ID W5J4I1_ANODA Unreviewed; 2647 AA.
AC W5J4I1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=AND_010685 {ECO:0000313|EMBL:ETN57724.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN57724.1};
RN [1] {ECO:0000313|EMBL:ETN57724.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN57724.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN57724.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC010685-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02002218; ETN57724.1; -; Genomic_DNA.
DR STRING; 43151.W5J4I1; -.
DR EnsemblMetazoa; ADAC010685-RA; ADAC010685-PA; ADAC010685.
DR VEuPathDB; VectorBase:ADAC010685; -.
DR VEuPathDB; VectorBase:ADAR2_004098; -.
DR VEuPathDB; VectorBase:ADAR2_004576; -.
DR eggNOG; KOG3522; Eukaryota.
DR HOGENOM; CLU_227617_0_0_1; -.
DR OMA; DEGMMIC; -.
DR OrthoDB; 2917131at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 2349..2537
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 67..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1432..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1668..1693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1787..1817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1987..2246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..430
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1249
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1561
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1872..1890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2059..2085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2096..2132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2142..2156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2172..2187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2226..2246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2647 AA; 281991 MW; BA4C1A0091871AD3 CRC64;
MTSKPEPADK LGRNMKALPA NCQKLADGIQ QSWNRAIPEN DYIQLGTLRY GVRLSNTGLL
EDAMATDRGG KAASDHQHHH HRSSSRGSSN GASYDHFSNG SDGGGGSRAG SIPCSTGSGS
SEQPAANCCC IRASSNDPSS NVEIPPWTNS YGTRTKLPVP ATGNGAGSLN AKNRKSSPSA
STASTVAGGW GGLASPATSP AHHQHQYQQQ QQQQSRHLHL APNRTTNGHA LSSPSTQSYG
HGSEDGPSLG YSNGHTNNNT NNGGQLHHHH NNNNNNKNNN GYHNNRNGAE ANEEPDQQQQ
QQETSQTGES TSPRCSAVVC CYGNSFGTGT ITGSGRKKRP TNNKEHEPQT VSPGAPHQHH
PRDIQRLREH RDAGVTVTGG GADRRALHRG SDRGGTTQLV RGNASVCVQD DDEDADVDGD
DADDDDDDVA DDDVSALVAA SQQLLYANGF TADATIGGTD AGGTYEDDGG RSSGSFYRFA
DGDLNLNPRN APQQQQHQQQ QQQVLQRWQS APSANAGVTA AVVTDRRELN INNFEKKQVA
STEPHYGQSF VASGSGRHAV EPNRSASPNG SSPAGPDWSV VGGRGRTLQP PSSLPVKSYS
FHRDRDRTAG GGAAGQLFDR CSPLFEPLPL TTGRNRSFRN AQHTPVVRRS SATVRHGTVP
DEPRSPGTDF GTASGLAFSR TVRQSPPGCG AESEYPSSPV PTAPTSPYGR VNTLLTRKSS
LPVLSSERNS SYYHQQHHQQ QHQQQQQYPV ISSSRASIDE CYPFDKSTCQ PECILTPRSH
RKQPCSDALN EIRLQSLNKY CNQLLLAGQQ QQQQQQQQQP FVASPRPGRR GPSTSRRRPH
LDELEDELGF IDSSDLSSAG DEQSGGHNGL IAITSKHPRR PTSHQQQPQQ HQQQQQHSSI
ITHGTVRIAA AIVVTGGTLP AVAAAAASAG DGDVTGASQH QHYGRNIYND SSSDELSSVC
SGVEQLTRAC ASVVVGSPIA ANTTNSSGVG GGAPPSANGH QPYNAGNASN GSLLRSFGRR
TSGTLGSEQN NSTSDSNNNN NNKRRHRFAD DDVGNDGDGV GDVGGTKHTN TAATVATPAT
AAAAANNSSA TVVNGTVGVS VSVATDVTGV SGGSSSRHQQ QSQQQHQPPH VGLNCFGRST
SLHAAPAAAA AGASTGDKSI MEKRSNTLDR LQRFVKKSTS SANAEKQQAS GGGGGGGQSG
NGGSSTASTK TERLRELTEL LTKGGSRGSS VPPAPPPPPP PPPIPPPRRA KQSHSIDRGS
GTPMKATTST TSLIDSILSQ STGGEMSPMA AKNKVSRSVD LPYRFADSGQ RMSTPSSPQP
EHKPQLSLLR ANVSTSNLEV ALHDGTTARP LAKGGQPSSP GRGADSETTL KMADDEDQQL
FVKLSRPESR TIVGSYTQKT IPFRSASFSQ VDYSSGKYIR SALGALKNSL LSSKGGSSKD
SATVTGDETG AGKLESTARS CSPTELCGGP TTTARYAEDT DVAKLTIKKT ELSINLMPMA
DDFGRLVCDD RLKRFEGKDL ASNRNSDIET IVEDPVAEHV ENVENPAPAP SPPPPPPPGD
EEGSTTVMVN PAASINVMQA SEMVLVEPPV EEGIPITPCS LSKDDECLQQ ATTCLIPVPV
YDCVVSEWST AKPSEQWIDA SMTEYSKFQD CLGSIKEVNE SAIAEVLPAM PPPSMPESSS
SIEEEEVEDE DAELPVEKIT IARPPQIIEP LDTTIDLSEA DVGALFCTPP VSIICTEPES
NEFTTIIDGA GGVGGGTTPS GVVSGTQHKV SVVLDDGSEV VEVVEVRKRH SNNEDAGGDT
PSSRHSNELD EKRRLESRKS RRKGIYIQWP AIDGNGSELE PDGTTAGAGA GDGSVLVASP
SSVTGSSCED RHAGNWTHKV RNEKDSSLEL SGESFTDLSG REDGVSGKDG MERPGTYSPD
ARYRLDPTTP DSDTGRNAPV WPVKGDAAAN HHRRQSLTYQ SSDEKDDTLA LAPAATGGVR
SLKSTFLRSD SVSDCESDRA SSRDRTSASP APGAGTDADL KRYSKRPLRG PYGQMLEAEM
KKPTAKVQYN EILEELTRNE SHGSLTSVST TRSRGGAGSQ SMDETNDRHT GGKSSGKPRK
TSANLPVPTH VRTASSPSKL SDSSSHSTGG GGGGGSAASR RHLSHIEQRS TDSDRSEKSG
SGGGGHGLGG KKFSLDSHHH AASEKVSKRA SEGSGGMVVH EKHHGAGNKR SCSSASDKQP
KRSLDEVVRL SQNSRTPSER SIGTLQTPEM LGTSKGMAAS PELLAELLKG SSEKLITEQL
TTTVTGTTAT GSPGPNAGNA LPSAVLNCLD PAMMPLNFCS DSEDDPERTP KSVSETTMWH
NVISCYNDTR THVVVELFNT EKSYVESLQT IVLKYLNQLK SPDNAGLVGV QTVDEIFFMV
PAILNIHERF LEELRRRLDS WDKLQMIGDA FVDVFSRPVI LDTYTAFVNN WNRAKDAIRS
AREKCPAFAR FLEAMAREHK GKLSLDNLLI KPVQKFPNYE LIFTRLIKHT DVAHPDQKPL
QEALKLVHDI LMFLNCKEKE ALENGQRETA LRELEGVIEG MNDLVTPDRA FLLFDLVSMP
SGQVTRKERG FFLFNDLLVI TSIKRRSGTI RKTNMTCPGS VASTLDTNKY KYLTKIALDD
LEIVKCK
//
