ID   W4PCK2_9BACE            Unreviewed;       449 AA.
AC   W4PCK2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN   ORFNames=JCM6292_3412 {ECO:0000313|EMBL:GAE16904.1};
OS   Bacteroides pyogenes JCM 6292.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1235809 {ECO:0000313|EMBL:GAE16904.1, ECO:0000313|Proteomes:UP000018861};
RN   [1] {ECO:0000313|EMBL:GAE16904.1, ECO:0000313|Proteomes:UP000018861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 6292 {ECO:0000313|EMBL:GAE16904.1,
RC   ECO:0000313|Proteomes:UP000018861};
RA   Sakamoto M., Oshima K., Suda W., Kitamura K., Iida T., Hattori M.,
RA   Ohkuma M.;
RT   "Draft Genome Sequences of Three Strains of Bacteroides pyogenes Isolated
RT   from a Cat and Swine.";
RL   Genome Announc. 2:e01242-13(2014).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC       sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAE16904.1}.
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DR   EMBL; BAIQ01000047; GAE16904.1; -; Genomic_DNA.
DR   AlphaFoldDB; W4PCK2; -.
DR   UniPathway; UPA00782; -.
DR   Proteomes; UP000018861; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR   NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR   PANTHER; PTHR43787:SF3; FEMO COFACTOR BIOSYNTHESIS PROTEIN NIFB; 1.
DR   PANTHER; PTHR43787; FEMO COFACTOR BIOSYNTHESIS PROTEIN NIFB-RELATED; 1.
DR   Pfam; PF13353; Fer4_12; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01072; dehydrogenase_like; 1.
DR   SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          94..320
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   449 AA;  52098 MW;  1EA34E598983CED0 CRC64;
     MEGRQIISKY THLFTVQNQG DTEYIVYNSR NNSFFKISEE LYIVLQEYSK DPQYYIGLIR
     NDCLSSLQKA KIIVSEDEDD NFVRQSILKS NLDSYASSHL SLSIAPTSGC NFRCPYCYEE
     NKPNVTMTDE TIKNMISFIN EHQSIKTMGI TWYGGEPLIA FDTIKKILNE IKHNSHVKLT
     SQAIVTNGYN FNQEVINFFK DQNLGKIQIT IDGPEEEHNK RRILQNGKGT FQKIISNLKV
     IVRELPDSHV QIRINIDKNN QDGFIILYKE LKELFNSHIA IYPGYIRINN KFQTGITCDS
     VDQNEARLFY DKLEKDGNIK VNYCPQIIRQ RGCVATCITG YVIGPSGEIY KCWNDMGYPE
     KIVGYVNQNK LTNPNLYNQY LIDGQWTADE ECKKCFFLPI CSAGCAWQRI RNKFHKGTYD
     YCSLYKGEGI DKYLELHYRK NYLLSNKKD
//