ID W2Y655_PHYPR Unreviewed; 869 AA.
AC W2Y655;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=F442_20438 {ECO:0000313|EMBL:ETP30595.1};
OS Phytophthora parasitica P10297.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP30595.1, ECO:0000313|Proteomes:UP000018948};
RN [1] {ECO:0000313|EMBL:ETP30595.1, ECO:0000313|Proteomes:UP000018948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P10297 {ECO:0000313|EMBL:ETP30595.1,
RC ECO:0000313|Proteomes:UP000018948};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P10297.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP30595.1}.
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DR EMBL; ANIY01004255; ETP30595.1; -; Genomic_DNA.
DR AlphaFoldDB; W2Y655; -.
DR EnsemblProtists; ETP30595; ETP30595; F442_20438.
DR Proteomes; UP000018948; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000018948};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 428..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 473..491
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 571..589
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 601..624
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 683..702
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 803..828
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 99..133
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 869 AA; 99055 MW; 04E3F1F46331DAFF CRC64;
MKWLRSAEME YISLIVNEDA AHDCVQKLGD LGVLEFTDLN PELTPFQRRY VNYVKRCDEM
ERKLRYFEVE LAKFSISPKP AGSIDQFLAG SADIRYGSQD TAARALDTLE RLLEDKEQEL
LQLNSMHEKL TREYNERKEL QEIISRAGEF FEIEIPEVQA RRNSRTASRS GYSFVETSPG
TAAGEESSSL RFRNVTGVVP ADERLKFERM IFRTTRGNCF TRFSPIEEPL VDPTNGQPVT
KHAFVIFFQS TFIENKLRKI CDAFHARLYS LPPMDDRAAI AHLIQSNAGE LNQSSHILRR
NRESCVLLCR DLAETLESWK WSVLQEKATY HALNMFRADV SGMLRAEGWV IKEALPSVRR
AVTRAHAAAD DKSMPSLVDT VPKPWPVPPT YFETNKFTDA FQAFVETYGC PRYREVNPSV
FTAVTFPFLF GVMYGDIGHG LCVLLFGLYL ILTERKLEQP GSMGEMTASI YGGRYMLFMM
GAFAIYAGLI YNDFFSLPLN LFGSKFAYPD CLESHDREAK CEAQYMIDGK MTYVNATDVS
AGDNVYAMGL DPVWKTSSNE LLFFNSFKMK ISVIFGIVQM TFGIFLKGWN NLYFRDYSTF
FFEFVPQIVF AVSLFCYMIV LIVMKWSIDW TERMKHEVCP YNFAGEHTGC RPPSLVNTLI
NIALAPTNVV DPLYEGQLET QQTLLMMAFV SVPAMLLVKP IYLKIQNDRT APPVSHHVDF
DDEAEERLVS HHHGNSSGGH GHGEEFEFGE VVIHQGIETI EFVLGMVSNT ASYLRLWALS
LAHSELATVF WEKTMLSTIN SDSFIAIFIG FAVFAATTFG VILAMDVLEC FLHALRLHWV
EFQNKFYKAD GHKFHPFSFK QTIKDSQQL
//
