ID W2TI60_NECAM Unreviewed; 519 AA.
AC W2TI60;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
DE Flags: Fragment;
GN ORFNames=NECAME_08481 {ECO:0000313|EMBL:ETN81513.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81513.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000256|ARBA:ARBA00006416}.
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DR EMBL; KI658717; ETN81513.1; -; Genomic_DNA.
DR RefSeq; XP_013303740.1; XM_013448286.1.
DR AlphaFoldDB; W2TI60; -.
DR EnsemblMetazoa; NECAME_08481; NECAME_08481; NECAME_08481.
DR GeneID; 25348510; -.
DR KEGG; nai:NECAME_08481; -.
DR CTD; 25348510; -.
DR OrthoDB; 590256at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR005336; MPC.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF588; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE GLR-3; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF03650; MPC; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Ion transport {ECO:0000256|ARBA:ARBA00023286};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 460..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..495
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
FT NON_TER 519
FT /evidence="ECO:0000313|EMBL:ETN81513.1"
SQ SEQUENCE 519 AA; 58417 MW; 0F13E74985AFC35C CRC64;
MFFLSQLDPA RESAYVKPAR MAPHRVLYNA LCKVGDRVVY PVLPSFAKPA WNHPAGPKTV
FFWAPTIKWA LIAAGLADLA RPANKLSVSQ NSALCATGAI WTRYCLVITP AMHMQKFNKF
SRTIRAGDNS EKNLAVRFRM DRVQIPTEFI DLTRIISASN FGKPYRCHLV KLPSDVRPGL
KHVKNTYANP RFVVHMALGK IPPLLAAAAE FGLCGTMNHY VMLHWDTLLL DPINTSTTEN
CNITTFSLFD RDFLPSNLRK TTLLDAVWKD TLSVLNSSLS TVHYNGRPKC EMSWIDGAAI
TKAMFDVNTT GITGRITVNH WGTRTNFTIH INKKKGRQLH KYAEWSSSSG QITTPNAMEA
KSSLPLSQRE TLENKTLKVS VYLDKFQGFL AGLRVPSGDD RILSQISPFE KLERNNETGH
WDKVDNQFSF RNACWFTVSS LMQQGCELSP RAPSTRVATA VWWFFALILI SSYTANLAAF
LTTQRMDSKI DTYERMWKLM SSNPSLFVSS SKEGIARVK
//
