ID W2QWB8_PHYPN Unreviewed; 1245 AA.
AC W2QWB8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=PPTG_05075 {ECO:0000313|EMBL:ETN17216.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN17216.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN17216.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN17216.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; KI669567; ETN17216.1; -; Genomic_DNA.
DR RefSeq; XP_008896799.1; XM_008898551.1.
DR AlphaFoldDB; W2QWB8; -.
DR EnsemblProtists; ETN17216; ETN17216; PPTG_05075.
DR GeneID; 20175140; -.
DR VEuPathDB; FungiDB:PPTG_05075; -.
DR OrthoDB; 65703at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR24189; MYOTROPHIN; 1.
DR PANTHER; PTHR24189:SF50; MYOTROPHIN-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT REPEAT 40..67
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 84..116
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 117..149
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 150..182
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 183..215
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 310..533
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 1245 AA; 140073 MW; 7959CC44CCDD4A30 CRC64;
MKCKQEESLK RVWDKSDQEA AAAIITLLHQ GVDAKSPDGG AAIALQYALR NSRADVISLL
LERGADVMSL LLEQGADVGT QDEDGKTALH YAVTSHNTDV MSLLLERGAD LAARYEDDET
ILHYAVRNGD VDVISLLLEK GADVAATDNN GEIALHYAAS FGHTERILLL LDRGSDVNAS
DNDQLTVLHH AVTRCSPEAV LLLLNKGADA NALTKDGLNP LSHMILVKED DPDDDYLGVV
RLLCSQEPKL KLPPSTQSLA INQLGMLACA QYWQDRYEKK QPLLEIPSEV VKGGENAVEV
YLAELEKTDS SEVVHRQKIC VVGRTKWGKT SLVRSITEET SVLVPLEDRT IGIEVFPLRF
TVDGDGNKMK ATHHDVTFWD FAGQGVYRVA HAVFFSKRTL YLVCVDLAAY NEILEQAKKE
SKTQRDEVPQ RFFEKHILRW IVLILLRQPE AEFKLIGTKH DEVSDSSRSE ISHDIRDRLG
QFLEKLDGSI QITGHAATAL KKEFEEGLVT TSVTNVESIQ KVKNSIKHTI TAKPHLSFKM
PITYTRVINY ILEKRQSVVG ATNQDRMDKM IVSVRQLCKD LLKLPDFPQD TDCREILRVL
HELGDVLWYK GIDEELEKWI ILDPSVVLDL VREVINHKYK EEVDEQYKVL SQNGILPHSL
LMTFPSWKSL AAVEDKMVHL FKQLLHRLNL VYPVNDMEAI DKADILVPMY WKTRETPKAD
LKLLATQKTI LTQDFGDSWH VATWRYWLPI VVSDAIFVNF VVKCYRPFVH RSARRAYFES
SVRREFRAVV NHSANKTGQY NDILIEVAAP TEKLAWAEMM YFVTDMEKIL EKDYPGLTKH
ARVKRFIVDD GEDRGVNDLM ENPEDGKRQR AKARWLPPDF GWFTQCAWKN GGVYEIHQLR
HQLEAVKNIV VTSESCRLPR LWTLLYPRKG SHVELRIHSD VSGKCEHKAL QIPVNDNILT
RYPKMFQFCI SALSAASVAI PNAVAVAAVN QVLEASKSAL NQKITAKEVL DRANLGAGEE
KSSHELGMGP AERRAFLLQL LALHDPSFNE DTIGRACQLQ RGATKEGYYI WLSDDEYSDL
KHCVTLCDPE SGPPVIPILA TTSSPEPSIS LRIIGAEGTW KPLTKMYCAW ELLRDLKVVG
NGSTSKTACT EIGTSWESTA VKLNFVDSHI KMLRDCTLVI RVKKARSFTC CFRSDKVIVQ
GETQLCDHVN ANCSTTQLIN VPISVATGTL TRTVNCQIKI KFIGP
//
