ID W2T7Y0_NECAM Unreviewed; 481 AA.
AC W2T7Y0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Endopeptidase La {ECO:0000313|EMBL:ETN78130.1};
DE Flags: Fragment;
GN ORFNames=NECAME_18245 {ECO:0000313|EMBL:ETN78130.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN78130.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; KI660066; ETN78130.1; -; Genomic_DNA.
DR RefSeq; XP_013300357.1; XM_013444903.1.
DR AlphaFoldDB; W2T7Y0; -.
DR STRING; 51031.W2T7Y0; -.
DR EnsemblMetazoa; NECAME_18245; NECAME_18245; NECAME_18245.
DR GeneID; 25358270; -.
DR KEGG; nai:NECAME_18245; -.
DR CTD; 25358270; -.
DR OMA; FDELACN; -.
DR OrthoDB; 1103874at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19500; RecA-like_Lon; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR004815; Lon_bac/euk-typ.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008268; Peptidase_S16_AS.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00763; lon; 1.
DR PANTHER; PTHR43718; LON PROTEASE; 1.
DR PANTHER; PTHR43718:SF2; LON PROTEASE HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF05362; Lon_C; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
DR PROSITE; PS01046; LON_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01122}.
FT DOMAIN 294..481
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN78130.1"
SQ SEQUENCE 481 AA; 53226 MW; 0A16881B59441AF4 CRC64;
NYLDWLTNVP WGITSEENYD LQKAKAALDK GHYGMKDVKE RILEFIAVNM KHVGGKILCL
HGPPGTGKTS IARSIAEALN REYFRFSVGG MTDVAEIKGH RRTYVGAMPG KMIQCLKKVH
TENPLVLIDE VDKIGSAGYH GDPASALLEL LDPEQNANFN DHFLDVPVDL SRVLFLCTAN
VVDQIPGPLK DRMELIDVSG YLAEEKIEIA QRSLTEEQLT IDKDAVENII KHYCRESGVR
NLQKHIDRIF RKAALQIADN PSDSSTPSTI VVNNENLEKF VGRPKFTSDR MYEETPPGVI
MGLAWTAMGG SALYIEAVLK KPVDYGSDKD GSLECTGNLG DVMKESVRAA LTVAKSILVK
DEPDNKFFEK AHIHIHVPEG ATPKDGPSAG VTLVSSLLSL ALNKPVVQNM AMTGEISLTG
KVLPVGGIKE KVIAARRVGA KRVFLPSENR RDYDDLPEFM KDDLDVRFVS EYSELYQDLF
E
//
