ID   W4F110_9BACL            Unreviewed;       710 AA.
AC   W4F110;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Penicillin-binding protein 2B (PBP-2B) {ECO:0000313|EMBL:ETT85766.1};
GN   ORFNames=C176_10057 {ECO:0000313|EMBL:ETT85766.1};
OS   Viridibacillus arenosi FSL R5-213.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Viridibacillus.
OX   NCBI_TaxID=1227360 {ECO:0000313|EMBL:ETT85766.1, ECO:0000313|Proteomes:UP000019062};
RN   [1] {ECO:0000313|EMBL:ETT85766.1, ECO:0000313|Proteomes:UP000019062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSL R5-213 {ECO:0000313|EMBL:ETT85766.1,
RC   ECO:0000313|Proteomes:UP000019062};
RX   PubMed=24422886; DOI=10.1186/1471-2164-15-26;
RA   Moreno Switt A.I., Andrus A.D., Ranieri M.L., Orsi R.H., Ivy R.,
RA   den Bakker H.C., Martin N.H., Wiedmann M., Boor K.J.;
RT   "Genomic comparison of sporeforming bacilli isolated from milk.";
RL   BMC Genomics 15:26-26(2014).
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETT85766.1}.
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DR   EMBL; ASQA01000016; ETT85766.1; -; Genomic_DNA.
DR   RefSeq; WP_038183837.1; NZ_ASQA01000016.1.
DR   AlphaFoldDB; W4F110; -.
DR   PATRIC; fig|1227360.4.peg.2049; -.
DR   eggNOG; COG0768; Bacteria.
DR   Proteomes; UP000019062; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR   CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR   Gene3D; 2.20.70.70; -; 1.
DR   Gene3D; 3.30.70.2110; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005543; PASTA_dom.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03793; PASTA; 2.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SMART; SM00740; PASTA; 2.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR   PROSITE; PS51178; PASTA; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019062};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          588..647
FT                   /note="PASTA"
FT                   /evidence="ECO:0000259|PROSITE:PS51178"
FT   DOMAIN          648..704
FT                   /note="PASTA"
FT                   /evidence="ECO:0000259|PROSITE:PS51178"
SQ   SEQUENCE   710 AA;  78304 MW;  62CA06143559AFC4 CRC64;
     MLIVYGGLFF AMFFRIFGIQ ASGQVEGQAL AAKAAAKYER SKVITANRGN ILDRQGQVIA
     EDTINYRLVA VISPKASEGT KTLMHVADKE KTAKILAKYL SISEKDIFDK LNTKVKNAQG
     NEIRQVEFGA AGRNISHGVM EQISSEKLPG IIFMEETKRF YPNGIFASNL IGLAQRDTQQ
     DGQTKTVGKM GLESIYNKEL SGTDGRVQYK SDVWGYLLPN SNKMVEPAKD GADVYLTIDK
     TIQNFLEDSM SKVYKKYNPE SMVAVVANPK TGEILAVSQR PTYNPQDGTG LENSWLNQLT
     ELTIEPGSTM KTFTLAAAVE EDKWFPNATF QSGQYTVLDR TIRDSNQVGW GSISYLEGIQ
     RSSNVGMAHL LKLMGDDTFI SYMKKFGFGE KTGIDLPNEA TGQILDKYPI NRVTTTYGQG
     STVTPIQLIQ AVSAIANDGK MMQPYVIEKI VNPNTKKIVK ENTPTIKGQP ISEKTAKEVR
     KILASTIYSE KGTGQNFASK EYEVAGKTGT AQIPKASGGY YWGKNEFLYS FLGMAPADDP
     QLVMYIAVEK PKLGPTDVGS EPTSTVFNTV MGSSLKYLNI KPQKIKKTKS QTMENLKGQL
     VEDVEKEFEE NGIETVIIGN GDKITDQYPA EKSEVLSGGF VFLKTDGDSV VPDFTDWSLR
     NVLTYQTMAG ANIEINGEGY VQKQSVKAGT VLNANKKIIL KMKKPEEIYK
//