ID W4VRC8_9DIPT Unreviewed; 2830 AA.
AC W4VRC8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Putative toutatis {ECO:0000313|EMBL:JAB55848.1};
OS Corethrella appendiculata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Chaoboridae;
OC Corethrella.
OX NCBI_TaxID=1370023 {ECO:0000313|EMBL:JAB55848.1};
RN [1] {ECO:0000313|EMBL:JAB55848.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary glands {ECO:0000313|EMBL:JAB55848.1};
RA Ribeiro J.M.C., Chagas A.C., Pham V.M., Lounibos L.P., Calvo E.;
RT "An insight into the sialome of the frog biting fly, Corethrella
RT appendiculata.";
RL Insect Biochem. Mol. Biol. 44:23-32(2014).
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; GANO01004023; JAB55848.1; -; mRNA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd15545; PHD_BAZ2A_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF2; IP14655P-RELATED; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 2: Evidence at transcript level;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 747..821
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1048..1111
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 2347..2397
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2401..2453
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2738..2808
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1641..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1799..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2272..2303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2454..2479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2652..2709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1668..1698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1799..1818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2272..2296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2652..2666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2667..2709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2830 AA; 311496 MW; 05F81B5A116AF6B0 CRC64;
MDKDGDKKGN DKKGSSSSGL SGNAAADQAA LLDAASLFAY WGRDPTAMAA AAASNPLFGS
HFGAAGGLGL LPNAGGGSSN TNDRFSGLPQ HNTMAVAASQ AASLAGLHSA SWWSMAQLAA
QDYFARLQAS GMSQLPFPHP DLAGAFQGLP GLGALGAQAT GSGGSSSSSN SKNNLSNKSK
KRERSSNSGS STSSHQSNPG GSSSGNNNHS SLSYKNSASP SSLSTSQANA AAAYKQSLYS
SANLHKELLA ITAAAAASNN SNNSSSMKKS SNSSSSHHHS GSGGSSSQRL SSSGSHSLNS
SSSSSKSQQI SSPSITISAT NQSGSGNYQN SSSSRSKDSN SNKTSADLSI SASMNALNSL
TQFGNLDLSQ QNVTATMNAL AASSAKAKDY MSSGILNDPS SLLGVRLPPD TEIIKYTSSI
VGPKVPGTTN RGRKKTISLD PNPFFAQMHG LSAAKRARLE GEYSSSIPNA AHQNDRIEVI
KLPPTITSNG VYNIGKNSGK ESSDQASDWN AGGLNLSVKS STTSSSGATA SVGGSTTPIN
LTDGGNSDVD APLNLSLKSD TKGSSSSVGG NSSNSLQSLS SITAALGNNS STNSDQRSKH
KEGRHSKNRQ THTTSTSSSS TSTTSISSNH FASLGLNSSL SELLKISNYD EYDDYPSNSS
TQYKEGRPRN LGRGVSKPKK NTVASLLAQS RAVGSKPLTP QQMLSQEADL EKLRLAMIEA
SQSMDTSNTD TESIAESGLS ESEGEDQVNI KDLRAPVDKG WRRETIIRGL TKNGQIKGDV
FYYAPGSQNK LKNINQVLQH LEILKAAGLT KDNFSFSAKA IVGTFLQPAP LPYATDGEYI
KMTDVEVARR LEDLKMFTRH TTLNVEQRIE IARQQQALRE AKKMAKEEIS KNKDKAKHAK
EIERTERLEI QRRERELKNQ QALEAKRKRD EELAKQKAEE AQRKQQMYLQ DLNKQKELLY
TVELERERRR QHTTLIKQLD NRKRYEDREK KKNQLILDKL IQREKRLAIR KRDTEILAEL
RKPQEDSEIP EQIELPTFPR LPGLKLTGTA FADLMMVFEF LHNFGETLGF DMESLPSLQS
LHQALVCEDA VEAEEELLSV MTHLLVCAIE DPGIPNPTRH TTLLGQTLKQ ADITHTNVSE
ILRIYLHATA TGETRTLTGI NIEHYGRRSD PEQDQHTSAA NKQFYDALQE NIRWRISECL
KDKPFAALNA TVKSQVLAML CNDLLLNKAV CKQIDGSLES QAQLKKERYL LDSKIRKFKL
LVARKVRLEQ YEKAQALALE KSMSMKLSEA AEKDSLNNTN ETIAGGVTAT TPVIVAENMD
STNASVPPMS TPNSDESTPT SNTPTEGLTN HKDDSNIPNS INNSTVNDKT IEESPSKTPS
IAGDDKSKDL SFNDVSASEV SSAVNSTPAT PLDLNSLLSK NIVNEEKNDD ENSDLESEGT
NVDEDEDASL NAEEAQKKLD KILETSFQNK QQLENALHQL RGKCFGQDRF WRRYWHLAKS
GGVFVESMES TQSEIFKYNY VLEELHNNPT QPNFKHQIYD SIKRENVSTP LSVPNYMSVH
GSFGSEKRKR GRPRLVRKDT FESQDNNSES QDNDSRTSFT NDDGKNDSQS DDNIVKSGTP
VPSETSAIAS TVTESIADTV DDDKQQPEQG EDITTQLPPP PPPQVVQAAP TSQQQSQQSI
QTNSNSNNNN NNNNNKTAED DLMDIEDSIP TAILVQKSNN IDETKIVEVN NQIGGINVPP
QVYDSNVNND VNMLSASNNS NSNNSDISTM LNNDLIGTGG VGVAAPTNGN CDNLNNLTTN
ETNFNNSNNN GNGNSGGNDN KVDDEKADSD IEMIEIKDEP IVIKDEKTED EINEDVKMFM
EKWFSIVDKE IQLQTNECDT PTMKGTNGAA IAKTVYCNIT CRDPHQFQGN RWDISNNIHF
FNILLEKGCD VQFNNESVLT LSGLDENEIN EIINKSIKCE QIMLLQQQQQ QQMQQDGTDS
MDEDDKSNIE MDTKELIDTK VPLILDQQPE LTVSSDVKTE ENVDNSVVNP PSISSILATV
DIKDIKPVVK YENKIEEVNY FTLPSYMTLT LSNLTAFVQC DTFQPLQMTA EEQRQLEEVK
KNGYPKTLHR NFVPKDLRHG WWKISDIEHL NELIKSLNTR GVREKNLRQN LLQWLSESVN
LTTPHHVANP RAPPPQNGYI DPEPFNAWNP TISRRIDIAL LDQVEAMEDK IANASMQMKG
WIPPTRDSDN ESEFVTVEMI RERILGLEAA IERRYLKPPL GINTTEAQMA AIAQQEAHQN
SSSSSSTSSS SSSSSSRDKN KDIDEEIVPK GLVSWRDAVQ HSVTSAQLAM ALYVLESCVA
WDKSIMKANC QFCQSGESED KLLLCDGCDR GYHTYCFKPR MDKIPEGDWY CYECINKATG
DRKCIVCGGH KPPPFGKMVY CELCPRAYHQ DCYYPPMLKI PRGKWYCTNC ASKAPSKKRA
PRKPKEIKSH NSSLNSSTQD DAIASVAAGT AAVSTAPLSP VHSTIEQVSA LNNSKSQLQP
PIITPQIETT TKIDAKIIPS SSSTSLPSTL STNNNLSNKV QTDVEMLQQH QPLVNSDTAI
IDEQMDASSI IPTQPIIQNI EESFQHIIEP VSTAETIINP TIITTPPTVP MTSSNNDEES
NLVINENSFE HNTSTYNETS NDDSSLPNFN KDEEHPVKEK EKEEEKSEKV KEKKEKHKDK
DRDREKDEAK ELLKKEKKAT KKLMKELAVC KVMLEEMEVH EDAWPFLLPV NTKQFPTYKK
IIKFPMDLST IKKRLQDLVY KSREDFKQDV LQIFDNCEVF NEDDSPVGTA GHGMRKHFEQ
RWAELTDKHS
//
