ID W2RB12_PHYPN Unreviewed; 1136 AA.
AC W2RB12;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=PPTG_02467 {ECO:0000313|EMBL:ETN22562.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN22562.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN22562.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN22562.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KI669562; ETN22562.1; -; Genomic_DNA.
DR RefSeq; XP_008891801.1; XM_008893553.1.
DR AlphaFoldDB; W2RB12; -.
DR STRING; 761204.W2RB12; -.
DR EnsemblProtists; ETN22562; ETN22562; PPTG_02467.
DR GeneID; 20172703; -.
DR VEuPathDB; FungiDB:PPTG_02467; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 46..336
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 632..1093
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1136 AA; 123051 MW; 2AA341055D6890A4 CRC64;
MFSLDAPLAP AIDAFVDPEN DDAAQKTGLN TVVMQVHRQV SMEALIQALG AYLTSGDDKV
RSRATLLLAE VLTRLPELQL TPSAVQLLMT FFADRLADFP SASACLRALL ALETHHAAQV
QSPRTTVALI LKLGKTLHIP QLGQAMRKMC FDLMQLALMQ PTVVELLLDS VPASKDAQDA
SVDDAEQSED LGRQFAQTFL SAMEGEKDPR NLLLCMQVAR TLLSKLEPVF SRSDALLQQY
FDVVSCYFPI IFTPPPNDPY GITSEGLILS LRHAFAASDL LAPLVLPFLL KKLASTVVEA
KLDAIQTLVF CGERYSVNAL LLQMHAVATA LYDEVLDGEK QEVIAEARQA ISRFSGVVAR
AKAQDTPGAA YAWSKFVVDM TARAAGELRE NAADSMVSVS AGQVLTALGR ESSLSFAHVL
KIAVPLLVEQ LTNESSGSDS VSSKCEAALA RILLLVDTID REIDQSGQAQ PMRPHAAALI
DALVNFLSSD QDNQTNPGSS PTARCVAVEA LCHLLTFPPS PIVAPAQVKA LINLFTRMLL
LDPAAEVRTA CLQSLKEIST VSTASVTSTN SGEHPVTGGY AAFVVEISLA RLMAAVNEGS
DQEDDDDEEG TGVATVLAAS NRNFDSFFEE ALLAITELCR EASIFQATIF LLIDLCVEKD
DGKQSAIGFC EAEGDATRQR HVDCILDAVA KIVEINAGDR SSMEFCVKAS SSASIIFRLL
TAVETSAARA TAASSDKPGL VDDVKLSACV RIFRAVMQNV SSATQQQLVD AVVPAFLRTN
PSEPASLQLV PLFAAVINSA ARDVTIPESS LVINRLLELA QSGATAVPES SPRQLQLVYT
EAALSAAKSL ASIMNKMSDG AEFDALIDLL LSQKLAVVIS NPYESFTVRV AALQIYAWIA
KGLIIRGHKV HAPVCLRFLC SFLTPDGDVN MEQDDDQQAA ALRMEVGKTF KLLVSEYPDV
LNRKCGAFIT FLYRQRLFDL VFPVLLEYIR AHIGEETSVA ALVAFAQVIA HSPKAIYLPH
LAQIFPLMVQ ALKTDDRELG SAAIQTFKPL LLESVESAKP FLKDVFPGLL KQAQFGPAAK
DRHAALECLA KLATIPYELV HPYKDIVLRK LLLVLDDRKR LVRHMAVRVR NQWSIL
//