ID   W2RXH8_9EURO            Unreviewed;       342 AA.
AC   W2RXH8;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN   ORFNames=HMPREF1541_04750 {ECO:0000313|EMBL:ETN40473.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN40473.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN40473.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN40473.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072}.
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DR   EMBL; KB822720; ETN40473.1; -; Genomic_DNA.
DR   RefSeq; XP_008717316.1; XM_008719094.1.
DR   AlphaFoldDB; W2RXH8; -.
DR   STRING; 1220924.W2RXH8; -.
DR   GeneID; 19972089; -.
DR   VEuPathDB; FungiDB:HMPREF1541_04750; -.
DR   eggNOG; KOG1198; Eukaryota.
DR   HOGENOM; CLU_026673_16_5_1; -.
DR   InParanoid; W2RXH8; -.
DR   OrthoDB; 1751130at2759; -.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   CDD; cd08249; enoyl_reductase_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR   PANTHER; PTHR45348; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR   PANTHER; PTHR45348:SF2; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT   DOMAIN          10..337
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   342 AA;  36577 MW;  776EB37963E7857E CRC64;
     MKGVICEKGG AGLKVVDDLQ KPKPGPDQLL VKSLYIGLAP VDKFMIDYGQ LVDEWPVTLG
     ADGSGKVVEL GENAGKYGFE VGDYVFGCVR LGKKGHGQGQ EYFLKEAPVT FKKPEKLTII
     QAATIGAGAS TAGLGVWEGL NVAFPGASEP SPKDEWAIVF GGAGSVGRAA VQVLLLAGYK
     VATTCSSRSK KDLEQLGAVP VDYKQPEADQ VEEFMRVTGG KFCRIFDATS ADDPTLAKEL
     FKRISGDKYF ATTNDWPGPP DFEGGKTYHI ELGPIGNPEA TKLNEVLKKH IPVLTKYLAD
     GRLTTPEYEV FGEGFEAAVN AYAYQSSGKG GNKKVVVKVQ DE
//