ID W5IH64_SCAIO Unreviewed; 1579 AA.
AC W5IH64;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=CoA-substrate-specific enzyme activase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9020_01403 {ECO:0000313|EMBL:EFG26318.2};
OS Scardovia inopinata F0304.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Scardovia.
OX NCBI_TaxID=641146 {ECO:0000313|EMBL:EFG26318.2, ECO:0000313|Proteomes:UP000005777};
RN [1] {ECO:0000313|EMBL:EFG26318.2, ECO:0000313|Proteomes:UP000005777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0304 {ECO:0000313|EMBL:EFG26318.2,
RC ECO:0000313|Proteomes:UP000005777};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA Izard J., Baranova O.V., Blanton J.M., Tanner A.C., Dewhirst F., Haas B.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Scardovia inopinata F0304.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG26318.2}.
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DR EMBL; ADCX01000013; EFG26318.2; -; Genomic_DNA.
DR RefSeq; WP_040591344.1; NZ_GG770226.1.
DR eggNOG; COG1924; Bacteria.
DR eggNOG; COG3580; Bacteria.
DR eggNOG; COG3581; Bacteria.
DR HOGENOM; CLU_002393_1_0_11; -.
DR Proteomes; UP000005777; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 4.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018709; CoA_activase_DUF2229.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 2.
DR Pfam; PF09989; DUF2229; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Reference proteome {ECO:0000313|Proteomes:UP000005777}.
FT DOMAIN 6..279
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 364..618
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 714..932
FT /note="DUF2229"
FT /evidence="ECO:0000259|Pfam:PF09989"
SQ SEQUENCE 1579 AA; 173967 MW; 4D039F4494D7B4B2 CRC64;
MTSIRVGLDV GSTTVKAVVL DTDYGIDQSG NHIHQPFNQE DRSVLFADYR RHHANVRVAV
QELLIDIESA LKALGRQNEP VQLAITGSGG LTLAENMQVP FIQEVISETD AIEDAYPQAD
VIIELGGEDA KITYLKPTPE QRMNGSCAGG TGAFIDQTAT LLNTDAPGLN ALAKDHTTIY
PIASRCGVFA KSDLQPLIND GAAKSDLAAS IFAAVATQTI AGLANGRPVR GNVVFLGGPL
YFMSELRSAF TTMLDGQVDE FITPASAHLY VAYGAALAAN NPDAADITAK QKKEQEESGV
NIFRPRTCAD LITVIDSLKN LPSGNHTLRP LFLTEEEKKE FDSRHSRQQV TIGSLEGAQG
PHFLGIDAGS TTIKATLIND DQEIVWSSYG NNEGSPLLAA ARIVKNVETL LPKNAYIARS
CTTGYGEGLI KAGLHCDEGV VETMAHYRGA ELVSPGVTSV IDIGGQDMKY LSIDQGVIES
ISVNEACSAG CGSFLQTFAQ SMNLSIEEFT QAALRSQAPV DLGSRCTVFM NSSVKQAQKE
GASIEDIAAG LCYSVVRNAL YKVIKLRDTA DLGQTIVVQG GTFLNDAVLR AFELLTGRQV
RRPNIAGLMG AYGCALTARM HYEDGDRTRI LSGSQLDNLS MTTQRDVCNL CQNKCKLTIT
TFQDGSRYVT GNRCERGGDK NKKRSPLPNM YDYKYKRVFS YRRLTDKKAT RGAIGIPRVL
NMYENYPFWF TLLTNLGFKV ELSRRSSHNL FEKGIDSIAS ENICYPAKLV HGHIKDLLSK
GLTTIFYPCV FYEENLAPDQ DNKYNCPIVA NYPGVIGANM EELRDPKIRY MHPYFNLSNH
EKMVDRIVEE FSWVHVSRQE AQQAVSAAYA EDKIFKHDVH MEGLRALTYM KEHKLRGIVL
AGRPYHVDPE INHGIPEAIC TMGMVVLTED SVSWLQPGRK LNLTPFIGQE EANPRLHTRD
GFRKVDDGYD PYNLSGASLI SDGQAALGLG RVLQAQSVGS ARTRNGQTAL KADYDDPTRE
ATDTTANAYA DHQKDRKALR VLNQWAYHAR LYAAARFVSQ YPTLELVQLN SFGCGLDAIT
TDQVQEILGE REDVYTVLKI DEVSNLGAAR IRLRSLKAAV EERVKRGQGD AAGKTEVSDG
GFRHTSRTGV SMSKYSHITP FTKDMKKTHT ILLPQMSPAH FGLLESVFRS GGYKADLLEH
VSRSDIEFGL KYVNNDACYP SILVVGQLVN AIADGRYDPD HVALGITQTG GMCRATNYYS
LIRKALADAG YPQVPVIALS TQGFVSNPGF SITPALAHRA VKAICLGDLL MKVLYRTRPY
EQVPGSADQL YERWETICRE TIEHHGFSVT AKKYYHQPYL TFGRLCKSLV RSFDQLPLRQ
IPRKPRVGVV GEILVKYHPD ANNNVVKVIE SQDCEAVVPG MMEFMTQSLY SYKWNQKMLG
TQYPPAVKET ARIICEKYRK QVEDALALAD GKFSQDTPIP QLMKKASQVT SLGVQAGEGW
LLTAEIVDLI EHGAPNVICA QPFACLPNHV TGRGMFHEIR RQHPEANIVS IDYDPGSSEA
NQLNRIKLMI SAAKKAVRR
//
