ID W5JLA7_ANODA Unreviewed; 786 AA.
AC W5JLA7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Zinc transporter foi {ECO:0008006|Google:ProtNLM};
GN ORFNames=AND_003353 {ECO:0000313|EMBL:ETN64891.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN64891.1};
RN [1] {ECO:0000313|EMBL:ETN64891.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN64891.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN64891.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC003353-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADMH02000839; ETN64891.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JLA7; -.
DR STRING; 43151.W5JLA7; -.
DR EnsemblMetazoa; ADAC003353-RA; ADAC003353-PA; ADAC003353.
DR VEuPathDB; VectorBase:ADAC003353; -.
DR VEuPathDB; VectorBase:ADAR2_008523; -.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_13_1_1; -.
DR OMA; PCSAHTN; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF37; ZINC TRANSPORTER FOI; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..786
FT /note="Zinc transporter foi"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010155608"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 80..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 87895 MW; BDD5273C7AB86C1D CRC64;
MARHIMAVCV VCLLCADHVR CKQHFSGVDQ ASSVERIKYD RTINPAIDHE QRWLPYGEYD
TSLHQRQEET NGDHRIVKRH SHHNHAAEEK KHGDEEDQRE EFERKLNPMV KEFVMKIFAE
FGNPETMQMD GKGFERMIDR LGLYQMIGGE VGAKITTSSV SATDSDRQQK DPNKCLSSAE
FLKRVTTVKV PSEEWHKEEY TASKDSEADN ATQQHNSSDH SIQSNTSVNN ESNSNTNSSN
NDHPIDDHHH HHEEESSENT ANNASQQTNG GISRFDSRDL YNICPLILSR LLAEDPLARA
GCFTPDSVPE LQTSSSHHIH HHDSEHSHEL AVWVYSFLAI LGVSLCGLLG VVVIPCMDKH
FYHHALQFLV ALAVGTLCGD ALLHLLPHAM FPDGLSLENA HDQMMYKGLA SVFGIVFFYF
MERLLTMIAE WYKGREKKDK PSSRVRVMRD PESNSLHLAA GSGEKQCKHK YSAYPYCYDE
IAMDTKDDHH EHNQVNENHN NVLAKCANSH GDEQQQQQQH QGNEHIPLNH NNSTSSVANN
HRHGGTSHDE TIHTTSNSID NNTVSSNLDD GSIESGEPQT VIPLKTEATK KLRKENYTII
LREHETKHHG HSHTHGHVHS PPGSLSAVVW MVIMGDGLHN FTDGMTIGAA FANNIAGGFS
TAIAVFCHEL PHELGDFAVL LKAGMSAREA VFYNLLSSVL SIFGMILGIM VGHQPQASAW
IFALAAGMFL YIAMVDMIPE LTSSHGAEER CKLSDFGLQL LGLVVGFGIM LLIAIYEHDL
MEIFVH
//
