ID W5J275_ANODA Unreviewed; 2993 AA.
AC W5J275;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Focal adhesion kinase 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AND_010587 {ECO:0000313|EMBL:ETN57836.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN57836.1};
RN [1] {ECO:0000313|EMBL:ETN57836.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN57836.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN57836.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC010587-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; ADMH02002203; ETN57836.1; -; Genomic_DNA.
DR STRING; 43151.W5J275; -.
DR EnsemblMetazoa; ADAC010587-RA; ADAC010587-PA; ADAC010587.
DR VEuPathDB; VectorBase:ADAC010587; -.
DR VEuPathDB; VectorBase:ADAR2_006922; -.
DR eggNOG; KOG4257; Eukaryota.
DR HOGENOM; CLU_226121_0_0_1; -.
DR OMA; DYELDRT; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR GO; GO:0007172; P:signal complex assembly; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13190; FERM_C_FAK1; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR041390; FADK_N.
DR InterPro; IPR049385; FAK1-like_FERM_C.
DR InterPro; IPR041784; FAK1/PYK2_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR036137; Focal_adhe_kin_target_dom_sf.
DR InterPro; IPR005189; Focal_adhesion_kin_target_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46221:SF11; NON-SPECIFIC PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF21477; FERM_C_FAK1; 2.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18038; FERM_N_2; 1.
DR Pfam; PF03623; Focal_AT; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF68993; FAT domain of focal adhesion kinase; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 874..1280
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1393..1684
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 24..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1845..1886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2101..2121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2189..2220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2326..2388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2460..2484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2528..2637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1845..1877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2206..2220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2349..2365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2373..2388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2468..2484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2549..2596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2993 AA; 324902 MW; 68362D94403F59BD CRC64;
MSRNIIDTSG IVFSNRMAEL HQGPAQAPPR LLRPSQSSKV YPIVSSSSSS SSPPVVTGTK
LLPDDVRCLH ADVEGVVVMR NRVIDLDKNR IKCRNRNRIW PRPSSFLSFF KQSLSGSSSS
STSGGGGSSS ILTNGSDNEL QRPSTPRNGD ASKVSKVSSK GSVPPPPTPA KPRGGEQQKC
RGAGPKLLDL DMIRKLEEEI YKRGREQQPD HAEAKDFHEF YFNNNNHGGN NNNNRRKTFT
STDTTAFNGD SHRAVLLVDS EALEPLLMQR PLTTEEEQQQ QQQQHHEEQR EQQNVPQLVD
GGHAGGKKSI IIVDNSEYYP VLMRYDINAE QIDRHQQQQQ QFRRRRSEKL KIDTGTAAGA
ATPPAASKAS PPGVVTAAGD TLVVSPTSSP IVWEFPGSRA AETSSVNAAP EEENGADRGA
KKQPSSGNRS TNLFQRFLQQ RRSLNLSMRR KRVVGRPPQH ECSHFAPGYP HPGLLAPAVS
TDYPFRRPPP PPAPGDGGGV LLRQCTGSTG SLGSSRTSAS NKVKFEYLKR MARYDCEPRS
GNRRTNSING SSGERIPERR RRWIRRAVSE PDLVSRQNWK SDSFVQHLQR YRRTLYWSTG
DLSSLGRMVA SGKNFENIFD STSDNLSARL SAVVMSGGSS VTGSLSSSST STTTGSSSMA
SSSTSGSYQQ RLLQRRIAAA MLKHHQSVGN IKPPLASSSS SSATGGNILR KKSSSFRGVL
RRSNTPDVVN TWVYRKSSSS SALAFYAYDG SGNNGLGEPP YHGRGHGSPH ASPSRYSYNN
SNNSNNNNST AKSPLQHWRT SSAGASDFKR NSRLRSSANA VITGSGGHHQ QHPQQLNHHH
HHHSNSNMGD LNVPRGYSPN FSPSRQTTQT GDTQTLHVHL PNQGFRMIRF DEASDVRQII
NLIVGWMSPG HKPNPQSYAL RLRHMLTKEV LWMPPDTSMS QVMAHIYNPS CSNADCPNVD
KSTIAKRMQQ KTSGAVGHAN SVWKAELRVR YIPKSLRELY EKDRTTCHFY FDQVKQDYIQ
SNVPHIDPDT AVQLCCLGIR HYYKDTNHTS SDRKQHLDYI EKEMGFGNFI PKSVIDTIKQ
KNLKKQIQAG YKKVYGYTEM EYMLKFFDIL RTQYTFDQEQ FNVQLSSGWN IRVDLIIGPH
VGLSYSTNPQ APPIKVTDFE SIERITTSVL ATSLTKSDHQ PSAAASSAAA AAAGRSLKDQ
QPDLTSSCGG ASTSSSSSES KKDAKSRGAA QCSCAEIKTQ LRIRVAGNSE DLAITCDGIK
TSESIADLVD GYCRLFNNND VSLWDRTAVI PKGATPTGSA TNSLEKSREL KRSLTESQTS
ESNTRSSNDR LNGGGGGGGE SDAATGGGAG QGVASQPPKP TLNEDYAELG MCDEEGDYST
PAARDYELDR TQITLNEIIG VGQFGDVHIG TCRLPTKSTL VSKLNQSLTS EFDEYSQLIL
DNGNAEAQKT GIIQVAVKTC KSDADTTTSE KFLQEAYIMK KFEHPHIIKL IGISSGPPIW
IVMELARHGE LRAYLKKNGP KLKLGTLLLY SYQLSTALSY LESKKFVHRD IAARNVLVSS
PTCIKLADFG LSRWVEDQSY YTSTKGMLPI KWMAPESINF RRFTTASDVW MFGVCTWEIL
MLGVKPFQGV KNCDVIGKLE NGERLPLPAN CPPRLYSLMS QCWSLEPHKR PNFKSVKETL
YEILMEERHS DCETMRRENR RVAAMSWGAG DDMAPPKPAR GPTMGADGPT MPAGAPITYI
VARDPTVLAA LMRENEQRGV NPSSYTTPAS VFNTLAVDLD PNAPPSNTDN QAAKELAVAN
LPLKTAPLPV TELHKLDPTI EESTAGAEGA EAGASALAPT GALSQATFEE SSQNPYGSGR
VAGSGLLTTT TEDGEPDATP TDTLERYKNP HDVLVLSANN NLVSMSQSSS FVTAPGSQML
SSVSSSPSMN PSVIVASQQA LHHAVASHHP HHHAPAPGGS VGYPVPCEII NALTQQTHSI
EPTYKAIQAK PSSQPANLNP QLMNNNFMHS NAQQGQQQPH QTQQPYYPQG NSIVTYQQYH
TQQQQQALAA EQYYHQQQQQ QQQQQQQYVL HQQQQQSAVP YSPYGTTQGV SQYSPASYIK
SPQQEEGGQQ PGGAKSRSLE RNCGGQNIVS AYAARINSLE RTRQMSMEYG SGGGGGGAKA
MRSNSLTRQY SGGNQSDLYP GIGHGVRSAS LERGAPGPPG SYMSRMGSLE RNQQQQQQQH
QSIFLNSIKG GSLERNQSAA IVSDMMSGKI GGYKGGSLER NQHILMSRGG GSLERNMPFQ
NYRSPVAAAP KEQEPFQEEI YDFGGVNVKS CASIALKKSV EKGMLPPSSL AVSPGPPTAG
ANFALPPPYS SAAKQQQQQQ GTPQRAHWGA PGLLHQQQSQ QQQQQMYIQQ SQPLPMNTSG
NMMMSQAGAG PIIGIASSQQ VQIPMKISHG QSIAQQATQP VLPHGGVQIA TAVAQPIVAP
QPMGHPTPMA TDNVQQSQQP AQIQETQQIL EEKLRKQQQE SEIDSKWLQQ EESNLKKRLS
LITTATGNMS LEQQTPSVAI PQDGGTPPIN GGGSLSGSYH SQQSPHFSPQ NTMSGPQSLG
DHYPTTPNTT DSRPHTPGSG GGGGGGMIKS KSSSMERCTT PQSGDEKFAV KKVEPTKTMP
LDRTNDMVYN ATTSVVKSIM ALSQGVDRAQ APEYLNLVRN VGIELRTLLG AVDQLSTNFP
AQCHKEVEMA HKVLSKDMHE LVTAMRLAQQ YSETTLDAEY RKSMLAAAHV LAMDAKNLLD
VVDSIRVRYP TLFQRQSSVP GSPTQRQQHA AATAATTTTT TVSNIIHPSN VSLAFSQQQQ
HSFEHSSSLM GGVGGECYQN LQPKQPMLAH SSPPTSLTHS YETTTAAATA TGVPPAAGIA
YGMQQSGIYD NECIINSQQQ SSEVAKLKKP AIAAKPPCVV TLASVKLKPV IAGGSSLDGS
EGGGGNGSEL YSNTGATGSV DIKLPDPVSC TIVQENLLAA NNQKVMATNK LSG
//