ID   W2TME5_NECAM            Unreviewed;       427 AA.
AC   W2TME5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Phorbol esters/diacylglycerol binding domain protein {ECO:0000313|EMBL:ETN82938.1};
GN   ORFNames=NECAME_07652 {ECO:0000313|EMBL:ETN82938.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN82938.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR   EMBL; KI658332; ETN82938.1; -; Genomic_DNA.
DR   RefSeq; XP_013305165.1; XM_013449711.1.
DR   AlphaFoldDB; W2TME5; -.
DR   STRING; 51031.W2TME5; -.
DR   EnsemblMetazoa; NECAME_07652; NECAME_07652; NECAME_07652.
DR   GeneID; 25347682; -.
DR   KEGG; nai:NECAME_07652; -.
DR   CTD; 25347682; -.
DR   OMA; RECEEEP; -.
DR   OrthoDB; 2939922at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0004697; F:diacylglycerol-dependent serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd20795; C1_PKD_rpt1; 1.
DR   CDD; cd20796; C1_PKD_rpt2; 1.
DR   CDD; cd01239; PH_PKD; 1.
DR   Gene3D; 3.30.60.20; -; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22968; PROTEIN KINASE C, MU; 1.
DR   PANTHER; PTHR22968:SF24; SERINE_THREONINE-PROTEIN KINASE; 1.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          42..92
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          195..245
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          256..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..276
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  48776 MW;  92728D517945A16E CRC64;
     MGRITREKPS FMLVGCHEYR NLQEESKPTR TCPQHERLVV HPHTLYVHSY KAPTFCDFCG
     ELLFGLVKQG LKCQGCGLNY HKRCASKIPN NCNGSRQRRP SAIPLSPTTS NVLNFCGDRR
     QSRRDSCLDG LDTARPSSTI GSIQLAPDIF ITPDADCGDP VGGNFLQMPR KDRSCSWSGR
     PLWMEVAEAT RVKVPHTFQV HSYKRPTVCQ YCKKLLKGLI RQGIQCRDCK YNCHKKCSEF
     VAKDCPGNTS SNHFLLGTSD DGTTEDHGDD LRGHKKAQNT PSAPLHGSEN FNGQSSPDDD
     VISTESQNIP LMRVVMSKKQ TKRKSNKVLK EGWVVHYTNQ MNMRKKHYWR LDTKSLIMYQ
     DETSTRYFKE IPLNEVLDLK NIDHDTLKRS RTHYFEIRTQ DCTYYIETDK GAQEQAIRVP
     TNSITNY
//