ID W2TH25_NECAM Unreviewed; 141 AA.
AC W2TH25;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
DE Flags: Fragment;
GN ORFNames=NECAME_08571 {ECO:0000313|EMBL:ETN81350.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81350.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the battenin family.
CC {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361113}.
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DR EMBL; KI658757; ETN81350.1; -; Genomic_DNA.
DR RefSeq; XP_013303577.1; XM_013448123.1.
DR AlphaFoldDB; W2TH25; -.
DR STRING; 51031.W2TH25; -.
DR EnsemblMetazoa; NECAME_08571; NECAME_08571; NECAME_08571.
DR GeneID; 25348600; -.
DR KEGG; nai:NECAME_08571; -.
DR CTD; 25348600; -.
DR OMA; SYANTFD; -.
DR OrthoDB; 2912995at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; BATTENIN; 1.
DR PANTHER; PTHR10981:SF8; BATTENIN; 1.
DR Pfam; PF02487; CLN3; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU361113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361113}.
FT TRANSMEM 42..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 69..95
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN81350.1"
FT NON_TER 141
FT /evidence="ECO:0000313|EMBL:ETN81350.1"
SQ SEQUENCE 141 AA; 15828 MW; 2AF8C1A20A0EAC76 CRC64;
GGSLSYQLPG SLRFSPFLRV RKENFQVLYQ FGVFLSRSSV KLFALPTWSL YLLPVLQASN
FFFFFFEAIY WFVPSIGIIF GLIVFEGLLG GAAYVNTFDK IHKMVPPDVR EYSLSVATVG
DSIGINFAGF MSIPLHNFIC G
//
