ID W2WJR1_PHYPR Unreviewed; 5307 AA.
AC W2WJR1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=F441_14009 {ECO:0000313|EMBL:ETP10363.1};
OS Phytophthora parasitica CJ01A1.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317063 {ECO:0000313|EMBL:ETP10363.1, ECO:0000313|Proteomes:UP000018958};
RN [1] {ECO:0000313|EMBL:ETP10363.1, ECO:0000313|Proteomes:UP000018958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ01A1 {ECO:0000313|EMBL:ETP10363.1,
RC ECO:0000313|Proteomes:UP000018958};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ01A1.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP10363.1}.
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DR EMBL; ANIX01002773; ETP10363.1; -; Genomic_DNA.
DR EnsemblProtists; ETP10363; ETP10363; F441_14009.
DR Proteomes; UP000018958; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00060; FHA; 1.
DR CDD; cd11709; SPRY; 2.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR009291; Vps62.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 6.
DR Pfam; PF00622; SPRY; 3.
DR Pfam; PF06101; Vps62; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 6.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 953..1151
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 1710..1764
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1765..1818
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1819..1870
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1871..1925
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1926..1977
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1978..2033
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 2820..2876
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 3993..4198
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 4359..4546
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 4600..4631
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 4916..5270
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 2434..2472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2756..2779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2959..2979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3000..3038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3054..3122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3239..3303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4550..4584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4663..4712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2435..2462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3015..3038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3054..3073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3087..3122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3240..3267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4567..4581
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4696..4712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 5233
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 5307 AA; 579031 MW; EF743FCBD67FD828 CRC64;
MLFTIADYVP KTTMSGEVLW FYHAVKQETA LAIYHGFPTL FPSLLDRLQI MNRLMVNKPN
FEAELTPAQK LLIPKLVPCF TSAKMLFQLI SDPNVLFKVD GLSDDVVSES VITFMGTLLD
SLWVQTKDAM ERCAEDTTKL MKSFDAIETS HEFNCLNIML RAAIFWCSCS TSRGWVIIES
VCTKVVDFVS ECLNQCSTMK HDQNQLLPVV IQRSFSGKLL PFMLLSVFSL PSVRDALPGL
LDPFWPRLEA LSVKLHIALA TLSKQGHLQP TTVAVDTRTA LGSNAETDFV DTALASMSKE
LSTCLLNQST GSSVTYGQIF KNLWDKIVHA KGYTSRKVKE LPQDVEIRRV TIPLDLAKLF
GTETLLVKVQ TAGSGPVLEY EPRKVSFLPS RTILSQHLYP VSENALPAPG DEATVGLPLA
PQSLIESSLP SAQYSDKAIE DSHEWLKDLQ KVIVWVGSHY AATLILGGEL DGGVVSEKWL
QASLFRGGLD ETWPATDTTR SEVGRNETLL LQVIENVGNG KKLLDKVRNA LDPGSAPGGG
NPQFRIARLK RQDSVEAQLE KSGSIEAVDR AVRATFAALL KHTNISYTTE PISNQGTLAE
TVVDAWKAAL QLRRWIVREQ QKLAAAVSEA GAPSGISPDM GVKERQQALY NAVCEPIIRR
ALLLLQLSPV PIQFTPPASS PMRLLPGISM ATTYDFAKSS QTEPAATPDK EPEQKRFTRQ
LNKLMETKSV EVMEEEDEQI HADIFSFIQQ SSTNLVVPTR DSEVPSRHPE DQMREILLAH
QKRAKMRLQG LKTFVRLLQC TENIPSSRLH VIPMLSSAFK RVRTTHGKMS GQISTIKVHY
LVDLEFAGQQ LSHTIGQEFF HLLTILLESS MDHLRQVQQL IDAGSGEISD TKTAGASIHL
AVNDMLLVLE TCCFPYKGQD WDHLQRTNLV SLLTDLTSWK GWQTFIQYDA SDNSTTDVDS
TEKYTILSAA TGSKYPNIIC SRYITLGSDL RKLTIAHKSL DRSDLGTGSS SVSQDNGGLA
VFDKNFYRGR WYWEVSIRDL GDTPVFVGVT PGTTDLNAYI PGDASLCGVL LYREGYSGGM
LGSAGIRWNR NDVLGVLLNS EERQLEFYNG ANRCYVATLT PSDLAGCGYF PAIGVSGADV
HWNLMATVPP KLWCASSNFQ FSNSIVTRGL VATPFDGATI SWNGKHKGGR LQLMPNGTTV
CAGDCSSSDD QFETIVASQG FENESIFAEI RVIAAGKNGR AALSFCIVDN DFSAFDSPLK
QTLDVKWKSA EEVLELGILG VLFDFEKATA TLYSDRSEPE VCQFNLASLN KPFYPAVSAL
CNGTVFDVNF HSQPRLELPS HVFYPATKLQ NQLMSSSNEL QLGKSLQLQL LSCDGGEFSS
SHAACNCLVD DTTVYSSAKG TNVNLVLKHE IDTPMCVSYV NIRGPGQGYS SPLRYAVVFV
TSTPPELASF QEFDNMTPEQ FAALPFPPSN GCCPRDESLP VAFVVLDGSC AQISKQLAYP
VAGRYIIVKA ICPSAGTNID IGYIAFCGIF DRDNGPAYSE TTAVSYSCEE CKRMPLSGIH
YGQQDDDGIR LCAACYDDNR GDLDCAYNVY TCSESEEDQI AANTVLCPPR RSWNDKIAAL
SDVFSKSTMS NAARDRNTAA GQTGRSESLL SVASFEECEL FSCGQNNYGE LCLGHCNSTS
KLEHVPFFSA KGIRDIAGGN EVLAVVTTDG TVFTCGLNKS GQCGNGTFEE RVIIATPVRA
LSGITINMVA AANGCEHMLA VASDGAVFSW GYNDRGQLGL GSTISKSHTP RMIDSLREKY
HITTAAVSYH HSAVVSSNGE LLTFGMNDCG QLGLDHTQHQ HTPQLVEALS SQVVTKVACG
LYHTIAVTSG GEVYSFGKND YGQLALGHAR NMKAPTLVKT SLGESDEKIV AVSCGYYHTV
TISEKGKLIT WGRNDYGQLG IGSKEHKNSA QFVPLPLSSK IKTASCGCYH TLILMANGRV
MVFGRNNKGQ LGAGSRTLPS ADLPLPVPSN SLANDEVVRI AAGFYSSYIL TGRSGDSPGL
DGTPDDANQA KDLPENSCLA NSDALFESLM KEIDSKYVTD AAPKRASLQH KRGYPQRKLP
LVKLHAAGWA MARALMYRSL QDADDKISNR LSGRVNPVLA MFISFLLENL KLLQGDTSTV
EALTTTGTHE LGGSVSLKRV CVGLLQYFGG KFAVPTPTAG PVGLTLDNLH GHLYRNQILS
VLLACGSANT KVGSTIAANP VVTAHIISGM SSSDLASATM CIRLAMLVFP HHSVSALNTI
YRSQQSAPVF SGDILSMLMT LVGLPMLLRP RLCSHELGLE CSSTALCQSA CCLKGITVTK
DSGISHMQQV VLEKAHVADS KAAEVVALLR YLTFYPTWKV AINAAITRGF AKSNKVGELL
DAICAYYTNV QQANIADLKA AVLGGLAGEK NATALRKPES TSLSPETDEP VNNTVESNTQ
SDESESTSRD KQSLMLWQKA KDALNGLATI IAAVSIVGGH VEGFREGGCV TIEDDGTQGS
SRLGVLSGVM RDPRTADLLA KVVVSSSTEG PVSPLIAADA RAQSFPLSKL QVVERIPALV
DMFGDVDSII TTLSSIVSEV LTVDKECATH CDIDLPQNSS VQEVLRNRLK VYKQQIRWRS
AKALSSLLKQ IPTLSPTLIS MDSQLISSLA TLLSSENSLS WVSKSEIPGL ETATALQKRW
ICVKQRKVFL DTEDVIDTAL DYYEAKMRNE VVQKLGSENA LSWGMDAIQS PRRKVTHPSF
AGSGFGENGR AKQRSTDGDL PFGTWGVLLP LPPLNENEHT VGPGSSAIDY TPFPLTAPII
RVGRAADACD LIVNDRSVSG RHFHLRRLRR EAEGGETQFE LQDFSKNGTV VNGVRIHGST
TRITSGSRIS LILSRGGLVT YEFQVRTSGG NTGSRNAPPH IVTAPQNSGD LNISIPGQEY
QQPQAGTSQI VPRSPAELQN RGIRGSSIPT EVPADNRSRQ AVTQGLRVIT SVAESDVPRA
LLSPNPAVDS PRAGGYSSPR SSVLQAPGTP SVGPLTPSMF SSMIPPAILS PASYQQRESV
APNENTGLTS PQGGVGSMLR IALGRDSVNR ESSSQRSGIP SELAKTRVLR SSGQTGLAAR
SNATPAQEMQ VLTLRLLART QEANLVVSAT ECEEALQVAA GNMDEAFATI QRSRGSNPRM
YPSSVRHLAM VLGRSEPVCS EALRQTDGSF GDALRLLMST RKIDLEKTLS PRYVDADVLN
DGNLQSSEPL ENLQDLGDEN PSYALTESSA LRPPVPPRLA ARGNGSPVKT KKMEHTGNMD
TLQPKSDLTL WSECNSSFDE GVRQMNSFEV EVEEEVLCER LAAIHARKIL LQIVRLYTHA
SQTEEAPLSE LTNPLVLRSL ISILSVPEQA NASSSYELEY QLHQQPKAKK SGKIQQILSR
MAHDMMARSP TETLAKNFSS SQNLSTLQRS IDQVTEQPTK IGWTGITRLI ESLVENEQVR
GEDVNDQDPL NTLENITFET ILHILSRTYA TPMTAPSWDS SPLRTRKADG CFPKGPMRLS
CGLEVVVVDT YERLWSIPPP DPLLKHRHKW RKRFSSTAEN GWMKSAADYA VTIWRPILPP
AMESASSASK WFCLGDVAKC SNGAPNAPML LVSDGDNQGL LVPPVSFERV DITGKGLPRN
SESDPDFQRK QLRSIWWPVA PSGYVSLGCI AGSKEDPFEP PDVSSTRCVR EDIVKRVEGF
HCVWRADSPA ATGGGGVELL TTIEVENDEE NAGGESDAQR NHSTKNQSTD ASRLQLLLPV
ADDVVVQTSL WAVDSDFSCG LLLPVVTLND ASANEPSTAF ALNLSDDDLV LCAPVSVDNV
LVFLEILLQY QQLLSSKQED KQRMSTQLRS ELPAALFALI QQVLRENQPS SGKAAVSLVR
ALITVIQRGA HWYDKQALLY CRSKIMALSQ DQDGGFTLHA LLQAFVELML AVEDQQHTQR
VQELAACLDR DSGNALSLPY RFHFAKQPFV EMLVSHSSKM AVTRHLSGEE RKFLLDYHAE
DSSNRDALAV EGLGAPPGEV YSCRFEHTPA LVMTMRDEVK AELVYFEVGV MEWSTNSSMG
GSLALGFSPP SFPLEGVLVG GSADGSRSYS FAPASGQVLC AGDTAVDRWR WIEPVGAVSP
GDVFGCGLRL DTQEIFFCKN GQLLGTAFSS ISRPQQLHPT ISFNADCKLL ANLGATTATP
AKHANFSFRF HSLDCDNLMS AFEWFEPLSQ VYGVMKALMD PERPDDVNVS DGPTDESTDA
AVVAQLPDEF MLSADNFLSD ISEDVCIRVE SAHPYDLELQ ESLVSIPLAT SIRVRLDPQS
ETASSHCLQI LQGGSTEGEC TTTGEAEVRA FTGVCGSQEV TIDGDSFVWR FPVQSNFQCR
VDRVRKGPYL KLEARDTRLS LVRDKGWQTA IGVARFDGGI HIWEVRISFV TASSNIFLGI
GRRDVRLDSY LGKDNRGWGW IGNRALWHNG SKQRGTYGDK FKTGDIVRLT LDLRRGTLSY
ALNGKDLGVA FGPGGTGPKL EGTFYPAFAL YNQRDSIDLI GGHRVEDGGL EPGLSRTGSG
LASGDDSYYS EEEEEDLGGL VSDEGDGSIP NFRMELAIAL SQMGFPMEWC LYALRHCEDD
AEQAADYILA NMHAIESLVR EENETMARRT RHRQLLHEQA LALSERDGLD TSLPPPPPID
EDIDGVRPPE DVASTGDESP PQQQQSTGDT KWGMAFTAVP EFSVTGRRLL ATKYGPKLHR
LHASQRVFTP ARDRALVQLV NAICESRAEA LLSCDPLRMT PEEFVPTEEQ IHRFQSLRGV
SLEALQRRFL VLRNFNCRLQ TSLAFIDFSA ADERSLLARG ARELRGVVFQ HVKLAWWLGV
LKEQQAPAAA RPEIEVDRHR AHEALELSER GDPLASEVGE RDSVFAQTFE QLHGLQPALL
RGADRAFKCQ FVGEFGDDFG GLYRECLAQL SSELQTFTPL LPVLRPCPNA LMSTGENREL
FVPNSHLRTH PRRVQMAEFL GKLAGVAVRT KTPLDLNLPP AVWKLLVGQR VTRHDIEAIH
QGCFQVVDTI ASLDAHGITE EMFDDLVDAN FTVLSSTRET VELVPGGKHL HVTWGDREEY
ASAVETYRLT EFAPVCGDIS RGVGTILPAP TLGIFSWHEL RTLICGKPTV DIVLLRRRTI
YGDGCQATDP HIAYFWDVLA EFTDEQKSSF LRFVWGRSRL PTHAADFTQD FKISGLPKAT
GRADMYLPIA HTCFFSIDLP AYSCREVMRD KLVYAITHCQ SIDADNTTVA QRAGQGINWT
NTAATATATA SAAVSGVIAG VTSGTGE
//
