ID W4EGD8_9BACL Unreviewed; 688 AA.
AC W4EGD8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:ETT78926.1};
GN ORFNames=C173_02379 {ECO:0000313|EMBL:ETT78926.1};
OS Paenibacillus sp. FSL R7-277.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1227352 {ECO:0000313|EMBL:ETT78926.1, ECO:0000313|Proteomes:UP000019051};
RN [1] {ECO:0000313|EMBL:ETT78926.1, ECO:0000313|Proteomes:UP000019051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL R7-277 {ECO:0000313|EMBL:ETT78926.1,
RC ECO:0000313|Proteomes:UP000019051};
RX PubMed=24422886; DOI=10.1186/1471-2164-15-26;
RA Moreno Switt A.I., Andrus A.D., Ranieri M.L., Orsi R.H., Ivy R.,
RA den Bakker H.C., Martin N.H., Wiedmann M., Boor K.J.;
RT "Genomic comparison of sporeforming bacilli isolated from milk.";
RL BMC Genomics 15:26-26(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETT78926.1}.
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DR EMBL; ASPX01000005; ETT78926.1; -; Genomic_DNA.
DR RefSeq; WP_036722045.1; NZ_ASPX01000005.1.
DR AlphaFoldDB; W4EGD8; -.
DR PATRIC; fig|1227352.4.peg.468; -.
DR eggNOG; COG0768; Bacteria.
DR Proteomes; UP000019051; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:ETT78926.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..278
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 333..666
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 688 AA; 75817 MW; 91018D1176DBD2F8 CRC64;
MRWFGKPGSG PGDGETRNYL SLRINLFFFG TFFIFVIIMI RLAGLQFVES PELSEVEASR
ETKDVPLAAI RGTIHAAGGE DIAHSTPIQS LFVTLTQEYT AKVKNKNTGL YEPTAEAKEN
TKALVAGLSS VFEQYGDPSA KKLLKEDILQ LLDLDYKKSL GYVPRKIKAG LTMKEVAHLM
ENRQRYPGVS VVEESIRHYD KDTVAVQTVG YMKQFRSTET GYNLYKNIRS AMKQTGADPG
LSYREDEFVG IYGLEQQYQR ELRGKNGYQT ISVNAQNMAE EVIALVPPVK GNDIWMTINK
QVQMSTEQAI MDQLNWLHRN PVQGKLHKDA LTGYAVAMEV DTGNVVAMAN MPDYDTNVWN
AERLPPEEWA KIEDYYQNGT ITDISSGISG NGLKSLIFLG STIKPLSVLI GLEEGLFTTG
DTYVDKGIGY FGKDNSSSVR NSSGHVLGPL SPAKAIQESS NAFMVEWVGN ALYKKYPGEG
IAIWDKYMKA FGLGVSTQSG LPGESPGVAD YLDPKKAGSA QAALVYASFG QKGKYTALQL
AQYTATLANE GVRIKPQLVS KITDPDGKTV KQFGREVLDS ITFHPSYWKE IKRGMNTKVK
AFDGFPYDFA RKTGTSEMEA FGAIRDNGVF IAYAPREQPK LAVAVIIPEG GFGANSAAPV
ARRIFEAYDQ EYGLDGVPKK NVPESRVD
//
