ID W2R7V5_PHYPN Unreviewed; 4127 AA.
AC W2R7V5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Dynein heavy chain 6, axonemal {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPTG_01653 {ECO:0000313|EMBL:ETN21493.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN21493.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN21493.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN21493.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI669563; ETN21493.1; -; Genomic_DNA.
DR RefSeq; XP_008893281.1; XM_008895033.1.
DR STRING; 761204.W2R7V5; -.
DR EnsemblProtists; ETN21493; ETN21493; PPTG_01653.
DR GeneID; 20171934; -.
DR VEuPathDB; FungiDB:PPTG_01653; -.
DR OMA; VESFDWQ; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 2.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817}.
FT DOMAIN 851..1252
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1385..1710
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1881..2003
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2241..2329
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2387..2646
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2660..2989
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3018..3237
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3503..3619
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3662..3800
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3807..4123
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2871..2936
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3186..3213
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4127 AA; 464053 MW; 955E1CCC5B28FB31 CRC64;
MDGRDDGESR DGAKRRGVSI GPQANQILQR LYEPNLGPGS PADDRNPLSP VKRSAPTRNA
VLKPKFQTRM KKNASVATIL NSVPARTRAG VPTPISSGIT PLSTSASMMS LPPGVIHPSL
HKASERIRTL QDKTHISSTI TRSSTLAEER NQSGGESGSY ACLSPASKAA QRKSLATESS
FTASLNLDPR YLKEFKSGNF LYLRKKKNTD LVMYALEVVE HFEVDRSDYY TMSLEGVTHF
TTEHSEFWTL DKWETEYSRF MKMLAIPFFQ KYKMWKNFNM WKTSVRTFKM RNAKKALNER
LFLLAPSLQS TLLGLRSLCL DVTKLELIHF SNRQTYSLRD FELEQQKTRT QVTQQLASFS
AKSLQMCVKA CDDVIDSFLV ANKISADHKM TFMERAALRK QCRTLTSFLR LADFLTIDAT
IQLTIRSFQQ LYGILAAGKA QLTGTATSVP ETKQPTGNIQ ANSKNPGKSG QTNTSPFTAI
FAVAVEMDPV TSALNATPNH DAWNGALQRA LKEALRMVET PARHLGHESL APYTTASAED
EGKDVWSVEQ LNVALILNED AKFSILTNDI FVALDEAFEA VEDYMDVFTP FHQIYSENEG
QVTHLMETYA DAPLDFFSES VEKYRSQGQS FTEIPDAATV GIFRVDSSEF KSRLLPNPEK
CILGIRALIP KLMKKTSAEL LETLNDLSPV AFSTPSTPDA FVNKVVHMTK VGTMLPDLRN
RYRRVYEMGV LMDNYDWRVP DDIKEDIILM KEGVLSLEGT VTRFEGEIDS ETARFSQIIL
DSIAPLNRNA QMLLEKLDHP KLSTIKTPMN EALSFLGAQE DSLNQLVEES KMLAMFQTQL
KQTVSEFNEI NEVAAHFELK MKLWSGLDAW QKLAVSYSDT IFDDIDVAAI SKQVQMYVKV
AYQAQKQLPG NEAADLLQRE VEKFKLVLPV VTDLRSPSLK DRHWKQIHDA LGFQMKGESS
MTLGGLIERN VMKHGETISA AAVSAQQEAV LEEMLKKVTD AWATTEFEVK PYKESKDVFV
LGSVEEVTAK LDDSIVTIST IMGSRFIGAI QEEVEGWRKK LVTLQETLDE WLLVQKNWMY
LENIFSAPDI QRQLPDASKI FSHVDASWKT IMRRTNENPH VLTSGTFPGI KETLLQHNVH
LDKIQKNLED YLETKRMAFP RFYFLSNDEL LEILAQSKNP QAVQPHLRKC FENLVKLDFG
DIPGSVDMIA MYSSENERVP LGKNLKARGN VEDWLKALEV SMKQSIYKLM KAGLLDYDTK
QRSVWVCDHP GQVVATVAQM TWARSTEEAL NSSNPVEEMH AWYKRNLYEL NELIVKIRGD
LSSLERKVIV ALVTTDVHAR DIVESLWTEK VDSVGNFIWQ QQLRYYWDVQ ADDVLIRHSD
SVIQYGYEYM GATSRLVITP LTDRCWMTLT GAYGMKLGAA PAGPAGTGKT ESSKDLAKAM
AIQCVVFNCS DQIDYKMMGK LFRGLAQAGN WTCLDEFNRI DIEVLSVVAQ QLLILREGRI
QGKEHINFMG IEILLKDHHV IVTMNPGYAG RTELPDNLKV CFRPVSMMVP DYALIAEIML
FAEGFGDART LSRKMCKLYI LCSEQLSQQP HYDYGLRAVK SVLVMAGSLK RANPDLNEDV
TLIRALRDSN IPKFLADDLP LFHAIVLDLF PGTDIPPNDY GELQASLEEE ITKAGLQKVP
TYITKVIQLF DIFNVRFGGT LVGPTGAGKT SCYRTLQSTM TSLRTKGSKN PVYQTVHARV
LNPKCISMGE LYGEFNEATQ EWHDGLASTI MREAVADETS DVKWTVFDGP IDALWIENMN
TVLDDNMTLC LANGERIKLK SEMKMLFEVM DLAVASPATV SRIGVVYMTA TDLGWMPFVK
TWMEKELPTD FPPDGLKRLD FLITSYVEKC IQFVRRKSFE LVPTVDMNLA TSLCRLFACL
FSSANGVNYL TMKNEEMLEL LDKVFAFSLF WSVGATMTVD THEQFDNFAR ELMTDAKLNI
PNAGLVFDYF VDVEQAKFRA WSEVVPKFVY NNQIPYFKMT VATPDSVRFT FLLRTLTAAK
RPAYVTGVTG TGKTVIVQDL LQELTSGPMI PTGDNGENGE NSSAPASNFM TIFINFSAQT
SSLVTQLTIE NKLEKKRKNL LGPVAGKRMI IFVDDVNLPA VEEYGAQAPI ELLRQFLDFG
GFYDRDKLFW KDMADTMLLA AAAPAGGGRS HCTPRFVRHF HVLSMYPAGE TSLKLIFASI
LGGFLEKFAP SVKAMKDGII SSVIEIYNRV TLELLPTPNK FHYTFNLRDV SKVFQGILMI
TPSKCPDADS MNRLWVHEAS RVFQDRLINA SDQTWFEELV CSLLQRFFNC NWSREALFHS
PCPLTFGDFF KPGTPTPLYE YCNDVTKVTK IMDDFLENYN VTFANKMNLV FFRDAIGHLS
RLVRILRQPR GNAMLIGVGG SGKQSLARLG AFMVEAKCVQ IEITRGYGTN EFHEDLKKLM
ISAGVGGQST VFLFTDSQIV EESFLEDINN VLNSGEVPNL FPQDEMDRII ADMRPIVKAM
EIPETRDNCV STFIERVRNY LHIVLAMSPV GSALRVRCRA FPSLINCCTI DWYMNWPREA
LQSVADRLLA SVSLPSEDVR TALVDMCSIV HTTSNDFGED FLSQLQRYVY TTPKSYLDLI
GLYLKMLQEK RAVLQTIKNR MEVGVKKLEE TNSIVDSLKS ELIELQPILA KKAVEAEELL
KRVSVDQKAA AVVRERVSQD EATVTKQAEE VAIVQADAQK DLDVAMPALN NAIKALDSLS
KNDITEVKSF AKPPEAVETV MNAVCLLFNE KQSWDSAKKI LGDVAFLDKL KNFDKDNIPA
ATLKKLSKAV SEPGMAVEVV SKVSKAATSL CMWVHAMDVY SKVAKEVGPK KENLERMNQK
LAEANAILSQ KQEELRVVNE NVAMLEKQCK DTLDEKDKLA NDAAVTEKRL VRAEKLISGL
SVEGARWKES VASLSESILA LIGDTFLAAA CISYYGPFTG GFRQRIVDQW VTQTQELHIP
CSSGYSLSIT LGSPVEIREW QLNGLPTDST STDNAILVTR GERWPLMIDP QGQANKWIKK
TLTQNLETTK MTNANLLRSL ETCIRNGKAL LIEDIDETLE PSLEPILQKA IYKQGGRVLI
RLGDSDVDYD PNFKLFLTTK LPNPHYLPEV YIKVTVINFT VTMDGLEDQL LGDVVRHERP
DIEEKKNRLV VTMAQDKKQL KEIEDRILKQ LSESSGNVLD DQDLIDTLQS SNVTSRIIKE
RVLESESTEI EINRAREEYR CVATRGSIIY FVVANLALID PMYQYSLPFF QRLFNICFDE
APKADTLQKR LTNLVDFQTR YIYVNICRGL FEVHKVLFSM LICCKILLHS GKISAREWSL
YLRGAPPGTD RSLQQPNPQP THISEAQWDL ISELETLVTG YTEDAEGQKT QVQAFQGLCT
SLTNVWSRWL IWLDDPEFLS NPNSCPGNFG STLNAFQKVL LLRGLAEEKV PQAVLNMIST
EMGTEFGRNA STTMEEIYND TDRKTPCIFV LSAGADPTGM LLRFAKEMSF IDRLHLISLG
QGQGPRAEKL IESSQGSGDW VLLQNCHLAK SWMPKLEKLV EDMGQRTDEQ CQSTFRLFLT
SFPAAYFPVT VLQNGIKLTN EPPKGIRANL LRSFNTLLSE EVLESFHFLG NFDTGEAKNH
VWKSLLCALT FFHAIVQERR KFGALGWNIK YEFNDTDLET SLASLRKFLE EQPIIPWDAL
RYVTGQINYG GRVTDDWDRR CLTSILSNFY TPEVLNSGHS YSTSGSYHVP KELSHSSIQS
YLSSLPAFDN PELFGMHENA NVTYERNESA NMMQLILSLE PRDGGGGGGK SNDQRVLDLA
ISIQEHLPAD LNVEEAGPTT FKTREVAGTV VMDSLATVLS QEVIKFNTLL RRMRSSLRDI
QKAINGLIVM SSDLDNMYMA FLNGKVPQLW SSVSFASLKP LASWVRDLLD RVSFFRQWLL
HGEPVVFQLN VFFFPQGFMT GTLQNFARKY QTAIDSLAFT FTVMDVENAG QLTQSPTDGI
YVDGLWLQGA KWSPTRRLLE DAKPGEMFSA MSIVHFLPAT SAVASNPVLS PGIMMYPCPV
YKTSVRQGTL STTGISTNYV IAVQLPSDRP PNYWVMMGAA FLLNLDN
//
