ID W2UFK7_9GAMM Unreviewed; 4285 AA.
AC W2UFK7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Calcium-dependent protease {ECO:0000313|EMBL:ETN92813.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:ETN92813.1};
GN Name=prcA {ECO:0000313|EMBL:ETN92813.1};
GN ORFNames=U062_00695 {ECO:0000313|EMBL:ETN92813.1};
OS Gammaproteobacteria bacterium MOLA455.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Porticoccaceae.
OX NCBI_TaxID=1411685 {ECO:0000313|EMBL:ETN92813.1, ECO:0000313|Proteomes:UP000018839};
RN [1] {ECO:0000313|EMBL:ETN92813.1, ECO:0000313|Proteomes:UP000018839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MOLA455 {ECO:0000313|EMBL:ETN92813.1,
RC ECO:0000313|Proteomes:UP000018839};
RX PubMed=24482511;
RA Courties A., Riedel T., Jarek M., Papadatou M., Intertaglia L., Lebaron P.,
RA Suzuki M.T.;
RT "Draft Genome Sequence of the Gammaproteobacterial Strain MOLA455, a
RT Representative of a Ubiquitous Proteorhodopsin-Producing Group in the
RT Ocean.";
RL Genome Announc. 2:e01203-e01213(2014).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETN92813.1}.
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DR EMBL; AZIN01000001; ETN92813.1; -; Genomic_DNA.
DR STRING; 1411685.U062_00695; -.
DR PATRIC; fig|1411685.3.peg.678; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG2931; Bacteria.
DR eggNOG; COG4935; Bacteria.
DR Proteomes; UP000018839; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd11304; Cadherin_repeat; 1.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.380; -; 8.
DR Gene3D; 2.60.40.60; Cadherins; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 10.
DR InterPro; IPR006644; Cadg.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR013858; Peptidase_M10B_C.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF05345; He_PIG; 1.
DR Pfam; PF00353; HemolysinCabind; 15.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF08548; Peptidase_M10_C; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00313; CABNDNGRPT.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00112; CA; 1.
DR SMART; SM00736; CADG; 1.
DR SUPFAM; SSF51120; beta-Roll; 9.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 10.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000018839};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 5..108
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3195..3337
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 2897
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 2940
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 3115
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 4285 AA; 452791 MW; A9B8FDD5D6A5CD84 CRC64;
MAIVFSSDSQ AKVNENIGQN RLIYTAIAAH DDDSSTELVY TLSADSPAEL SINASSGEVF
LSESPDYETQ SLYDFTVIAS DNNGQSSQHS ISLSVVDVLE GGAGDQTLIG GAGDDIVDGG
SGFNTFQVQG SADAFYWTVN SSGQVILNDA VVADDDPVDG GDEGTDTLTN IQAISYVAPD
GTVESSIVID DFSNAPDVTN RQIDYGESVN GRANFYGDID YFTLEVTEGT KVKISSGSST
EWGSYLNFED GGVYLGSNQV GDRTLSGSGL QDIWFTSGGL SNDAPMRSKS YSFVIRRVLE
GTDQDDTLEA GSSYEWLEGG VGNDSLIGSD RDDQLLGGAG NDVLTGGLGN DSLDGGAGDA
NIAHYTGNYA DYAVNFVATY DRDLKLSIRD SIDNRDGFDQ LANIQILRFA DRDLVLDAES
NSANFDAYSI GESITGTLPA ASQLWYLDQD YFQQKFTADI STDSALRIRF ETSPQSGNYT
NGRLTLRFLA MGSDDRLSFK NLETENSIIK FEVNTNQSAS WFVSPEYWGD SSEFLAMAQR
ADIKVDGYAY SDQAEFGDLI NYSISVDRVI FGTASDDTLV GDAQVGYIDA REGNDIITGS
DINEEIVGGD GDDTLSGGAG DDILRDGEGN DIIKGDAGDD LISITNMVNA PTATIDGGEG
TDTLQIDGGV SWDNLLVSNV EILDGRNGAS SLSVDALLDK GFVGAKNIEF RLDPNLAEGG
TVDVSKLSGN IDVRGTNQSD TLIGNDDNNQ IYLNASEQVG NGLGVDTVNA GAGDDSLIWK
IQQYQSWSAS FSSFDAGTKT YTLEGTYNGG LGSDKVTLDF NGSYFYHPSG NTWNQSDSFA
WKLDLTKLEL LDIETFEVIG YDSNRFWAHP SEFLLTIAQL DGLSSVSGLR SVGIVGGGTI
EMEHLNALGL ENWRIADDMA YTINGSANSE SINLGSGLMV VSAGEGSDGI TIDNKSLVLD
SIDGGDGTDA LTVRGADVDL SGAILTNLEE IRVSSQSLAM SESQWAEFGS LVKVISGATT
EFTLSLENAG TFTLDEETLF AGFSGSSGDD RLIGNSLDNI LTGNAGNDIL QGNAGDDTLI
GGSGVDEILG GTGDDQLNVS GKAVVSDRLV GGEGTDTLIV SDGQDLTGAT INGIEILSGA
GTVTMSAEQL KLLKKIQGVN VQLTGESSEF TMPSELQLLQ GAAIYLPAMD SELVGASGVV
GSAKDDIITG SGGADTLVGG RGADYLSGGD GNDTLIGGKG TDTLMGGSGD DTLIVGASAF
TQDSQTIGGD KVFGGSDYDL LQVDFNQSNY STYTIVDGSL SGIEALSILG TGGNAYQNTV
QLSADVWNSF EEVSLSDGNE WGAVKLSIKG TGEDLSFESV LSQTYAESIS LNGSFGSIDV
SNDPLVTKDE ERYKLELYGK FIDITLSDNA DRIEVYDDLN YQLAAGAGDD WIQHKRSGNL
VASIEGGTGS DTFDISNTGF IDLTQVTLTN VENVYHGETR IVLTEEQFSG WSLDGTGAVF
TKSDGVITGT AGDDYFDGQG QGAFEGGAGN DSLRSLHTAV FSGNLADYDR TRDGEAVFVE
HARGTLLDGN DTVRHVLNLQ FADTTVVLDD APDLVDSYLY QTNGNGDELI ASLTAIEYGK
QMSAKSDYRN DYDLFSATFA PNSPLAIEAS TVNGSGWQFE FWDVATNQQI QFKSLVYGWI
NYSFSNWMSA DQKWLPGFNT NDGFEAYQGG QVLVRAKVEA NDDYPIEDYA FTFNYLDDYA
GGVDTLGEID PQEGLIRGYI GDINDADWIR TDLIAGTKYE FRLQGQSSDA GTLVDPKLQL
LDSQGRVIEA GLDQANDVAG TDDAIVFRPT DSDTYYLAVT DVASINKGSW TLTQGSLDTI
AGNISTTERI EWSAANTFRA ESEINQLTDH DWFKVWLDKG LTYSFTMDGI SLGGTLSDPQ
LSLRSVTGRL LTQDDNSGSG SDAEIYFAAP DSGWYYLDAG ASGNASRGTY ILRGSSLTDD
YANSILTEGL VTLGEQASGL ISYIADSDWL QVGLSANTTY VIDLKGDISD GARLDPVRDP
LLIIRDASGN VIYRTDDFNG TLDARAYFTP DNDGLYFLEA RSAFKYDIGA YTIDVALAPE
DDHGSVLDET ATALVLGENY AVMSAGDIGI PGDKDVFKME FDGGKVYQLE ASGFAGFAGT
LVDPYIRVFN SNGQLLDFDN NGGSGTDAKF YFAPEDAGTY YIEVSSNNNR GMGTYEVSVS
QRNLPPDDVP NNLSTQVILN PGDSFNGNLL TKNDQDWFGI KLEAGEHYVF RAKASASGNG
SLEDPVLELR GTNGELLRSV DNMLAGNEPA LGFSVDDSGT YYLVVKAADG TVDTGTYTLI
TRAPDDHGNT QSDATVIALD ETLTGGIQWN DGSFGVRAFD SIGLATDFDE DWFVFTGVAE
QILSINVELA DGSMLSRPMV EVIDEQGRVM AFGDGLETDN GLAVATFRVP TDGTYYARVI
DGAGATGNYS VQLTTGDASD EDSEGPVSLS FSDNGAIKQS VTVATIGLSG DSDNFEAVLE
EGHSYRIETV AVRDSSVAPL PSAALTMKWL AADESEATDI SAGADLTNPS FFDSAEFTAL
TGGKLSLNVA PLEETQTGRY QLRIIDLGSQ ADDDLPNAVA DFNESEHGVL AINENIEGKI
DSAEDKDLIA VNLTQGNIYD FSVKGYFDGL GTLAEAELRL LNEVGQLVSV GSYDAVTGRT
EFSVSVFSDG RYFLEISAEE LPGNTGTYTL DTRLRGSDDN VIDDISADTQ SGVVVGPGKP
ATGEIETAGD HDWISVSLEA GKVYVLDILA DGDGSGGTLT DATLRLIDSN GDEVASDDNS
GAGKDARLQV TPGTSGDYYL DISSRFGEVG TYTARVRELY SGVADPLVTA QWYLEEAGIF
ELDGQYTGAG ITVGVVDDGI DTSHPDLQNN LNFSLAYDTQ FDTSDGQPKY PYLVGPPDNH
GTLVAGIIAA EANNETGIRG VAPDAELVST RVKWSWDQMI QALSLQWQFD VSNNSWGAIS
PFSDNFNSTS LTFGWVALRK GVEDGRDGLG TNFVFSAGNS AGAGDNTNYH NFQNAREVIT
VGAANADGTM ASFSTPGASV LVSSYGVGMI TTDRHQPGWG EAKSSDYYGG FSGTSASAPL
VSGIVAMMLE ANPNLGYRDV QKILAYSTTH PDGQDWKTNG ASDWNLGGLQ FNDKAGFGLV
DAYTAVQLAR TWTDTNTSIN EISASARKFG MVESIPDGDG SSYTMAFEVD SNLSVENVEL
GIDLRHQRLG DLIITLTSPN GTVSTLMDRA TVNSERPFGL SGQDSGVPTH LLWDFSSVQF
WGEQATGTWT ISVADVRPEQ IGTIQSLSLR IYGERQDGND TYIFTDEGFA NQTGSILEDE
FGEDTINASP VRFDTYIDLY QGIIAANATT HGIASWTIVE NAISGSGNDS LVGNSADNYL
DAGAGNDVLQ GSEGDDTLVG GAGRDTAYYV GLMAEYSVSW DPNTETVTVV DNKTSNGDDG
TDILSGIERI VFSDGELNLA ETTGNRPPVA NASVFDGTVQ LQSGMGIEYQ LPDDAFTDAD
GEAASEMEIA VSDAAGGELP EWLSYDPATG TFSGVPPADF QGIIKLKVEA IDEYGVSTSD
ILTLQFGDNQ APTLENPKEV VVSEDQGLVS LEFTAPTDPE GGEVSIEITE IPSLGVLIDK
SGNQVSVGAV FSADEFTELF YQTGEDANGD AGYVRYKASD EDGVVSESSA HIFVDAVNDA
PRFSTKSSKL IIDYPEQTTV ALDILEPVDP ESVLTTVRVS ELPQLGIISL DDQVVSIDQV
LTFDQLNRLT FTLDENVNGP IGAITIQAVD DEGAATNWSL QLEVQGDAEF NSGTVGDDEL
YGSIADDILY GKGGNDTLVG NAGDDRLLGG LGNDSVIGGS GDDKLDGSAG NDYLDGGSGA
DFMTGGPGSD TYIVDSAGDV ALEVISGGSG GKDVIVTSIS LIAPENIENL QASAGDAINL
TGNELDNVLL GNDENNVLQG RDGRDTLFGE AGEDTLDGGS GVDLLAGGLG DDTYNVSSKS
DRVVEQVGQG VDHVIAASSY TLSSNVENLT LEEGGNFTAG GNSLDNHLIG NAGNNILAGG
IGADILEGGL GDDIYVLSDS MDTIIDLGGE DTIRSNLDIV LINDIENADL VGIADTMAIG
NGLANNLIGN MADNILDGAG GIDTLTGGEG ADTFVIANNG EGVDADLITD FTSGEDLIVL
DLASYGVSAE ELGLLSSGLV SAESFVIGAG AKALDSNDHF IFDSAQGLLQ FDVDGSGDEE
TMVIAHINLD EDSARITSGD VFVGI
//
