ID W2SQG4_NECAM Unreviewed; 626 AA.
AC W2SQG4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=SH3 domain protein {ECO:0000313|EMBL:ETN70932.1};
GN ORFNames=NECAME_04783 {ECO:0000313|EMBL:ETN70932.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN70932.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI668876; ETN70932.1; -; Genomic_DNA.
DR RefSeq; XP_013293159.1; XM_013437705.1.
DR AlphaFoldDB; W2SQG4; -.
DR STRING; 51031.W2SQG4; -.
DR EnsemblMetazoa; NECAME_04783; NECAME_04783; NECAME_04783.
DR GeneID; 25344815; -.
DR KEGG; nai:NECAME_04783; -.
DR CTD; 25344815; -.
DR OMA; QKKGRTH; -.
DR OrthoDB; 5476196at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047163; ASPP1/2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24131:SF10; ANKYRIN-REPEAT, SH3-DOMAIN, AND PROLINE-RICH-REGION CONTAINING PROTEIN, ISOFORM B; 1.
DR PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 442..474
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 475..500
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 541..605
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 85..164
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 234..256
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 69848 MW; 9DC580D5D4BDD53B CRC64;
MTKPPIRVVA QPPSRFSSQS QHYPASSAAA STIPLNTSQC MVSSQPKLSM YTVPTISVPP
MANSREVDRR QAMRAHSGTD AVHKINMIRR DLAEEEGELR RLSELENETR NLSKRNGEKE
AELSHLSAEL REQQNILRTA AGRVEILRRQ IEELYRRRQA AAAAALSEQR KMQQQAVRLQ
ETTRSAAIVE RPRASVEPFQ VNVPIQRDPE PDTKEDKCTV VDVSLDSEDS SKPIPSPPSE
PVEIAPFLPK YPPPSINDPG SSNRSDASPS PPKDPHPTAG ELQTSTAEAP EKPMRMRELV
RQQEFSISSF ADSLDESRLR SGKTDLVSIR TDSLKAAKRR SWAASEGTTL SEADTIRRIL
EEQRRGRNHF IPELPTPHEE PKMEVDRRTV KGILRPLGLK KERRRIEFDP LALMLDAALE
GELDLVKSSA AKLSDVSVAN DEGITALHNA ICAGHYEIVK FLIEADADVN AQDSDGWTPL
HCAASCNNLP MVRQLVEGGA CVLASTLSDM ETPVEKCEED EEGYDGCLRY LTTAHNATGA
INNGTVYAAY DYDAQFDDEL SFKAGDELRV ISKDDKEKNW WTCERVGHDG ETGLVPRTYV
ALYPALRYRK RCEKLFFLLL IVFLMV
//
