ID W2TAX6_NECAM Unreviewed; 321 AA.
AC W2TAX6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Eukaryotic aspartyl protease {ECO:0000313|EMBL:ETN78734.1};
GN ORFNames=NECAME_10172 {ECO:0000313|EMBL:ETN78734.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN78734.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; KI659771; ETN78734.1; -; Genomic_DNA.
DR RefSeq; XP_013300961.1; XM_013445507.1.
DR AlphaFoldDB; W2TAX6; -.
DR EnsemblMetazoa; NECAME_10172; NECAME_10172; NECAME_10172.
DR GeneID; 25350201; -.
DR KEGG; nai:NECAME_10172; -.
DR CTD; 25350201; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF45; ASPARTIC PROTEASE 6; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ETN78734.1};
KW Protease {ECO:0000313|EMBL:ETN78734.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 1..321
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
SQ SEQUENCE 321 AA; 36461 MW; B4553423CD99E632 CRC64;
MREDLCHEFG QCYTDMKEQI RNQSDNIYSM KEMACRVFCP EISCCEQKKI LNEEEYSCKG
KHIFNSKKSN TYVPTEGSWS DAYGNGEAEG FYGNDTVRFG GIGTNQLIVP GAHFGQAELI
TGYFTEHPID GVFGLGFPIL CTEEVVTPFQ RAYDLQLIDP VFTVFLKHAN EIEEDKFGGM
FTFGGVDEEH CEKAITYETL TEAAYWKFKM ANISCGSFSA KNEWSATTHT GDLFISGPWR
IISEMAKQYN AVYDEDMDIF VIDCNAQPRM EIGIGSHKYT IRSSNLIIKV KEDYCIFALR
SHETGEKLNR GIRCLNSKNL Q
//
