ID W2TZV0_NECAM Unreviewed; 499 AA.
AC W2TZV0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Elongation factor Tu, mitochondrial {ECO:0000256|ARBA:ARBA00017898};
DE Flags: Fragment;
GN ORFNames=NECAME_05910 {ECO:0000313|EMBL:ETN86606.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN86606.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR EMBL; KI657524; ETN86606.1; -; Genomic_DNA.
DR RefSeq; XP_013308833.1; XM_013453379.1.
DR AlphaFoldDB; W2TZV0; -.
DR STRING; 51031.W2TZV0; -.
DR EnsemblMetazoa; NECAME_05910; NECAME_05910; NECAME_05910.
DR GeneID; 25345942; -.
DR KEGG; nai:NECAME_05910; -.
DR CTD; 25345942; -.
DR OMA; FHNNYRP; -.
DR OrthoDB; 167272at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01884; EF_Tu; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR041709; EF-Tu_GTP-bd.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:ETN86606.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|EMBL:ETN86606.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 37..235
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 476..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN86606.1"
SQ SEQUENCE 499 AA; 55321 MW; FDFA3F69205992B5 CRC64;
TVFGSSLGER VVSKVLRSQQ VRCLAVPGGK EVFKRNKPHL NVGTIGHVDH GKTTLTSAIT
KVLATSKGAK FRKYEDIDNA PEEKARGITI NAFHLEYETA KRHYAHIDCP GHADYIKNMI
TGAAQMEGAI LVVAATDGAM PQTREHLLLA HQVGIPRENV AVYLNKVDEV PDQETRELVE
MEIRELLNEF EYPGDTAPVI FGSALCALEG KKPEIGEESI KQLLNVLDEK FVIPERNVNT
EAMFAAEHVY SIQGKLFFTN LTYMIILVGR GTVITGKLER GTLKRGDKIE IIGCDRENTK
SVISGLESFR KTVEQAEPGD QLGILLRGLG PKDVRRGCVL LPQGHKHKAT DKVKAQLYIL
KPSEGGSKVP LANYFSEHVF SLTWDTSALL KINGKDFVMP GEAAEVELRL SQKMFIEPQQ
RFTIRKGTTT VGTGVFTEVL PPQTEEEKNP KNKKKLMKAE MERLGFNPYG ELMEKRLKPD
YSNSPKDNPA AKAFEGAEA
//
