ID W4J1E9_PLAFP Unreviewed; 2001 AA.
AC W4J1E9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=PFUGPA_01906 {ECO:0000313|EMBL:ETW56123.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW56123.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW56123.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW56123.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW56123.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW56123.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; KI927328; ETW56123.1; -; Genomic_DNA.
DR SMR; W4J1E9; -.
DR EnsemblProtists; ETW56123; ETW56123; PFUGPA_01906.
DR OMA; HCYDLLH; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.30; -; 1.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR012331; Clathrin_H-chain_linker.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF01394; Clathrin_propel; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 7.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 6.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290}; Membrane {ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT REGION 143..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1928..1955
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 148..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2001 AA; 233381 MW; 609833F1BA9BD175 CRC64;
MSQNNPLSVC VADNLINYDI QNESFRLGNV SVEGDKYICV KENVNENTQV VVINLHNKNS
TRKHMKAESV IIHPNDPILA LKGTIKNMNT IFLQVFNIET KEKICSLNLN EYMNYWKWIN
NDTIAIVCEK NVYHWNIDIH NTKKNKDNND NNNNNNNNNN NNNNNNNNYF NTLTKVFEKA
QIFIDNNSQI LYYSTDKDMK WCILCGISTQ DQGKSIDGYM QLYSCEKKLH QTIEGFIGCF
GSFVFDNLDM KPLFCFVEKK KNSTISRLHL MDIYTNKTET TIPYKIVKEI NLINENLNDF
PIYISLNTLQ GVIYIVTKCS YVYVFDEGTL SLIVKEKISE DNIFICCDSK NGEGIYAVNK
KGIIFYITIN YFHLINHLKL SNLEFKDKII KNLCVKYGYP GCDYISAYKK CINDMDFKKA
SKIICLMKNT KIFEEHSNNI AESILIMNRK NIDIRIIPPL RTQQVLNSFK SFKNTSGQLS
PLLLYFSVLL EYDKLNTYES IELVKPVVLQ KKKEYLEKWI KDDKLTCSEE LGDLVKVLDL
RLALNIYLRC SSHNKILSTY CLLNMFNNVL SYINNFKQIN FDYVGIFITI VNYEFPQGNA
DNKDSAFVGD FNSGSKNETM DFFNDGAASI SNDQNNSINK LNKGHINEVA IQYIKFLCEN
NISFDINKII DYLLSKKKLQ EATSILLDYL KENKAEHKNL QTKLFEFNLY NNVQVAETLF
QMDIFTYYDK NKIAYLCEEK GLYQRALENY TNINDIKRVI TKSTCFQKGG NNNNTTTTTT
TTTTSNMGDG HFDMNNVSKG KISIEWIKNY FSTLSDSVCE ELLFDFMKGS KINMEVVISI
CVQYYDKIGI KKIINKFEEN KNYEGIFYFV SNILNDLPNL IVKGNNNDNL SNNSLSTYNN
MNDEDASILL TSDICSTPQY SYETANLKLE DVHYIMFKYI EACVKINNIQ ELDRICKDKN
AKYNPEQIKN FLKDCKLSDP RPLIYVCDIH NYIEELAEYL YKNSLLKYIE VYVIKVNPNN
AHKVIGVLLD LDASEDFLLN LLNNIKNISN IGNLIEIAEK RNRLKLLLPW LESRANEGYE
NIELHNALAK IYIDLNKDPE NFLKNNNFYD KKMIGKYCED LDPHLAYTAY ERSNGECDEE
LIYITSKNGL FKLQARYLIS RQSIELWKVV LDETNKYRKN VIDQVIGSTL IESNNADEIT
VTVKAFIEKK LSSELIELLE KIVLHNSEFS DNKNLQNLLI LTAIKSDSKK VMEYINRLDN
FSGPQIAAVA YEYKLREEAF VIYKKFNCYT SAISVLLDKI LYNKNQKNKN FHEFSSHDST
VPYYSNNNNK DNIFGNKSDN ENDEYLKQFT QNNSYREKYG SYYNNNDISN SNNNNIHLHP
EFNNEDKFSS DTLHNYEDID STESTCDLSN YEDDLNRAIE FAQKCNNNDV WFILGKAQLK
LNKIIDSIDS FVKSNNPEAY KEVIEKCKEN NFYEHLITYL NTLREQNSLK DVLVDSELLY
AYAKLKKTNE MNKFINTTNS ANLQLIGDRL YKEEEYEVAK ILYSNIPNNQ KLTACYLKLK
EYALAIEAAK KAKSLKTWKE VNFICVKYKQ LKYAHTAGLQ LIMHADHLDE IIKIYEKKKY
INELMNLLEN GLNNERAHVG IYTELGILYA KYKPEKLMEF IRNYTNKMNT RKLIDVCENE
YLLKEAVYLY ISYDEYNLAV DTIIKHSPTA YTADTFMQVI HKVTNSDIIH KVIDFYIEEH
PLNLYNLLKI LENKIDNNRL VQTLKKSNNL PLIQKYLEDI QAQNITAVNE TLNEIYLQND
DYISLRNSID EYDNFNQTNL LNKLENHKLP EMRRIAALLY KKNKKYKEAI NLSKKEKQYK
DAIEIARVSK NNVYIEDLIN YFIESKNKEA FCACLIVCYD LLKPDYILEI VWTSGFKDQA
MLYFIQIISD YTNQIEHMKK QIEDMEKEKK MNKSAPNDYS AMNNQFNYSL NNNLSIMPPQ
NNFMSSNSFD KYDMFNNNTH F
//
