ID W4HMG3_9RHOB Unreviewed; 792 AA.
AC W4HMG3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=ATO8_03566 {ECO:0000313|EMBL:ETW13937.1};
OS Roseivivax marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseivivax.
OX NCBI_TaxID=1379903 {ECO:0000313|EMBL:ETW13937.1, ECO:0000313|Proteomes:UP000019063};
RN [1] {ECO:0000313|EMBL:ETW13937.1, ECO:0000313|Proteomes:UP000019063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=22II-s10s {ECO:0000313|EMBL:ETW13937.1,
RC ECO:0000313|Proteomes:UP000019063};
RX PubMed=24567080; DOI=10.1007/s10482-014-0140-5;
RA Li G., Lai Q., Liu X., Sun F., Shao Z.;
RT "Roseivivax atlanticus sp. nov., isolated from surface seawater of the
RT Atlantic Ocean.";
RL Antonie Van Leeuwenhoek 105:863-869(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETW13937.1}.
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DR EMBL; AQQW01000002; ETW13937.1; -; Genomic_DNA.
DR RefSeq; WP_043842136.1; NZ_CP090152.1.
DR AlphaFoldDB; W4HMG3; -.
DR STRING; 1379903.ATO8_03566; -.
DR PATRIC; fig|1317118.6.peg.734; -.
DR eggNOG; COG0210; Bacteria.
DR Proteomes; UP000019063; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000019063}.
FT DOMAIN 29..309
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 310..584
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 792 AA; 88435 MW; 2C025C403BF78A38 CRC64;
MSSFDEMDAF EGASLASRAM QARPTPYLDD LNPAQREAVE TLDGPVLMLA GAGTGKTKAL
TARIVHLLNT GRARPNEILS VTFTNKAARE MKDRVGRMLG QTVEGMPWLG TFHAISVKLL
RRHAELVELK SNFTILDSDD QLRLMKQLIA ASNIDEKRWP ARQLANVIDG WKNRAITPDK
IPAAEAGAFN HEGPRLYAEY QARLRELNAV DFGDLLLHCV TIFQTHEDVL AQYQRWFRYI
LVDEYQDTNV AQYLWLRLLA AGHKNVCCVG DDDQSIYGWR GAEVGNILRF EKDFPGAHVV
RLEQNYRSTP HILAAASSVI EGNQGRLGKT LWTEADEGEK VRLIGHWDGD EEARWVGEEL
EAMQQGTRGM RPYSLDDCAI LVRASHQMRA FEDRFLTIGL PYRVIGGPRF YERMEIRDAM
AYFRLVVSPD DDLAFERVVN TPKRGLGDKA QQTIQRIARD RGVNLVEGAR IAVSEEAIRG
KGGAALRVLV DDLDRWGRLT GDPDLTHMEL AEQVLDESGY TAMWQNDKTP EAPGRLENLK
ELIKALEGFE NLSGFLEHVA LVMDNETEAE GAKVSIMTLH AAKGLEFPAV FLPGWEDGLF
PSQRSMDEQG VKGLEEERRL AYVGITRAEE VCTISFAGNR RVFGQWQSQL PSRFIDELDE
AHVEVLTPPG LYGGGYGAAG MAASASPEIM ARQQSDLHDR ASRADVYNSP GWRRLQSRSG
ERPVSQPRES KTQVIDMNAV AAYVIGERVF HQKFGYGAVA AIEGDKVEVD FEKAGTKKVV
SRFICAADDV PF
//
