ID   W2RWB9_9EURO            Unreviewed;       743 AA.
AC   W2RWB9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1541_05022 {ECO:0000313|EMBL:ETN40742.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN40742.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN40742.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN40742.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB822720; ETN40742.1; -; Genomic_DNA.
DR   RefSeq; XP_008717585.1; XM_008719363.1.
DR   AlphaFoldDB; W2RWB9; -.
DR   STRING; 1220924.W2RWB9; -.
DR   GeneID; 19972361; -.
DR   VEuPathDB; FungiDB:HMPREF1541_05022; -.
DR   eggNOG; ENOG502QT3Z; Eukaryota.
DR   HOGENOM; CLU_021479_0_0_1; -.
DR   InParanoid; W2RWB9; -.
DR   OrthoDB; 2727909at2759; -.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   PANTHER; PTHR21708:SF25; PROTEIN PAM1-RELATED; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT   DOMAIN          8..163
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          197..319
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
FT   REGION          320..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          512..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..350
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..385
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..673
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..736
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  80690 MW;  30EB2435C57AAC0D CRC64;
     MSTELRRVCT VGGNAISAFL SWRLQATNAC DVTLVWKANY QTVAQYGVSF KSDKFGNERF
     KPRYVVQNPD DAAHQNVAFD YVILCVKALP DVYNLADIIQ SVVTKQHTCI LVNTTNTLGV
     EKELEERFPT NVVLSLVSGA DLTQLGSSEF EHSGSTEMWV GPANVNSAIP EEIQKDMAEA
     LAMTLTTGQV DCKVAPNIRQ QQFERMIGPI AFHPASVIFE TPNHTELLQK PGVEDLVKDI
     IQELVTLAAV YECEFPSDFA SSVIRTMTAR AEPSTMYQDF SSRRPMEVET YLGSPVKLAK
     ASGISVPRLE TLYTMMRHVN TSNKDRSPPP PSPAVAQSVQ PPPRTASMQP PPRMPNGSMA
     GGPRPPRGPG GPSGPPGPMG PGRRGPPPVN GFRGFPRENG MQRRPSFDEN GLDEFSHVVL
     YDDLPEGDVA GDGLHLGGLS VRERELMLRE KEIHLKQQEM AMRGRGAGRK PPMRPQDFDD
     DDEDDDFVDP MQPRFGQPPI DDNIDMMSVT SRRTKRHPSQ GQMRRDMFGG GPPMRGGYNS
     RPYMSRNRTS AQLMSDMPAL GENILDNPMM GFSSNRYGTV DRGEMHNESR TNSLTAARLH
     EMGGGGGPYP GPSPAPPSRR TSRSPGNPLG PVGRPMGRPS PPHDPYMQNG PPRNGRPSPP
     GAMPAPTPRY PPGHGNAVHP HQVEQQVGVS KPYPPKAPPK SLTGSASASA GSGDSGSANI
     ESEPSAHSSQ SSFAPRAVMT AAR
//