ID W2SF35_NECAM Unreviewed; 206 AA.
AC W2SF35;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=NECAME_05710 {ECO:0000313|EMBL:ETN68229.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN68229.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; KI669304; ETN68229.1; -; Genomic_DNA.
DR RefSeq; XP_013290456.1; XM_013435002.1.
DR AlphaFoldDB; W2SF35; -.
DR STRING; 51031.W2SF35; -.
DR EnsemblMetazoa; NECAME_05710; NECAME_05710; NECAME_05710.
DR GeneID; 25345742; -.
DR KEGG; nai:NECAME_05710; -.
DR CTD; 25345742; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF80; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 31..206
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 206 AA; 23294 MW; 11FDE71EB60A3FAE CRC64;
MDVIVRRRRI ETTVVAPHCY HKYGNHHTAK KVSTVSLGQW ACLEQLNYIC CLPNRCSVND
VDETVRSLMQ AMFDAVKVIT MDLNTGICRV AWQRFPLSAP CVIECLKIST KEKCERIAKF
AFDYATKYGR NKVTAVHKAN IMKLGDGLFL GTCQKVASRY PKIVFDSMII DNTCMQLVSN
PEQFDVMVMP NLYGNIIDNL AAGFVK
//
