ID W2TTE5_NECAM Unreviewed; 342 AA.
AC W2TTE5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Glycosyltransferase family 28 protein {ECO:0000313|EMBL:ETN85063.1};
GN ORFNames=NECAME_06610 {ECO:0000313|EMBL:ETN85063.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN85063.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; KI657822; ETN85063.1; -; Genomic_DNA.
DR RefSeq; XP_013307290.1; XM_013451836.1.
DR AlphaFoldDB; W2TTE5; -.
DR STRING; 51031.W2TTE5; -.
DR EnsemblMetazoa; NECAME_06610; NECAME_06610; NECAME_06610.
DR GeneID; 25346642; -.
DR KEGG; nai:NECAME_06610; -.
DR CTD; 25346642; -.
DR OrthoDB; 382054at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF162; UDP-GLYCOSYLTRANSFERASE FAMILY 305 MEMBER A1, ISOFORM A-RELATED; 1.
DR Pfam; PF00201; UDPGT; 2.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETN85063.1}.
SQ SEQUENCE 342 AA; 39449 MW; 2D65E7FA653C3A64 CRC64;
MNEQVLTYCK DLLEDTELLN SLNESKFELV YTEANDICAP GIFQILGIKN VVLAVAHTMM
PRMYEVTGMS TLPSFMPEIV TPFSDDMTFV ERMANFKISM QFMFHMRKWE RIFWEHFNAK
YPGFPAIREI YNEKTALIMT NVHEFAESPR PTTNMIRYIG GSTLYEAKPL EKDLDDLLNE
REATVLFSLG SVAKSKNMPE WLRNADKRLS LFITHGGMNS MLEAMHYGKP VIVIPLFGDQ
LHNSRNIPRL QIGNILDRTR ISQKTLTEMI KKTLGNETIL RNAAFVASQL AGRPQQYRED
IARWAKVILE YGRMDHLILH SRNMNSIHIV AFKTGILLYK SL
//
