ID W5JR01_ANODA Unreviewed; 1369 AA.
AC W5JR01;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Toll {ECO:0000313|EMBL:ETN65330.1};
GN ORFNames=AND_002906 {ECO:0000313|EMBL:ETN65330.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN65330.1};
RN [1] {ECO:0000313|EMBL:ETN65330.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN65330.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN65330.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC002906-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; ADMH02000685; ETN65330.1; -; Genomic_DNA.
DR STRING; 43151.W5JR01; -.
DR EnsemblMetazoa; ADAC002906-RA; ADAC002906-PA; ADAC002906.
DR VEuPathDB; VectorBase:ADAC002906; -.
DR VEuPathDB; VectorBase:ADAR2_004842; -.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_004280_0_0_1; -.
DR OMA; HNSIDES; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF22; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 22.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 9.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1043..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1098..1236
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1290..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1369 AA; 152778 MW; BA26588140A01C13 CRC64;
MEWLLRVMLV VMVVLVATVV TRVTVVEARS SFLNRMEMAP RGCKWQRVLD EMAAGGDEEG
TGGPATVTTV LSCKLKTIGG TDTLMRNLTA GQIERINALK LECSDILFFE SSLEANQHSG
AFLGSLKRLR DLKIEYCKIK YVPSMVLSTL RDLRSLSLRT HNTDWSAMNL EFHPESFRGL
TELKRLDLAD NNIWALPTDV FCPLFSLRHL NLTRNRLTDI SQLGFSDWGN GPTAPGKACN
TGLEVLDLSH NDLLSLPDNG LSSLRSLSVL MLQDNLLTAL ADRSFVGLGS LRVLNMSSNK
LVALPPETFQ SPRELRQIYL QNNSLSVLAP GLLEGLDRLE ILDLSRNELT SEWINRDTFA
GLKRLVVLEI SHNALTKIDR HVFRELYSLQ ILNLEANRIE SIADNAFSDL KNLVALTLSH
NRLKRIEQHH FSELYVLNQL YIESNLIESM HGRALENLTN LNDLNLNDNR LTEIPEGLGK
LRFLKSLDLG KNHINTVNNA SFEGLEQLLG LRLVENRITN ISRDAFVTLS SLHVLNLASN
QIRHIDQSAF SGNPTIRAIR LDNNELEDIS GVFTSLPALV FLNVSDNQIR LFDYSHFPVS
LEWLDMHQNN ITELGNYYDL NNLQIKMLDV SFNRLTEVDA KSVPDSIETL FLNNNLLESV
AAGTFLSKRN LEKVVLYGNY IRKLEIGALA LTRVAEDREV PLFYLGDNPI HCDCTMEWLQ
GINKLAHLRQ HPRVMDLDTV MCTMEHDRGA SIRPLMELNA QDFLCRYETH CFATCHCCDF
DACDCKMTCP DRCSCYHDHT WKTNIVDCGA ADYTEVPEHI PMDASTIYLD GNELQQLGSH
QFIGKKKLEV LYLNGSNIRN VHNRTFSGIP SLRVLHLESN YIPELRGFEF DQLTNLNELY
LDRNAIGFVG GQTFQNLRFL EVVNLSGNRI SEFRPWVAFA AARETGSLRR VSLEGNRWRC
DCESLGRLQR WIREVSGEYD LNRMVCADNR IVADALGSCS ENRLDFGGAL GGPGVDLSGD
GEEAPPTVHR TVLMGHGLIG GGYVPLLAAV VVAIIGTALI VALACVFRQD VRLWAHARYG
VRLVKDPIIV ASKEDTDRLY DSYVVYSVHD NEFVGRLLGA ELQLYGYSVC LHHRDVHPGA
FLADSLQSAA DAARKVILVV SMNFLQNEWS QPQFRVALQS VIENVRPAHR RHKIVIVLTA
PIELVSLDPI MNLLIRTCTV ACWGERKFWD KLRYALPDVS KDRTPKKLGD ITRSPNLRYT
PAPTSLDQWC KLGGAGGAVL VGSGADGGLV GAPMGGGPPP GGPVAVPQST PSQSTCNTED
ESSSASSQQY EAPMSQHYNG SRSSASLGHV YSTIPETPQM GRNGRAYFV
//
