ID W5J7Q2_ANODA Unreviewed; 906 AA.
AC W5J7Q2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN ORFNames=AND_009520 {ECO:0000313|EMBL:ETN58895.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN58895.1};
RN [1] {ECO:0000313|EMBL:ETN58895.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN58895.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN58895.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC009520-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02002111; ETN58895.1; -; Genomic_DNA.
DR AlphaFoldDB; W5J7Q2; -.
DR STRING; 43151.W5J7Q2; -.
DR EnsemblMetazoa; ADAC009520-RA; ADAC009520-PA; ADAC009520.
DR VEuPathDB; VectorBase:ADAC009520; -.
DR VEuPathDB; VectorBase:ADAR2_008760; -.
DR VEuPathDB; VectorBase:ADAR2_010562; -.
DR eggNOG; KOG1366; Eukaryota.
DR HOGENOM; CLU_320349_0_0_1; -.
DR OMA; DQEATAY; -.
DR OrthoDB; 3418615at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..906
FT /note="Alpha-2-macroglobulin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010154996"
FT DOMAIN 358..446
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 906 AA; 101688 MW; 2532644FCC322874 CRC64;
MDHLRHAKMW YRLVLLLLSV AWGFPAVSHG QSYVVVSLDT LRAHTTYGVV VANIAPKTQH
FRFEIVANNQ SIARTSAVDI AANGLKQIDL NINQLDPDAL HMLQVWDASK GVLLNATSVA
CSARSYVVLF QTDKPVYKAG DKILFRVVFM TLDLMPVQEA GITIFLTDPL GSRLKQWSSA
PLQNGVFEGK FQLAPEPSFG RWTINANINE QTYRETVQVE EYSVPLFNTG LKIIVRFQLQ
AQHTLNISAT RVDDTPQKYS ISIGAGNDAY VGLFGVEERT RIMSSGENDL SWKKLHRALQ
PFNEQHADEF LHDSFKRVGA LLLTDGYEPD VGPVLNAQGR VGSIFAEDEA PREHYPETWI
WESVRTLDQR IQTIERTLPN IGTYYLMAFA LDSTYGLQIT KPARLIFSKD IFAQLHIPPS
LNRSDEAIGH CLIHNYGASV TVFVEVQPNL VNTKLVLGAG ETESIPLKLL FEQVGDVKII
VTLRISNGSI IDTVQQKISV RQRGIVQFVE DVRLIHFPKM SQTELNLSVE LPKQNIIPDS
GKLTLSVIGS FPNLHEYDLL PMAGSSHMNG STNVLFFQTA LTIYEYLRNS GLLKADSLAK
FSPLVEVALQ NQLKFRMKSG AFSFLGYDVY DRCGSVWLTA KTVDSFIKAT EFVHINDRNI
EASLNWLQEQ MLPNGSFKEA CSSELDRAQI NGEYELSLAT TVLTSFINNK YSSKYSNLLN
RTLTMLLKAP MDDVYIIARI AHLLTLMKHP SRFTVIEQLN KQVIDVDGAF RYWLERKHPN
DEPSQRDTET TAYALLANIN EGTMASENIK RVAQWLYKRC FSANRFIVTA ENLIGLQALG
EVAKRIVVSE TNISITLPSM QNIVVNEINR DLLQTLPLTR ATPRAMVSVT GLGSAWVKLS
YKYNVA
//
