTFQAMD TMHAAIGRPP
LHRPDRFWLA LDHTVDPRVN HLPKQKALIE MSTNFAKTHG LTDFQPANTT IMHTEFARKR
AQPGQIVIGA DSHTCSAGGM GAFAAGLGAG DVVMPLVTGQ TWFKVPEVCY IEFVGAPSFG
IGGKDVILHI LGELKRNTVA FERAVYYGGA GLKYLSDDAR FAVANMSTEF GGIAGVFQAD
TITQRVLEAR ESHFDEALFF EPDEGCNYAA HHVINLADVK PLIALYPSPD NCVSVQEKLG
MTLDGCFIGA CTTTQEDLIL GAMVLQQAML EGKRPSANGK RRVTPGSLEI IDRLKELGLI
RIYEEAGFTV GVPSCSFCVG IGADVAGEGE VWLSSQNRNF RNRMGKGSIG NLSSAAVVAA
SSFDMEVVDP LPYLEKINKE DFDRYRNWVE PDSSTPSPAK TTKSYTVTEP KPVLASGDDE
DSIQQAKEQA AVAELEAALP PKFSGKVQKF GDNIDTDAVI PAQFMGLNKS SPLWPPECET
ELDVLAAKSF AYVRPEFPQK VREGFNIIVA GTAFGSGSSR EEAAICLKAV GVQAVIAKSF
AYIYARNQPN NALLGIVVTD EKFHQLAAEG EEVTVDLRNR VVSVKDHQVA FSLTQLEEAF
LNGGGLKTLF KQHKADLFRA AMRGKAPKVI SSGGVGCGEG CGDAATPSW
//
