ID W2T5N0_NECAM Unreviewed; 498 AA.
AC W2T5N0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=RasGEF domain protein {ECO:0000313|EMBL:ETN77213.1};
GN ORFNames=NECAME_11228 {ECO:0000313|EMBL:ETN77213.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN77213.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660187; ETN77213.1; -; Genomic_DNA.
DR RefSeq; XP_013299440.1; XM_013443986.1.
DR AlphaFoldDB; W2T5N0; -.
DR STRING; 51031.W2T5N0; -.
DR EnsemblMetazoa; NECAME_11228; NECAME_11228; NECAME_11228.
DR GeneID; 25351257; -.
DR KEGG; nai:NECAME_11228; -.
DR CTD; 25351257; -.
DR OMA; ISQTWEH; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF356; FI05912P-RELATED; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 36..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 203..461
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT COILED 153..187
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 498 AA; 56816 MW; 07695C77F4296721 CRC64;
MLAASPLMAS STKRRDLELN TRKSDKFDQN DIVVDAMGNV LSGSSEALIA RLLPTRDGVP
DANYMFTLLL NLRTVMSPEE LMQKIVQQCM FTQNADAVNF CREGRDRMFS HLLRLCREWV
TSIPHDFRSE HMRTRLNELL GLCSVDRNFK QKAADLQSTL KSTINRLERY DKAVKNLQKT
LSENTQRPMQ SDILVGLITV CPDPKIVAQQ LTHIEMERFS MVGVDEILVA LASNDLADLG
RNRNGPGGSI SFYVEWFNRL SSFAATEVLR QLKKKHRVEV IEYLIDVAKE CCEIGNFNSL
MAIVAGLSLP AVSRMKRTPI KFQDNLNEFQ WSRVEKSKLE ILQHQLDPSG NFLSYRATMK
AAQWRAETAG SNQRIVIPFF VLLLKDLFLI YHGSVRTLPN GHLNFVRMKE LSTMPGYYKL
LDLLPVFEKA YSQIAEQLRS VVRWKGILCS FPKNAAVLQY TLVCTLYGER ESMLASFECE
PAESAAEREQ LKKLKVRQ
//
